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Protein Ontology report - tumor necrosis factor isoform 1
PR:000000381 - http://purl.obolibrary.org/obo/PR_000000381
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000381   
  PRO nametumor necrosis factor isoform 1 
  Synonyms
PRO-Short-label: EXACT:TNF/iso:1
  Definition"A tumor necrosis factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01375-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000134 tumor necrosis factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification6                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000381 tumor necrosis factor isoform 1
TNF/iso:1

organism-sequence


PR:P01375-1 tumor necrosis factor isoform 1 (human)
hTNF/iso:1
Yes
organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036507 tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
Yes
organism-modification


PR:000036508 tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
Yes
organism-sequence


PR:P06804-1 tumor necrosis factor isoform 1 (mouse)
mTNF/iso:1

organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
modification


PR:000000496 tumor necrosis factor isoform 1 myristoylated form
TNF/iso:1/MyrRes+

modification


PR:000000606 tumor necrosis factor isoform 1 myristoylated 1
TNF/iso:1/Myr:1

organism-modification


PR:000036507 tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
Yes
modification


PR:000000497 tumor necrosis factor isoform 1 phosphorylated form
TNF/iso:1/PhosRes+

modification


PR:000000607 tumor necrosis factor isoform 1 phosphorylated 1
TNF/iso:1/Phos:1

organism-modification


PR:000036508 tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
Yes
modification


PR:000000604 tumor necrosis factor isoform 1 cleaved 1
TNF/iso:1/Clv:1

organism-modification


PR:000036504 tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
Yes
organism-modification


PR:000036505 tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
Yes
modification


PR:000000605 tumor necrosis factor isoform 1 cleaved 2
TNF/iso:1/Clv:2

organism-modification


PR:000036506 tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036504 hTNF/iso:1/Clv:1
UniProtKB:P01375-1, 77-233		 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:3856324
enablesGO:0005164 tumor necrosis factor receptor binding with PR:P19438 CD120a (human) PMID:14512626
GO:0042802 identical protein binding PMID:14512626
PR:000036505 mTNF/iso:1/Clv:1
UniProtKB:P06804-1, 80-235		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:9305915
located_inGO:0005615 extracellular space PMID:10089307
PR:000036506 mTNF/iso:1/Clv:2
UniProtKB:P06804-1, 70-235		 enablesNOT GO:0005125 cytokine activity PMID:2777790
located_inGO:0005576 extracellular region PMID:2777790
PR:000036507 hTNF/iso:1/Myr:1
UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087		 located_inGO:0016020 membrane PMID:1402651
PR:000036508 hTNF/iso:1/Phos:1
UniProtKB:P01375-1, Ser-2, MOD:00046		 located_inGO:0016020 membrane PMID:10205166
PR:P01375-1 hTNF/iso:1 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:3856324
located_inGO:0005886 plasma membrane PMID:3349526