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Documentation
Protein Ontology report - TGF-beta 1 sequence variant C225R (human)
PR:000000403 -
http://purl.obolibrary.org/obo/PR_000000403
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
/
GPI
PRO ID
PR:000000403
PRO name
TGF-beta 1 sequence variant C225R (human)
Synonyms
PRO-Short-label
:
EXACT:
hTGFB1/var:C225R
PRO-proteoform-std
:
EXACT:
UniProtKB:P01137
, Cys-225,
CHEBI:29952
Other
:
EXACT:
TGF-beta 1 sequence variant 6 (human)
Definition
"A transforming growth factor beta-1 (human) that has an Arg residue at the position equivalent to Cys-225 of the amino acid sequence represented by
UniProtKB:P01137
.
UniProtKB:P01137
, Cys-225,
CHEBI:29952
." [
PMID:12493741
, PRO:CNA, PRO:DAN]
PRO Category
organism-sequence
Parent
PR:P01137
transforming growth factor beta-1 (human)
Taxon
NCBITaxon:9606
Homo sapiens
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Sequence
0
Organism-Sequence
1
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
UniProtKB_VAR:VAR_017611
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
organism-sequence
PR:000000403
TGF-beta 1 sequence variant C225R (human)
hTGFB1/var:C225R
"A transforming growth factor beta-1 (human) that has an Arg residue at the position equivalent to Cys-225 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Cys-225, CHEBI:29952." [PMID:12493741, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000021906
TGF-beta 1 sequence variant C225R, signal peptide removed form (human)
hTGFB1/var:C225R/SigPep-
"A TGF-beta 1 sequence variant C225R (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Cys-225, CHEBI:29952." [PRO:DAN]
organism-modification
PR:000000625
TGF-beta 1 sequence variant C225R cleaved 1 (human)
hTGFB1/var:C225R/Clv:1
"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000000626
TGF-beta 1 sequence variant C225R cleaved 2 (human)
hTGFB1/var:C225R/Clv:2
"A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN]
Yes
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179
transforming growth factor beta receptor signaling pathway
PR:000000403
hTGFB1/var:C225R
PMID:11062463
;
PMID:12493741
;
PMID:12843182
GO:0043066
negative regulation of apoptotic process
PR:000000403
hTGFB1/var:C225R
PMID:11062463
;
PMID:12493741
;
PMID:12843182
Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:4997
Camurati-Engelmann disease
PR:000000403
hTGFB1/var:C225R
PMID:12493741
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0008083
growth factor activity
PR:000000403
hTGFB1/var:C225R
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000625
hTGFB1/var:C225R/Clv:1
PMID:11062463
;
PMID:12493741
;
PMID:12843182
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615
extracellular space
PR:000000403
hTGFB1/var:C225R
PMID:11062463
;
PMID:12493741
;
PMID:12843182
PR:000000625
hTGFB1/var:C225R/Clv:1
PMID:11062463
;
PMID:12493741
;
PMID:12843182
SO:0001561
polypeptide_partial_loss_of_function
PR:000000626
hTGFB1/var:C225R/Clv:2
PMID:11278244
