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Protein Ontology report - TGF-beta 2 isoform A

PR:000000404 - http://purl.obolibrary.org/obo/PR_000000404

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000404

PRO name

TGF-beta 2 isoform A

Synonyms

PRO-Short-label:	EXACT:	TGFB2/iso:A
Other:	RELATED:	TGF-beta 2(414) \| TGFB2 isoform A

Definition

"A TGF-beta 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P61812-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

Comment

Note: This isoform is upregulated in Alzheimer's disease.

PRO Category

sequence

Parent

PR:000000183 TGF-beta 2

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Sequence	1	Organism-Sequence	3
Modification	4	Organism-Modification	4

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

sequence

PR:000000404 TGF-beta 2 isoform A

TGFB2/iso:A

organism-sequence

PR:P27090-1 transforming growth factor beta-2 isoform 1 (mouse)

mTGFB2/iso:A

organism-modification

PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2

Yes

organism-sequence

PR:P61812-1 transforming growth factor beta-2 isoform A (human)

hTGFB2/iso:A

Yes

organism-modification

PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1

Yes

organism-modification

PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2

Yes

organism-modification

PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3

Yes

organism-sequence

PR:Q07257-2 transforming growth factor beta-2 isoform A (rat)

rTGFB2/iso:A

modification

PR:000000629 TGF-beta 2 isoform A cleaved 1

TGFB2/iso:A/Clv:1

organism-modification

PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1

Yes

modification

PR:000021908 TGF-beta 2 isoform A, signal peptide removed form

TGFB2/iso:A/SigPep-

modification

PR:000000630 TGF-beta 2 isoform A cleaved 2

TGFB2/iso:A/Clv:2

organism-modification

PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2

Yes

organism-modification

PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2

Yes

modification

PR:000000631 TGF-beta 2 isoform A cleaved 3

TGFB2/iso:A/Clv:3

organism-modification

PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000036530 hTGFB2/iso:A/Clv:1 UniProtKB:P61812-1, 303-414	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:3162913
	acts_upstream_of_or_within	GO:0008285 negative regulation of cell population proliferation	PMID:15944186
	enables	GO:0001540 amyloid-beta binding	PMID:16227582
		GO:0005160 transforming growth factor beta receptor binding	PMID:16227582
		GO:0042803 protein homodimerization activity	PMID:2119582; PMID:3476488
	located_in	GO:0005615 extracellular space	PMID:3162913
PR:000036531 mTGFB2/iso:A/Clv:2 UniProtKB:P27090-1, 20-302	enables	GO:0005515 protein binding with PR:Q07475 D0H4S114	PMID:14985127
PR:000036532 hTGFB2/iso:A/Clv:2 UniProtKB:P61812-1, 20-302	located_in	GO:0032991 protein-containing complex	PMID:3162913
PR:000036533 hTGFB2/iso:A/Clv:3 UniProtKB:P61812-1, 20-302, 303-414	enables	GO:0042803 protein homodimerization activity	PMID:3476488
	located_in	GO:0005615 extracellular space	PMID:3162913
PR:P61812-1 hTGFB2/iso:A	enables	GO:0046982 protein heterodimerization activity	PMID:2119582