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Protein Ontology report - lefty 2 isoform 1
PR:000000451 - http://purl.obolibrary.org/obo/PR_000000451
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000451   
  PRO namelefty 2 isoform 1 
  Synonyms
PRO-Short-label: EXACT:LEFTY2/iso:1
  Definition"A lefty 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00292-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000288 lefty 2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000000451

lefty 2 isoform 1

LEFTY2/iso:1


"A lefty 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00292-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O00292-1

left-right determination factor 2 isoform 1 (human)

hLEFTY2/iso:1


"A lefty 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036549

lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]

Yes

organism-modification



PR:000036550

lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

organism-sequence



PR:P57785-1

left-right determination factor 2 isoform 1 (mouse)

mLEFTY2/iso:1


"A lefty 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000645

lefty 2 isoform 1 cleaved 1

LEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036549

lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1


"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]

Yes

modification



PR:000000646

lefty 2 isoform 1 cleaved 2

LEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036550

lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2


"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036549 hLEFTY2/iso:1/Clv:1
UniProtKB:O00292-1, 77-366
acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:10053005
GO:0007309 oocyte axis specification PMID:10053005
located_inGO:0005615 extracellular space PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2
UniProtKB:O00292-1, 135-366
acts_upstream_of_or_withinGO:0043406 positive regulation of MAP kinase activity PMID:11278322
located_inGO:0005615 extracellular space PMID:11278322
PR:O00292-1 hLEFTY2/iso:1 acts_upstream_of_or_withinGO:0007275 multicellular organism development PMID:10053005
GO:0007309 oocyte axis specification PMID:10053005