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Protein Ontology report - smad2 isoform Long
PR:000000468 - http://purl.obolibrary.org/obo/PR_000000468
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000468   
  PRO namesmad2 isoform Long 
  Synonyms
PRO-Short-label: EXACT:SMAD2/iso:Long
Other: EXACT:mothers against decapentaplegic homolog 2 isoform 1 | smad2 isoform 1
  Definition"A smad2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15796-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000364 smad2
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification11                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000468
smad2 isoform Long
SMAD2/iso:Long
"A smad2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15796-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:Q15796-1
mothers against decapentaplegic homolog 2 isoform Long (human)
hSMAD2/iso:Long
"A smad2 isoform Long that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000025934
smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
"A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
Yes
Yes
organism-modification


PR:000025935
smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
"A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595]
Yes
Yes
organism-modification


PR:000025936
smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
"A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046." [PMID:11027280]
Yes
Yes
organism-modification


PR:000025937
smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
"A smad2 isoform Long phosphorylated 4 in human. This form is phosphorylated at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region. UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046." [PMID:10197981]
Yes
organism-modification


PR:000036554
smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
"A smad2 isoform Long acetylated and phosphorylated 1 in human. UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756, PRO:CNA]
Yes
organism-modification


PR:000045371
smad2 isoform Long unphosphorylated 1 (human)
hSMAD2/iso:Long/UnPhos:1
"A mothers against decapentaplegic homolog 2 isoform Long (human) that lacks phosphorylation on the two last Ser of the C-terminal SSxS motif in human. UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291." [PRO:CNA]
Yes
Yes
organism-sequence


PR:Q62432-1
mothers against decapentaplegic homolog 2 isoform Long (mouse)
mSMAD2/iso:Long
"A smad2 isoform Long that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000025942
smad2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
"A smad2 isoform Long phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
Yes
Yes
organism-modification


PR:000036482
smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+
"A smad2 isoform Long phosphorylated and ubiquitinated form in mouse. UniProtKB:Q62432-1, MOD:00696|MOD:01148." [PMID:15496141, PRO:CNA]

organism-modification


PR:000036555
smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
"A smad2 isoform Long phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141, PRO:CNA]
Yes
modification


PR:000000572
smad2 isoform Long acetylated and phosphorylated form
SMAD2/iso:Long/AcPhos+
"A smad2 isoform Long that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000649
smad2 isoform Long acetylated and phosphorylated 1
SMAD2/iso:Long/AcPhos:1
"A smad2 isoform Long acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated on a Lys residue within the MH1 domain by coactivators, such as CBP, PCAF and EP300. Example: UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756]

organism-modification


PR:000036554
smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
"A smad2 isoform Long acetylated and phosphorylated 1 in human. UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756, PRO:CNA]
Yes
modification


PR:000000573
smad2 isoform Long phosphorylated and ubiquitinated form
SMAD2/iso:Long/PhosUbiq+
"A smad2 isoform Long that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]

modification


PR:000000654
smad2 isoform Long phosphorylated and ubiquitinated 1
SMAD2/iso:Long/PhosUbiq:1
"A smad2 isoform Long phosphorylated and ubiquitinated form that has been phosphorylated by TGF-beta receptor activation and further ubiquitinated by NEDD4L. This form is targeted for proteosomal degradation. Example: UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141]

organism-modification


PR:000036555
smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
"A smad2 isoform Long phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141, PRO:CNA]
Yes
organism-modification


PR:000036482
smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+
"A smad2 isoform Long phosphorylated and ubiquitinated form in mouse. UniProtKB:Q62432-1, MOD:00696|MOD:01148." [PMID:15496141, PRO:CNA]

organism-modification


PR:000036555
smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
"A smad2 isoform Long phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141, PRO:CNA]
Yes
modification


PR:000000574
smad2 isoform Long phosphorylated form
SMAD2/iso:Long/PhosRes+
"A smad2 isoform Long that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000572
smad2 isoform Long acetylated and phosphorylated form
SMAD2/iso:Long/AcPhos+
"A smad2 isoform Long that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000649
smad2 isoform Long acetylated and phosphorylated 1
SMAD2/iso:Long/AcPhos:1
"A smad2 isoform Long acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated on a Lys residue within the MH1 domain by coactivators, such as CBP, PCAF and EP300. Example: UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756]

organism-modification


PR:000036554
smad2 isoform Long acetylated and phosphorylated 1 (human)
hSMAD2/iso:Long/AcPhos:1
"A smad2 isoform Long acetylated and phosphorylated 1 in human. UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046." [PMID:17074756, PRO:CNA]
Yes
modification


