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Protein Ontology report - tumor necrosis factor isoform 1
PR:000000381 - http://purl.obolibrary.org/obo/PR_000000381
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000381   
  PRO nametumor necrosis factor isoform 1 
  Synonyms
PRO-Short-label: EXACT:TNF/iso:1
  Definition"A tumor necrosis factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01375-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000134 tumor necrosis factor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification6                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000000381

tumor necrosis factor isoform 1

TNF/iso:1


"A tumor necrosis factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01375-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P01375-1

tumor necrosis factor isoform 1 (human)

hTNF/iso:1


"A tumor necrosis factor isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036504

tumor necrosis factor isoform 1 cleaved 1 (human)

hTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]

Yes

organism-modification



PR:000036507

tumor necrosis factor isoform 1 myristoylated 1 (human)

hTNF/iso:1/Myr:1


"A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]

Yes

organism-modification



PR:000036508

tumor necrosis factor isoform 1 phosphorylated 1 (human)

hTNF/iso:1/Phos:1


"A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]

Yes

organism-sequence



PR:P06804-1

tumor necrosis factor isoform 1 (mouse)

mTNF/iso:1


"A tumor necrosis factor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036505

tumor necrosis factor isoform 1 cleaved 1 (mouse)

mTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]

Yes

organism-modification



PR:000036506

tumor necrosis factor isoform 1 cleaved 2 (mouse)

mTNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]

Yes

modification



PR:000000496

tumor necrosis factor isoform 1 myristoylated form

TNF/iso:1/MyrRes+


"A tumor necrosis factor isoform 1 that includes at least one myristoylated residue." [PRO:CNA]


modification



PR:000000606

tumor necrosis factor isoform 1 myristoylated 1

TNF/iso:1/Myr:1


"A tumor necrosis factor isoform 1 myristoylated form that has been modified at the N-epsilon-NH2 groups of the most N-terminal Lys within the cytoplasmic domain. Example: UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651]


organism-modification



PR:000036507

tumor necrosis factor isoform 1 myristoylated 1 (human)

hTNF/iso:1/Myr:1


"A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]

Yes

modification



PR:000000497

tumor necrosis factor isoform 1 phosphorylated form

TNF/iso:1/PhosRes+


"A tumor necrosis factor isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000607

tumor necrosis factor isoform 1 phosphorylated 1

TNF/iso:1/Phos:1


"A tumor necrosis factor isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Ser within the ST[EK]S motif in the cytoplasmic domain. Example: UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166]


organism-modification



PR:000036508

tumor necrosis factor isoform 1 phosphorylated 1 (human)

hTNF/iso:1/Phos:1


"A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]

Yes

modification



PR:000000604

tumor necrosis factor isoform 1 cleaved 1

TNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 that is the soluble C-terminal portion after processing by TNF alpha converting enzyme ADAM17." [PMID:12135369]


organism-modification



PR:000036504

tumor necrosis factor isoform 1 cleaved 1 (human)

hTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]

Yes

organism-modification



PR:000036505

tumor necrosis factor isoform 1 cleaved 1 (mouse)

mTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]

Yes

modification



PR:000000605

tumor necrosis factor isoform 1 cleaved 2

TNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 that is the inactive soluble form after alternative protein processing. The resulting protein is 10 amino acids longer than the active form." [PMID:2777790, PRO:CNA, PRO:DAN]


organism-modification



PR:000036506

tumor necrosis factor isoform 1 cleaved 2 (mouse)

mTNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036504 hTNF/iso:1/Clv:1
UniProtKB:P01375-1, 77-233
acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:3856324
enablesGO:0005164 tumor necrosis factor receptor binding with PR:P19438 CD120a (human) PMID:14512626
GO:0042802 identical protein binding PMID:14512626
PR:000036505 mTNF/iso:1/Clv:1
UniProtKB:P06804-1, 80-235
acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:9305915
located_inGO:0005615 extracellular space PMID:10089307
PR:000036506 mTNF/iso:1/Clv:2
UniProtKB:P06804-1, 70-235
enablesNOT GO:0005125 cytokine activity PMID:2777790
located_inGO:0005576 extracellular region PMID:2777790
PR:000036507 hTNF/iso:1/Myr:1
UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087
located_inGO:0016020 membrane PMID:1402651
PR:000036508 hTNF/iso:1/Phos:1
UniProtKB:P01375-1, Ser-2, MOD:00046
located_inGO:0016020 membrane PMID:10205166
PR:P01375-1 hTNF/iso:1 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:3856324
located_inGO:0005886 plasma membrane PMID:3349526