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Protein Ontology report - smad9
PR:000000375 - http://purl.obolibrary.org/obo/PR_000000375
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000375   
  PRO namesmad9 
  Synonyms
PRO-Short-label: EXACT:SMAD9
Gene-based: RELATED:MADH6 | Madh8 | MADH9 | SMAD8
Other: EXACT:MAD homolog 9 | Madh6 | mothers against DPP homolog 9 | SMAD 9 | SMAD family member 9 | smad8
  Definition"A BMP receptor-regulated smad protein that is a translation product of the human SMAD9 gene or a 1:1 ortholog thereof." [PMID:10708948
  PRO Categorygene 
  ParentPR:000000038 BMP receptor-regulated smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 4                                        
         Modification4                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000375

smad9

SMAD9


"A BMP receptor-regulated smad protein that is a translation product of the human SMAD9 gene or a 1:1 ortholog thereof." [PMID:10708948]


organism-gene



PR:O15198

mothers against decapentaplegic homolog 9 (human)

hSMAD9


"A smad9 that is encoded in the genome of human." []


organism-sequence



PR:000029959

smad9 isoform 3 (human)

hSMAD9/iso:3


"A mothers against decapentaplegic homolog 9 (human) that is a translation product of a transcript that lacks the last exon." [PMID:10583507, PRO:DAN]

Yes

organism-sequence



PR:O15198-1

mothers against decapentaplegic homolog 9 isoform A (human)

hSMAD9/iso:A


"A smad9 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028350

smad9 isoform 3 phosphorylated 1 (human)

hSMAD9/iso:3/Phos:1


"A smad9 isoform 3 phosphorylated 1 in human. UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PRO:DAN]


organism-sequence



PR:O15198-2

mothers against decapentaplegic homolog 9 isoform B (human)

hSMAD9/iso:B


"A smad9 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000049291

mothers against decapentaplegic homolog 9 phosphorylated 1 (human)

hSMAD9/Phos:1


"A mothers against decapentaplegic homolog 9 (human) that has been post-translationally modified to include phosphoserine at positions 465 and 467 of the amino acid sequence represented by UniProtKB:O15198. UniProtKB:O15198, Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-201441, Reactome:R-HSA-201474]


organism-modification



PR:000067869

mothers against decapentaplegic homolog 9 methylated 1 (human)

hSMAD9/Me:1


"A mothers against decapentaplegic homolog 9 (human) that has been methylated on the residue at the position equivalent to Cys-436 of the amino acid sequence represented by UniProtKB:O15198-1. Example: UniProtKB:O15198-1, Cys-436, MOD:00660." [IEDB_epitope:1054906, PRO:DNx]


organism-modification



PR:000085152

mothers against decapentaplegic homolog 9 methylated 2 (human)

hSMAD9/Me:2


"A mothers against decapentaplegic homolog 9 (human) that has been methylated on the residue at the position equivalent to Cys-412 of the amino acid sequence represented by UniProtKB:O15198-1. Example: UniProtKB:O15198-1, Cys-412, MOD:00660." [IEDB_epitope:1008595, PRO:DNx]


organism-gene



PR:O54835

mothers against decapentaplegic homolog 9 (rat)

rSMAD9


"A smad9 that is encoded in the genome of rat." [OMA:O54835, PRO:DNx]


organism-gene



PR:Q9JIW5

mothers against decapentaplegic homolog 9 (mouse)

mSMAD9


"A smad9 that is encoded in the genome of mouse." [OMA:Q9JIW5, PRO:DNx]


organism-sequence



PR:Q9JIW5-1

mothers against decapentaplegic homolog 9 isoform 1 (mouse)

mSMAD9/iso:1


"A smad9 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036567

smad9 isoform 1 phosphorylated 1 (mouse)

mSMAD9/iso:1/Phos:1


"A smad9 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:10814522, PMID:11163184, PMID:15542835, PRO:CNA]

Yes

sequence



PR:000000482

smad9 isoform 1

SMAD9/iso:1


"A smad9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JIW5-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O15198-2

mothers against decapentaplegic homolog 9 isoform B (human)

hSMAD9/iso:B


"A smad9 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9JIW5-1

mothers against decapentaplegic homolog 9 isoform 1 (mouse)

mSMAD9/iso:1


"A smad9 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036567

smad9 isoform 1 phosphorylated 1 (mouse)

mSMAD9/iso:1/Phos:1


"A smad9 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:10814522, PMID:11163184, PMID:15542835, PRO:CNA]

Yes

modification



PR:000000585

smad9 isoform 1 phosphorylated form

SMAD9/iso:1/PhosRes+


"A smad9 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000666

smad9 isoform 1 phosphorylated 1

SMAD9/iso:1/Phos:1


"A smad9 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:15542835]


organism-modification



PR:000036567

smad9 isoform 1 phosphorylated 1 (mouse)

mSMAD9/iso:1/Phos:1


"A smad9 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:10814522, PMID:11163184, PMID:15542835, PRO:CNA]

Yes

sequence



PR:000000484

smad9 isoform 3

SMAD9/iso:3


"A smad9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15198-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O15198-1

mothers against decapentaplegic homolog 9 isoform A (human)

hSMAD9/iso:A


"A smad9 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028350

smad9 isoform 3 phosphorylated 1 (human)

hSMAD9/iso:3/Phos:1


"A smad9 isoform 3 phosphorylated 1 in human. UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PRO:DAN]


modification



PR:000000586

smad9 isoform 3 phosphorylated form

SMAD9/iso:3/PhosRes+


"A smad9 isoform 3 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000667

smad9 isoform 3 phosphorylated 1

SMAD9/iso:3/Phos:1


"A smad9 isoform 3 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif. Example: UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PMID:17081983, PRO:CNA, PRO:DAN]


organism-modification



PR:000028350

smad9 isoform 3 phosphorylated 1 (human)

hSMAD9/iso:3/Phos:1


"A smad9 isoform 3 phosphorylated 1 in human. UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PRO:DAN]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029959 hSMAD9/iso:3 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:10583507
enablesGO:0046332 SMAD binding PMID:10583507
located_inGO:0005737 cytoplasm PMID:10583507
PR:000036567 mSMAD9/iso:1/Phos:1
UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046
acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:11163184; PMID:15542835
enablesGO:0005515 protein binding PMID:11163184; PMID:15542835
located_inGO:0005634 nucleus PMID:10814522
PR:Q9JIW5-1 mSMAD9/iso:1 acts_upstream_of_or_withinGO:0048856 anatomical structure development PMID:15899870
located_inGO:0005622 intracellular anatomical structure PMID:10814522