PR:000000573
smad2 isoform Long phosphorylated and ubiquitinated form
SMAD2/iso:Long/PhosUbiq+
"A smad2 isoform Long that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]

modification


PR:000000654
smad2 isoform Long phosphorylated and ubiquitinated 1
SMAD2/iso:Long/PhosUbiq:1
"A smad2 isoform Long phosphorylated and ubiquitinated form that has been phosphorylated by TGF-beta receptor activation and further ubiquitinated by NEDD4L. This form is targeted for proteosomal degradation. Example: UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141]

organism-modification


PR:000036555
smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
"A smad2 isoform Long phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141, PRO:CNA]
Yes
organism-modification


PR:000036482
smad2 isoform Long phosphorylated and ubiquitinated form (mouse)
mSMAD2/iso:Long/PhosUbiq+
"A smad2 isoform Long phosphorylated and ubiquitinated form in mouse. UniProtKB:Q62432-1, MOD:00696|MOD:01148." [PMID:15496141, PRO:CNA]

organism-modification


PR:000036555
smad2 isoform Long phosphorylated and ubiquitinated 1 (mouse)
mSMAD2/iso:Long/PhosUbiq:1
"A smad2 isoform Long phosphorylated and ubiquitinated 1 in mouse. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148." [PMID:15496141, PRO:CNA]
Yes
modification


PR:000000650
smad2 isoform Long phosphorylated 1
SMAD2/iso:Long/Phos:1
"A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. Example: UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]

Yes
organism-modification


PR:000025934
smad2 isoform Long phosphorylated 1 (human)
hSMAD2/iso:Long/Phos:1
"A smad2 isoform Long phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
Yes
Yes
organism-modification


PR:000025942
smad2 isoform Long phosphorylated 1 (mouse)
mSMAD2/iso:Long/Phos:1
"A smad2 isoform Long phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046." [PMID:8980228, PMID:9346966]
Yes
Yes
modification


PR:000000651
smad2 isoform Long phosphorylated 2
SMAD2/iso:Long/Phos:2
"A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and multiple Ser and/or Thr residues in the linker region by ERK1. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595]

Yes
organism-modification


PR:000025935
smad2 isoform Long phosphorylated 2 (human)
hSMAD2/iso:Long/Phos:2
"A smad2 isoform Long phosphorylated 2 in human. This form is phosphorylated at the N-terminal Px[ST]P motif, multiple Ser and/or Thr residues in the linker region and the SSxS C-terminal motif. Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046." [PMID:12193595]
Yes
Yes
modification


PR:000000652
smad2 isoform Long phosphorylated 3
SMAD2/iso:Long/Phos:3
"A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at a [S/T] residue within the MH1-MH2 domain linker region in response to decorin-induced Ca(2+) signaling." [PMID:11027280]

Yes
organism-modification


PR:000025936
smad2 isoform Long phosphorylated 3 (human)
hSMAD2/iso:Long/Phos:3
"A smad2 isoform Long phosphorylated 3 in human. This form is phosphorylated on a [S/T] residue within the MH1-MH2 domain linker region, in addition to the two last Ser residues of the SSxS C-terminal motif. UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046." [PMID:11027280]
Yes
Yes
modification


PR:000000653
smad2 isoform Long phosphorylated 4
SMAD2/iso:Long/Phos:4
"A smad2 isoform Long phosphorylated form in which the phosphorylation occurs at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region through the MAP kinase cascade in the oncogenic Ras-activated pathway. Example: UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046." [PMID:10197981]

organism-modification


PR:000025937
smad2 isoform Long phosphorylated 4 (human)
hSMAD2/iso:Long/Phos:4
"A smad2 isoform Long phosphorylated 4 in human. This form is phosphorylated at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region. UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046." [PMID:10197981]
Yes
modification


PR:000002570
smad2 isoform Long unmodified form
SMAD2/iso:Long/UnMod
"A smad2 isoform Long that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]

Yes
modification


PR:000026718
smad2 isoform Long, initiator methionine removed form
SMAD2/iso:Long/InitMet-
"A smad2 isoform Long that has had the initiator methionine removed." [PRO:DNx]

