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Protein Ontology report - Rho-associated protein kinase 2 isoform 1
PR:000000308 - http://purl.obolibrary.org/obo/PR_000000308
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000308   
  PRO nameRho-associated protein kinase 2 isoform 1 
  Synonyms
PRO-Short-label: EXACT:ROCK2/iso:1
  Definition"A Rho-associated protein kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75116-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  CommentNote: In resting cells, the C-terminal Rho-binding and PH domain mask the protein kinase catalytic domain, activation occurs through a conformational change. 
  PRO Categorysequence 
  ParentPR:000000121 Rho-associated protein kinase 2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000000308

Rho-associated protein kinase 2 isoform 1

ROCK2/iso:1


"A Rho-associated protein kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75116-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O75116-1

Rho-associated protein kinase 2 isoform 1 (human)

hROCK2/iso:1


"A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036477

Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)

hROCK2/iso:1/Clv:1


"A Rho-associated protein kinase 2 isoform 1 cleaved 1 in human. UniProtKB:O75116-1, 1-1131." [PMID:15699075, PRO:CNA]

Yes

organism-modification



PR:000036478

Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)

hROCK2/iso:1/Phos:1


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046." [PMID:15302935, PMID:17446864, PRO:CNA]

Yes

organism-modification



PR:000036479

Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)

hROCK2/iso:1/Phos:2


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 2 in human. UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA]

Yes

organism-sequence



PR:P70336-1

Rho-associated protein kinase 2 isoform 1 (mouse)

mROCK2/iso:1


"A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000462

Rho-associated protein kinase 2 isoform 1 phosphorylated form

ROCK2/iso:1/PhosRes+


"A Rho-associated protein kinase 2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000565

Rho-associated protein kinase 2 isoform 1 phosphorylated 1

ROCK2/iso:1/Phos:1


"A Rho-associated protein kinase 2 isoform 1 phosphorylated form in which the phosphorylation occurs within the C-terminal region by the action of serine/threonine-protein kinase PLK1." [PMID:17446864]


organism-modification



PR:000036478

Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)

hROCK2/iso:1/Phos:1


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046." [PMID:15302935, PMID:17446864, PRO:CNA]

Yes

modification



PR:000000566

Rho-associated protein kinase 2 isoform 1 phosphorylated 2

ROCK2/iso:1/Phos:2


"A Rho-associated protein kinase 2 isoform 1 phosphorylated form that has been induced by DNA damage. Example: UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA, PRO:DAN]


organism-modification



PR:000036479

Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)

hROCK2/iso:1/Phos:2


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 2 in human. UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA]

Yes

modification



PR:000000564

Rho-associated protein kinase 2 isoform 1 cleaved 1

ROCK2/iso:1/Clv:1


"A Rho-associated protein kinase 2 isoform 1 that has been cleaved in the granzyme B consensus motif [IVL][GE]xD located between the Rho binding and the PH domains, removing the C-terminus." [PRO:CNA]


organism-modification



PR:000036477

Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)

hROCK2/iso:1/Clv:1


"A Rho-associated protein kinase 2 isoform 1 cleaved 1 in human. UniProtKB:O75116-1, 1-1131." [PMID:15699075, PRO:CNA]

Yes

modification



PR:000002530

Rho-associated protein kinase 2 isoform 1 unmodified form

ROCK2/iso:1/UnMod


"A Rho-associated protein kinase 2 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036477 hROCK2/iso:1/Clv:1
UniProtKB:O75116-1, 1-1131
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:15699075
GO:0030036 actin cytoskeleton organization PMID:15699075
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002530 ROCK2/iso:1/UnMod PMID:15699075
located_inGO:0005622 intracellular anatomical structure PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1
UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:17446864
enablesGO:0004674 protein serine/threonine kinase activity PMID:17446864
located_inGO:0005634 nucleus PMID:15302935
PR:000036479 hROCK2/iso:1/Phos:2
UniProtKB:O75116-1, Thr-1078, MOD:00047
acts_upstream_of_or_withinGO:0042770 signal transduction in response to DNA damage PMID:17525332
PR:O75116-1 hROCK2/iso:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:9933571
GO:0051260 protein homooligomerization PMID:15291762
enablesGO:0004674 protein serine/threonine kinase activity PMID:9933571
GO:0031267 small GTPase binding PMID:11350930
located_inGO:0005622 intracellular anatomical structure PMID:16574662