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Protein Ontology report - lefty 2
PR:000000288 - http://purl.obolibrary.org/obo/PR_000000288
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000288   
  PRO namelefty 2 
  Synonyms
PRO-Short-label: EXACT:LEFTY2
Gene-based: RELATED:EBAF | LEFTA | LEFTYA | PSEC0024 | TGFB4
Other: EXACT:endometrial bleeding-associated factor | left-right determination factor A | protein lefty-2 | protein lefty-A
RELATED:left-right determination factor B | Leftb | protein lefty-B | TGF-beta-4 | transforming growth factor beta-4
  Definition"A lefty protein that is a translation product of the human LEFTY2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000102 lefty protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 1                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000288

lefty 2

LEFTY2


"A lefty protein that is a translation product of the human LEFTY2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O00292

left-right determination factor 2 (human)

hLEFTY2


"A lefty 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00292]


organism-sequence



PR:000000452

lefty 2 sequence variant S342N (human)

hLEFTY2/var:S342N


"A left-right determination factor 2 (human) that has an Asn residue at the position equivalent to Ser-342 of the amino acid sequence represented by UniProtKB:O00292-1. Example: UniProtKB:O00292-1, Ser-342, CHEBI:50347." [PMID:10053005, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:O00292-1

left-right determination factor 2 isoform 1 (human)

hLEFTY2/iso:1


"A lefty 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036549

lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]

Yes

organism-modification



PR:000036550

lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

organism-sequence



PR:O00292-2

left-right determination factor 2 isoform h2 (human)

hLEFTY2/iso:h2


"A left-right determination factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00292-2." [PRO:DNx, UniProtKB:O00292]


organism-modification



PR:000048185

left-right determination factor 2, signal peptide removed form (human)

hLEFTY2/SigPep-


"A left-right determination factor 2 (human) that has had the signal peptide removed. UniProtKB:O00292, 22-366." [PRO:DNx, Reactome:R-HSA-114708]


organism-modification



PR:000083292

left-right determination factor 2 phosphorylated 1 (human)

hLEFTY2/Phos:1


"A left-right determination factor 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-213 of the amino acid sequence represented by UniProtKB:O00292-1. Example: UniProtKB:O00292-1, Ser-213, MOD:00046." [IEDB_epitope:2149881, PRO:DNx]


sequence



PR:000000451

lefty 2 isoform 1

LEFTY2/iso:1


"A lefty 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00292-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O00292-1

left-right determination factor 2 isoform 1 (human)

hLEFTY2/iso:1


"A lefty 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036549

lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]

Yes

organism-modification



PR:000036550

lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

organism-sequence



PR:P57785-1

left-right determination factor 2 isoform 1 (mouse)

mLEFTY2/iso:1


"A lefty 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000645

lefty 2 isoform 1 cleaved 1

LEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036549

lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]

Yes

modification



PR:000000646

lefty 2 isoform 1 cleaved 2

LEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036550

lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

modification



PR:000025432

lefty 2 proteolytic cleavage product

LEFTY2/ClvPrd


"A lefty 2 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000645

lefty 2 isoform 1 cleaved 1

LEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036549

lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]

Yes

modification



PR:000000646

lefty 2 isoform 1 cleaved 2

LEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036550

lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000452 hLEFTY2/var:S342N
Example: UniProtKB:O00292-1, Ser-342, CHEBI:50347
associated_with_disease_progressionDO:0050545 visceral heterotaxy PMID:10053005
PR:000036549 hLEFTY2/iso:1/Clv:1
UniProtKB:O00292-1, 77-366
acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:10053005
GO:0007309 oocyte axis specification PMID:10053005
located_inGO:0005615 extracellular space PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2
UniProtKB:O00292-1, 135-366
acts_upstream_of_or_withinGO:0043406 positive regulation of MAP kinase activity PMID:11278322
located_inGO:0005615 extracellular space PMID:11278322
PR:O00292-1 hLEFTY2/iso:1 acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:10053005
GO:0007309 oocyte axis specification PMID:10053005