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Protein Ontology report - retinoblastoma-like protein 2 isoform 1
PR:000000306 - http://purl.obolibrary.org/obo/PR_000000306
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000306   
  PRO nameretinoblastoma-like protein 2 isoform 1 
  Synonyms
PRO-Short-label: EXACT:RBL2/iso:1
  Definition"A retinoblastoma-like protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08999-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000119 retinoblastoma-like protein 2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification4                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000306
retinoblastoma-like protein 2 isoform 1
RBL2/iso:1
"A retinoblastoma-like protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08999-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:Q08999-1
retinoblastoma-like protein 2 isoform 1 (human)
hRBL2/iso:1
"A retinoblastoma-like protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036471
retinoblastoma-like protein 2 isoform 1 phosphorylated 1 (human)
hRBL2/iso:1/Phos:1
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
organism-modification


PR:000036472
retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human)
hRBL2/iso:1/Phos:2
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 2 in human. UniProtKB:Q08999-1, Ser-672, MOD:00046." [PMID:12006580, PRO:CNA]
Yes
organism-modification


PR:000036473
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (human)
hRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in human. UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
organism-sequence


PR:Q64700-1
retinoblastoma-like protein 2 isoform 1 (mouse)
mRBL2/iso:1
"A retinoblastoma-like protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036474
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (mouse)
mRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in mouse." [PMID:10082561, PRO:CNA]
Yes
modification


PR:000000459
retinoblastoma-like protein 2 isoform 1 phosphorylated form
RBL2/iso:1/PhosRes+
"A retinoblastoma-like protein 2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000560
retinoblastoma-like protein 2 isoform 1 phosphorylated 1
RBL2/iso:1/Phos:1
"A retinoblastoma-like protein 2 isoform 1 phosphorylated form in which the phosphorylation occurs during Go/G1-S phase progression. Example: UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046." [PRO:CNA, PRO:DAN]

organism-modification


PR:000036471
retinoblastoma-like protein 2 isoform 1 phosphorylated 1 (human)
hRBL2/iso:1/Phos:1
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
modification


PR:000000561
retinoblastoma-like protein 2 isoform 1 phosphorylated 2
RBL2/iso:1/Phos:2
"A retinoblastoma-like protein 2 isoform 1 phosphorylated form that has Cdk-dependent G1 phosphorylation, and additionally phosphorylated on a Ser residue within the region linking the retinoblastoma-associated protein A and B domains, by cyclin Cdk4(6). This phosphorylation leads to ubiquitin-dependent proteolysis." [PMID:12006580, PMID:12435635]

organism-modification


PR:000036472
retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human)
hRBL2/iso:1/Phos:2
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 2 in human. UniProtKB:Q08999-1, Ser-672, MOD:00046." [PMID:12006580, PRO:CNA]
Yes
modification


PR:000000562
retinoblastoma-like protein 2 isoform 1 phosphorylated 3
RBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 that has been phosphorylated on residues at positions equivalent to Ser-639, Ser-952, Ser-966, Ser-971, Ser-972, Ser-973, Thr-974, Ser-981, Ser-982, and Thr-986 of the amino acid sequence represented by UniProtKB:Q08999-1 or a 1:1 ortholog thereof. Example: UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047." [PRO:CNA, PRO:DAN]

organism-modification


PR:000036473
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (human)
hRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in human. UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA]
Yes
organism-modification


PR:000036474
retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (mouse)
mRBL2/iso:1/Phos:3
"A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in mouse." [PMID:10082561, PRO:CNA]
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036471 hRBL2/iso:1/Phos:1
UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:11042701; PMID:11157749; PMID:8710362
enablesNOT GO:0005515 protein binding PMID:11157749
NOT GO:0030308 negative regulation of cell growth PMID:11157749
PR:000036472 hRBL2/iso:1/Phos:2
UniProtKB:Q08999-1, Ser-672, MOD:00046		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:12006580
enablesGO:0005515 protein binding with PR:Q13309 cyclin-A/CDK2-associated protein p45 (human) PMID:12006580
NOT GO:0030308 negative regulation of cell growth PMID:12006580
PR:000036473 hRBL2/iso:1/Phos:3
UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:11042701; PMID:11157749; PMID:8710362
enablesGO:0005515 protein binding with PR:Q16254 E2F-4 (human) PMID:11042701; PMID:11157749
PR:000036474 mRBL2/iso:1/Phos:3 located_inGO:0005667 transcription factor complex PMID:10082561
PR:Q08999-1 hRBL2/iso:1 enablesGO:0005515 protein binding PMID:8361765
PR:Q64700-1 mRBL2/iso:1 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:10082561
enablesGO:0030308 negative regulation of cell growth PMID:10082561
located_inGO:0005634 nucleus PMID:10082561