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Protein Ontology report - smad5
PR:000000372 - http://purl.obolibrary.org/obo/PR_000000372
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000372   
  PRO namesmad5 
  Synonyms
PRO-Short-label: EXACT:SMAD5
Gene-based: RELATED:MADH5
Other: EXACT:dwarfin-C | Dwf-C | JV5-1 | MAD homolog 5 | mothers against DPP homolog 5 | SMAD 5 | SMAD family member 5 | Smad5
  Definition"A BMP receptor-regulated smad protein that is a translation product of the human SMAD5 gene or a 1:1 ortholog thereof." [PMID:10708949
  PRO Categorygene 
  ParentPR:000000038 BMP receptor-regulated smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification4                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000372

smad5

SMAD5


"A BMP receptor-regulated smad protein that is a translation product of the human SMAD5 gene or a 1:1 ortholog thereof." [PMID:10708949]


organism-gene



PR:P97454

mothers against decapentaplegic homolog 5 (mouse)

mSMAD5


"A smad5 that is encoded in the genome of mouse." [OMA:P97454, PRO:DNx]


organism-sequence



PR:P97454-1

mothers against decapentaplegic homolog 5 isoform 1 (mouse)

mSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036563

smad5 isoform 1 phosphorylated 1 (mouse)

mSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]

Yes

organism-gene



PR:Q56I99

mothers against decapentaplegic homolog 5 (chicken)

chick-SMAD5


"A smad5 that is encoded in the genome of chicken." [OMA:Q56I99, PRO:DNx, UniProtKB:Q56I99]


organism-gene



PR:Q99717

mothers against decapentaplegic homolog 5 (human)

hSMAD5


"A smad5 that is encoded in the genome of human." []


organism-sequence



PR:000029962

smad5 isoform 2 (human)

hSMAD5/iso:2


"A smad5 isoform 2 that is encoded in the genome of human." [PRO:DAN]

Yes

organism-sequence



PR:Q99717-1

mothers against decapentaplegic homolog 5 isoform 1 (human)

hSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036562

smad5 isoform 1 phosphorylated 1 (human)

hSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]

Yes

organism-modification



PR:000049289

mothers against decapentaplegic homolog 5, initiator methionine removed form (human)

hSMAD5/InitMet-


"A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed. UniProtKB:Q99717, 2-465." [PRO:DNx, Reactome:R-HSA-201431]


organism-modification



PR:000049290

mothers against decapentaplegic homolog 5, initiator methionine removed phosphorylated 1 (human)

hSMAD5/InitMet-/Phos:1


"A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 463 and 465 of the amino acid sequence represented by UniProtKB:Q99717. UniProtKB:Q99717, 2-465, Ser-463/Ser-465, MOD:00046." [PRO:DNx, Reactome:R-HSA-201432, Reactome:R-HSA-201473]


organism-gene



PR:Q9R1V3

mothers against decapentaplegic homolog 5 (rat)

rSMAD5


"A smad5 that is encoded in the genome of rat." [OMA:Q9R1V3, PRO:DNx]


organism-gene



PR:Q9W7E7

mothers against decapentaplegic homolog 5 (zebrafish)

z-SMAD5


"A smad5 that is encoded in the genome of zebrafish." [OMA:Q9W7E7, PRO:DNx]


sequence



PR:000000477

smad5 isoform 1

SMAD5/iso:1


"A smad5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99717-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P97454-1

mothers against decapentaplegic homolog 5 isoform 1 (mouse)

mSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036563

smad5 isoform 1 phosphorylated 1 (mouse)

mSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]

Yes

organism-sequence



PR:Q99717-1

mothers against decapentaplegic homolog 5 isoform 1 (human)

hSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036562

smad5 isoform 1 phosphorylated 1 (human)

hSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]

Yes

modification



PR:000000580

smad5 isoform 1 phosphorylated form

SMAD5/iso:1/PhosRes+


"A smad5 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000661

smad5 isoform 1 phosphorylated 1

SMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600]


organism-modification



PR:000036562

smad5 isoform 1 phosphorylated 1 (human)

hSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]

Yes

organism-modification



PR:000036563

smad5 isoform 1 phosphorylated 1 (mouse)

mSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]

Yes

modification



PR:000026652

smad5 isoform 1, initiator methionine removed form

SMAD5/iso:1/InitMet-


"A smad5 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


sequence



PR:000000478

smad5 isoform 2

SMAD5/iso:2


"A smad5 that is a translation product of a transcript comprising intron 6 generating a C-terminus truncated MH2 domain and a unique C-terminus sequence lacking the SSxS motif necessary for SMAD activation." [EST:AA169504, PMID:10845932, PRO:CNA, PRO:DAN]


organism-sequence



PR:000029962

smad5 isoform 2 (human)

hSMAD5/iso:2


"A smad5 isoform 2 that is encoded in the genome of human." [PRO:DAN]

Yes

modification



PR:000018297

smad5, initiator methionine removed form

SMAD5/InitMet-


"A smad5 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026652

smad5 isoform 1, initiator methionine removed form

SMAD5/iso:1/InitMet-


"A smad5 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000049289

mothers against decapentaplegic homolog 5, initiator methionine removed form (human)

hSMAD5/InitMet-


"A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed. UniProtKB:Q99717, 2-465." [PRO:DNx, Reactome:R-HSA-201431]


organism-modification



PR:000049290

mothers against decapentaplegic homolog 5, initiator methionine removed phosphorylated 1 (human)

hSMAD5/InitMet-/Phos:1


"A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 463 and 465 of the amino acid sequence represented by UniProtKB:Q99717. UniProtKB:Q99717, 2-465, Ser-463/Ser-465, MOD:00046." [PRO:DNx, Reactome:R-HSA-201432, Reactome:R-HSA-201473]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029962 hSMAD5/iso:2 enablesNOT GO:0046332 SMAD binding PMID:10845932
PR:000036562 hSMAD5/iso:1/Phos:1
UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046
acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8637600
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
PR:000036563 mSMAD5/iso:1/Phos:1
UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046
acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:16522160
located_inGO:0005634 nucleus PMID:10504300; PMID:9759503
PR:P97454-1 mSMAD5/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:16765933
GO:0030509 BMP signaling pathway PMID:16522160; PMID:16765933
located_inGO:0005737 cytoplasm PMID:10504300
PR:Q99717-1 hSMAD5/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8673135
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135