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SMAD2/iso:Long forms found in complexes   

SMAD2/iso:Long Component
 Complexes
PR:000000650 SMAD2/iso:Long/Phos:1 PR:000025967 smad2-smad4 protein complex 1
PR:000025971 smad2-smad4-ski protein complex 1
PR:000000651 SMAD2/iso:Long/Phos:2 PR:000025969 smad2-smad4 protein complex 3
PR:000000652 SMAD2/iso:Long/Phos:3 PR:000025970 smad2-smad4 protein complex 4
PR:000002570 SMAD2/iso:Long/UnMod PR:000025972 smad2-smad4-ski protein complex 2
PR:000025934 hSMAD2/iso:Long/Phos:1 PR:000025933 smad2-smad4 protein complex 1 (human)
PR:000025951 smad2-smad4-ski protein complex 1 (human)
PR:000025935 hSMAD2/iso:Long/Phos:2 PR:000025946 smad2-smad4 protein complex 3 (human)
PR:000025936 hSMAD2/iso:Long/Phos:3 PR:000025947 smad2-smad4 protein complex 4 (human)
PR:000025942 mSMAD2/iso:Long/Phos:1 PR:000025944 smad2-smad4 protein complex 1 (mouse)
PR:000045371 hSMAD2/iso:Long/UnPhos:1 PR:000025952 smad2-smad4-ski protein complex 2 (human)
PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025934 hSMAD2/iso:Long/Phos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:15690394; PMID:9689110
GO:0007165 signal transduction PMID:8752209; PMID:8980228; PMID:9346966
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209; PMID:8980228
GO:0060395 SMAD protein signal transduction PMID:9346966
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8980228; PMID:9346966
GO:0003713 transcription coactivator activity PMID:9689110
GO:0046332 SMAD binding PMID:9311995
located_inGO:0005634 nucleus PMID:9006934; PMID:9346966
PR:000025935 hSMAD2/iso:Long/Phos:2
Example: UniProtKB:Q15796-1, Thr-8/Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255/Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:12193595
GO:0007165 signal transduction PMID:12193595
GO:0060395 SMAD protein signal transduction PMID:12193595
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:12193595
GO:0003712 transcription coregulator activity PMID:12193595
GO:0046332 SMAD binding PMID:12193595
located_inGO:0005634 nucleus PMID:12193595; PMID:17074053
PR:000025936 hSMAD2/iso:Long/Phos:3
UniProtKB:Q15796-1, Ser-240/Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11027280
GO:0060395 SMAD protein signal transduction PMID:11027280
enablesNOT GO:0003713 transcription coactivator activity PMID:11027280
GO:0046332 SMAD binding PMID:11027280
located_inGO:0005737 cytoplasm PMID:11027280
PR:000025937 hSMAD2/iso:Long/Phos:4
UniProtKB:Q15796-1, Thr-220, MOD:00047|Ser-245/Ser-250/Ser-255, MOD:00046		 enablesNOT GO:0003713 transcription coactivator activity PMID:10197981
located_inGO:0005737 cytoplasm PMID:10197981
PR:000025942 mSMAD2/iso:Long/Phos:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:11262418
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:11262418
enablesGO:0003713 transcription coactivator activity PMID:15282343
GO:0046332 SMAD binding PMID:11043574
located_inGO:0005634 nucleus PMID:11557747
PR:000036554 hSMAD2/iso:Long/AcPhos:1
UniProtKB:Q15796-1, Lys-19, MOD:00064|Ser-465/Ser-467, MOD:00046		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:17074756
GO:0007165 signal transduction PMID:17074756
located_inGO:0005634 nucleus PMID:17074756
PR:000036555 mSMAD2/iso:Long/PhosUbiq:1
UniProtKB:Q62432-1, Ser-465/Ser-467, MOD:00046|MOD:01148		 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:15496141
enablesNOT GO:0003713 transcription coactivator activity PMID:15496141
PR:000045371 hSMAD2/iso:Long/UnPhos:1
UniProtKB:Q15796-1, Ser-465/Ser-467, PR:000026291		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:8752209
enablesGO:0005515 protein binding PMID:8980228
located_inGO:0005737 cytoplasm PMID:15280432; PMID:17074053
GO:0005769 early endosome PMID:12356868
PR:Q62432-1 mSMAD2/iso:Long acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11557747
located_inGO:0005737 cytoplasm PMID:14701940