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Protein Ontology report - smad3 isoform 1
PR:000000475 - http://purl.obolibrary.org/obo/PR_000000475
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000475   
  PRO namesmad3 isoform 1 
  Synonyms
PRO-Short-label: EXACT:SMAD3/iso:1
  Definition"A smad3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000365 smad3
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification6                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
sequence


PR:000000475 smad3 isoform 1
SMAD3/iso:1

organism-sequence


PR:P84022-1 mothers against decapentaplegic homolog 3 isoform 1 (human)
hSMAD3/iso:1
Yes
organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
organism-sequence


PR:Q8BUN5-1 mothers against decapentaplegic homolog 3 isoform 1 (mouse)
mSMAD3/iso:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
Yes
organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
Yes
modification


PR:000000577 smad3 isoform 1 acetylated and phosphorylated form
SMAD3/iso:1/AcPhos+

modification


PR:000000657 smad3 isoform 1 acetylated and phosphorylated 1
SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000578 smad3 isoform 1 phosphorylated form
SMAD3/iso:1/PhosRes+

modification


PR:000000577 smad3 isoform 1 acetylated and phosphorylated form
SMAD3/iso:1/AcPhos+

modification


PR:000000657 smad3 isoform 1 acetylated and phosphorylated 1
SMAD3/iso:1/AcPhos:1

organism-modification


PR:000036557 smad3 isoform 1 acetylated and phosphorylated 1 (human)
hSMAD3/iso:1/AcPhos:1
Yes
modification


PR:000000658 smad3 isoform 1 phosphorylated 1
SMAD3/iso:1/Phos:1

organism-modification


PR:000026333 smad3 isoform 1 phosphorylated 1 (human)
hSMAD3/iso:1/Phos:1
Yes
organism-modification


PR:000036558 smad3 isoform 1 phosphorylated 1 (mouse)
mSMAD3/iso:1/Phos:1
Yes
modification


PR:000000659 smad3 isoform 1 phosphorylated 2
SMAD3/iso:1/Phos:2

organism-modification


PR:000036560 smad3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
Yes
modification


PR:000000660 smad3 isoform 1 phosphorylated 3
SMAD3/iso:1/Phos:3

organism-modification


PR:000036561 smad3 isoform 1 phosphorylated 3 (mouse)
mSMAD3/iso:1/Phos:3
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006366 transcription by RNA polymerase IIPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10823886
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000026333 hSMAD3/iso:1/Phos:1 PMID:8774881; PMID:9380693
PR:000036557 hSMAD3/iso:1/AcPhos:1 PMID:17074756
PR:P84022-1 hSMAD3/iso:1 PMID:8774881
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12543979

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10823886; PMID:12943993
GO:0003690 double-stranded DNA bindingPR:000036558 mSMAD3/iso:1/Phos:1 PMID:15282343
GO:0003700 DNA-binding transcription factor activityPR:000036557 hSMAD3/iso:1/AcPhos:1 PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:10823886; PMID:12943993
PR:000036560 mSMAD3/iso:1/Phos:2 PMID:15241418
NOT GO:0003713 transcription coactivator activityPR:000036561 mSMAD3/iso:1/Phos:3 PMID:10197981
GO:0005515 protein bindingPR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:P84022-1 hSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
PR:Q8BUN5-1 mSMAD3/iso:1 PMID:12154125
GO:0008134 transcription factor bindingPR:000026333 hSMAD3/iso:1/Phos:1 PMID:15084259
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:15464984; PMID:9702197
GO:0046332 SMAD bindingPR:000026333 hSMAD3/iso:1/Phos:1 PMID:15350224; PMID:9311995

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000026333 hSMAD3/iso:1/Phos:1 PMID:10846168; PMID:15280432
PR:000036557 hSMAD3/iso:1/AcPhos:1 PMID:17074756
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:12943993; PMID:15282343
GO:0005667 transcription factor complexPR:000026333 hSMAD3/iso:1/Phos:1 PMID:12374795
PR:000036558 mSMAD3/iso:1/Phos:1 PMID:9702197
GO:0005737 cytoplasmPR:000036561 mSMAD3/iso:1/Phos:3 PMID:10197981
PR:P84022-1 hSMAD3/iso:1 PMID:17074053