back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - c-myc protein isoform 1 phosphorylated form
PR:000000422 - http://purl.obolibrary.org/obo/PR_000000422
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000422   
  PRO namec-myc protein isoform 1 phosphorylated form 
  Synonyms
PRO-Short-label: EXACT:MYC/iso:1/PhosRes+
  Definition"A c-myc protein isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] 
  PRO Categorymodification 
  ParentPR:000000228 c-myc protein isoform 1
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification5                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000000422
c-myc protein isoform 1 phosphorylated form
MYC/iso:1/PhosRes+
"A c-myc protein isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000537
c-myc protein isoform 1 phosphorylated 1
MYC/iso:1/Phos:1
"A c-myc protein isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue within the L[LY]PTLTPPLS sequence of the Myc box I within the amino-terminal regulatory domain by ERK through activation of Raf signaling pathway. Example: UniProtKB:P01106-1, Ser-62, MOD:00046." [PMID:11018017]

organism-modification


PR:000026052
c-myc protein isoform 1 phosphorylated 1 (mouse)
mMYC/iso:1/Phos:1
"A c-myc protein isoform 1 phosphorylated 1 in mouse. UniProtKB:P01108-1, Ser-62, MOD:00046." [PMID:15048125]
Yes
organism-modification


PR:000036448
c-myc protein isoform 1 phosphorylated 1 (human)
hMYC/iso:1/Phos:1
"A c-myc protein isoform 1 phosphorylated 1 in human. UniProtKB:P01106-1, Ser-62, MOD:00046." [PMID:19131971, PRO:CNA]
Yes
modification


PR:000000538
c-myc protein isoform 1 phosphorylated 2
MYC/iso:1/Phos:2
"A c-myc protein isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser and Thr residues within the L[LY]PTLTPPLS sequence of the Myc box I within the amino-terminal regulatory domain, by ERK and GSK3, respectively. Example: UniProtKB:P01106-1, Thr-58, MOD:00047|Ser-62, MOD:00046." [PMID:14563837, PMID:8386367]

organism-modification


PR:000026053
c-myc protein isoform 1 phosphorylated 2 (mouse)
mMYC/iso:1/Phos:2
"A c-myc protein isoform 1 phosphorylated 2 in mouse. UniProtKB:P01108-1, Thr-58, MOD:00047|Ser-62, MOD:00046." [PMID:14563837, PMID:15503302]
Yes
organism-modification


PR:000026054
c-myc protein isoform 1 phosphorylated 2 (human)
hMYC/iso:1/Phos:2
"A c-myc protein isoform 1 phosphorylated 2 in human. UniProtKB:P01106-1, Thr-58, MOD:00047|Ser-62, MOD:00046." [PMID:7623799]
Yes
modification


PR:000000539
c-myc protein isoform 1 phosphorylated 3
MYC/iso:1/Phos:3
"A c-myc protein isoform 1 phosphorylated form in which the phosphorylation occurs at Ser residues of the Myc box I in the amino-terminal regulatory domain by activation of ROCK proteins through Ras signaling pathway. Example: UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046." [PMID:12676581, UniProtKB:P01106]

organism-modification


PR:000026055
c-myc protein isoform 1 phosphorylated 3 (human)
hMYC/iso:1/Phos:3
"A c-myc protein isoform 1 phosphorylated 3 in human. UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046." [PMID:12676581]
Yes
modification


PR:000026040
c-myc protein isoform 1 phosphorylated 4
MYC/iso:1/Phos:4
"A c-myc protein isoform 1 phosphorylated form that is phosphorylated on a residue equivalent to Thr-58 of the amino acid sequence represented by P01106-1. It is the product of dephosphorylation of the doubly phosphorylated form (PR:000000538) by PP2A phosphatase. The phosphorylated Thr residue is important for protein stability. Example: UniProtKB:P01106-1, Thr-58, MOD:00047." [PMID:19131971, PRO:CNA, PRO:DAN]

organism-modification


PR:000026041
c-myc protein isoform 1 phosphorylated 4 (human)
hMYC/iso:1/Phos:4
"A c-myc protein isoform 1 phosphorylated 4 in human. UniProtKB:P01106-1, Thr-58, MOD:00047." [PMID:19131971]

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026052 mMYC/iso:1/Phos:1
UniProtKB:P01108-1, Ser-62, MOD:00046		 acts_upstream_of_or_withinGO:0006357 regulation of transcription by RNA polymerase II PMID:11018017
GO:0006879 intracellular iron ion homeostasis PMID:11018017
GO:0008283 cell population proliferation PMID:11018017
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:11018017
located_inGO:0005634 nucleus PMID:11018017
GO:0005667 transcription factor complex PMID:11018017
PR:000026053 mMYC/iso:1/Phos:2
UniProtKB:P01108-1, Thr-58, MOD:00047|Ser-62, MOD:00046		 located_inGO:0005634 nucleus PMID:14563837; PMID:15503302
PR:000026054 hMYC/iso:1/Phos:2
UniProtKB:P01106-1, Thr-58, MOD:00047|Ser-62, MOD:00046		 enablesNOT GO:0003700 DNA-binding transcription factor activity PMID:7623799
PR:000026055 hMYC/iso:1/Phos:3
UniProtKB:P01106-1, Ser-62/Ser-71, MOD:00046		 acts_upstream_of_or_withinGO:0045766 positive regulation of angiogenesis PMID:12676581
located_inGO:0005634 nucleus PMID:12676581
PR:000036448 hMYC/iso:1/Phos:1
UniProtKB:P01106-1, Ser-62, MOD:00046		 enablesGO:0005515 protein binding with PR:O15169-1 PMID:19131971