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Protein Ontology report - bone morphogenetic protein 4 isoform 1
PR:000000386 - http://purl.obolibrary.org/obo/PR_000000386
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000386   
  PRO namebone morphogenetic protein 4 isoform 1 
  Synonyms
PRO-Short-label: EXACT:BMP4/iso:1
  Definition"A bone morphogenetic protein 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12644-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000165 bone morphogenetic protein 4
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000386
bone morphogenetic protein 4 isoform 1
BMP4/iso:1
"A bone morphogenetic protein 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12644-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P12644-1
bone morphogenetic protein 4 isoform 1 (human)
hBMP4/iso:1
"A bone morphogenetic protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-sequence


PR:P21275-1
bone morphogenetic protein 4 isoform 1 (mouse)
mBMP4/iso:1
"A bone morphogenetic protein 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036512
bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in mouse. UniProtKB:P21275-1, 293-408." [PMID:12631064, PMID:14623234, PMID:15381701, PRO:CNA]
Yes
modification


PR:000000609
bone morphogenetic protein 4 isoform 1, mature form
BMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1 that has had the signal peptide and propeptide removed." [PMID:12805376]

organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000036512
bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in mouse. UniProtKB:P21275-1, 293-408." [PMID:12631064, PMID:14623234, PMID:15381701, PRO:CNA]
Yes
modification


PR:000021899
bone morphogenetic protein 4 isoform 1, signal peptide removed form
BMP4/iso:1/SigPep-
"A bone morphogenetic protein 4 isoform 1 that has had the signal peptide removed." [PRO:DNx]

modification


PR:000000609
bone morphogenetic protein 4 isoform 1, mature form
BMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1 that has had the signal peptide and propeptide removed." [PMID:12805376]

organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000036512
bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in mouse. UniProtKB:P21275-1, 293-408." [PMID:12631064, PMID:14623234, PMID:15381701, PRO:CNA]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001649 osteoblast differentiationPR:000036511 hBMP4/iso:1/mature PMID:14749725
PR:000036512 mBMP4/iso:1/mature PMID:15381701
GO:0001657 ureteric bud developmentPR:000036511 hBMP4/iso:1/mature PMID:12141440
PR:000036512 mBMP4/iso:1/mature PMID:12631064
GO:0001934 positive regulation of protein phosphorylationPR:000036511 hBMP4/iso:1/mature PMID:14749725
GO:0007498 mesoderm developmentPR:000036511 hBMP4/iso:1/mature PMID:9804553
PR:P12644-1 hBMP4/iso:1 PMID:9804553
GO:0030509 BMP signaling pathwayPR:000036511 hBMP4/iso:1/mature PMID:12805376
PR:000036512 mBMP4/iso:1/mature PMID:14623234

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005102 signaling receptor bindingPR:000036511 hBMP4/iso:1/mature PMID:11401399; PMID:14660436
GO:0042803 protein homodimerization activityPR:000036511 hBMP4/iso:1/mature PMID:12805376

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036511 hBMP4/iso:1/mature PMID:12805376
GO:0005622 intracellular anatomical structurePR:P12644-1 hBMP4/iso:1 PMID:12805376