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Protein Ontology report - E3 ubiquitin-protein ligase SMURF2
PR:000000362 - http://purl.obolibrary.org/obo/PR_000000362
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000362   
  PRO nameE3 ubiquitin-protein ligase SMURF2 
  Synonyms
PRO-Short-label: EXACT:SMURF2
Other: EXACT:HECT-type E3 ubiquitin transferase SMURF2 | SMAD ubiquitination regulatory factor 2 | smad ubiquitination regulatory factor 2 | SMAD-specific E3 ubiquitin-protein ligase 2
  Definition"A smad ubiquitination regulatory factor that is a translation product of the human SMURF2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000127 smad ubiquitination regulatory factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000362 E3 ubiquitin-protein ligase SMURF2
SMURF2

organism-gene


PR:A2A5Z6 E3 ubiquitin-protein ligase SMURF2 (mouse)
mSMURF2

organism-sequence


PR:A2A5Z6-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)
mSMURF2/iso:1

organism-sequence


PR:A2A5Z6-2 E3 ubiquitin-protein ligase SMURF2 isoform m2 (mouse)
mSMURF2/iso:m2

organism-gene


PR:A9JRZ0 E3 ubiquitin-protein ligase SMURF2 (zebrafish)
z-SMURF2

organism-gene


PR:Q9HAU4 E3 ubiquitin-protein ligase SMURF2 (human)
hSMURF2
Yes
organism-sequence


PR:Q9HAU4-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)
hSMURF2/iso:1

sequence


PR:000043363 E3 ubiquitin-protein ligase SMURF2 isoform 1
SMURF2/iso:1

organism-sequence


PR:A2A5Z6-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)
mSMURF2/iso:1

organism-sequence


PR:Q9HAU4-1 E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)
hSMURF2/iso:1

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006511 ubiquitin-dependent protein catabolic processPR:Q9HAU4 hSMURF2 PMID:14755250
GO:0017015 regulation of transforming growth factor beta receptor signaling pathwayPR:Q9HAU4 hSMURF2 PMID:11016919; PMID:11158580; PMID:11163210; PMID:15862290

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004842 ubiquitin-protein transferase activityPR:Q9HAU4 hSMURF2 PMID:14755250
GO:0005515 protein bindingPR:Q9HAU4 hSMURF2 PMID:14755250