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Protein Ontology report - Rho-associated protein kinase 2 isoform 1

PR:000000308 - http://purl.obolibrary.org/obo/PR_000000308

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000308

PRO name

Rho-associated protein kinase 2 isoform 1

Synonyms

PRO-Short-label:

EXACT:

ROCK2/iso:1

Definition

"A Rho-associated protein kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75116-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

Comment

Note: In resting cells, the C-terminal Rho-binding and PH domain mask the protein kinase catalytic domain, activation occurs through a conformational change.

PRO Category

sequence

Parent

PR:000000121 Rho-associated protein kinase 2

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	1	Organism-Sequence	2
Modification	5	Organism-Modification	3

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

sequence

PR:000000308 Rho-associated protein kinase 2 isoform 1

ROCK2/iso:1

organism-sequence

PR:O75116-1 Rho-associated protein kinase 2 isoform 1 (human)

hROCK2/iso:1

Yes

organism-modification

PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)

hROCK2/iso:1/Clv:1

Yes

organism-modification

PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)

hROCK2/iso:1/Phos:1

Yes

organism-modification

PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)

hROCK2/iso:1/Phos:2

Yes

organism-sequence

PR:P70336-1 Rho-associated protein kinase 2 isoform 1 (mouse)

mROCK2/iso:1

modification

PR:000000462 Rho-associated protein kinase 2 isoform 1 phosphorylated form

ROCK2/iso:1/PhosRes+

modification

PR:000000565 Rho-associated protein kinase 2 isoform 1 phosphorylated 1

ROCK2/iso:1/Phos:1

organism-modification

PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)

hROCK2/iso:1/Phos:1

Yes

modification

PR:000000566 Rho-associated protein kinase 2 isoform 1 phosphorylated 2

ROCK2/iso:1/Phos:2

organism-modification

PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)

hROCK2/iso:1/Phos:2

Yes

modification

PR:000000564 Rho-associated protein kinase 2 isoform 1 cleaved 1

ROCK2/iso:1/Clv:1

organism-modification

PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)

hROCK2/iso:1/Clv:1

Yes

modification

PR:000002530 Rho-associated protein kinase 2 isoform 1 unmodified form

ROCK2/iso:1/UnMod

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000036477 hROCK2/iso:1/Clv:1 UniProtKB:O75116-1, 1-1131	acts_upstream_of_or_within	GO:0006468 protein phosphorylation	PMID:15699075
	acts_upstream_of_or_within	GO:0030036 actin cytoskeleton organization	PMID:15699075
	enables	increased GO:0004674 protein serine/threonine kinase activity relative to PR:000002530 ROCK2/iso:1/UnMod	PMID:15699075
	located_in	GO:0005622 intracellular anatomical structure	PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1 UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046	acts_upstream_of_or_within	GO:0006468 protein phosphorylation	PMID:17446864
	enables	GO:0004674 protein serine/threonine kinase activity	PMID:17446864
	located_in	GO:0005634 nucleus	PMID:15302935
PR:000036479 hROCK2/iso:1/Phos:2 UniProtKB:O75116-1, Thr-1078, MOD:00047	acts_upstream_of_or_within	GO:0042770 signal transduction in response to DNA damage	PMID:17525332
PR:O75116-1 hROCK2/iso:1	acts_upstream_of_or_within	GO:0006468 protein phosphorylation	PMID:9933571
	acts_upstream_of_or_within	GO:0051260 protein homooligomerization	PMID:15291762
	enables	GO:0004674 protein serine/threonine kinase activity	PMID:9933571
	enables	GO:0031267 small GTPase binding	PMID:11350930
	located_in	GO:0005622 intracellular anatomical structure	PMID:16574662