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Protein Ontology report - smad5 isoform 1
PR:000000477 - http://purl.obolibrary.org/obo/PR_000000477
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000477   
  PRO namesmad5 isoform 1 
  Synonyms
PRO-Short-label: EXACT:SMAD5/iso:1
  Definition"A smad5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99717-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000372 smad5
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000000477

smad5 isoform 1

SMAD5/iso:1


"A smad5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99717-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P97454-1

mothers against decapentaplegic homolog 5 isoform 1 (mouse)

mSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036563

smad5 isoform 1 phosphorylated 1 (mouse)

mSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]

Yes

organism-sequence



PR:Q99717-1

mothers against decapentaplegic homolog 5 isoform 1 (human)

hSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036562

smad5 isoform 1 phosphorylated 1 (human)

hSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]

Yes

modification



PR:000000580

smad5 isoform 1 phosphorylated form

SMAD5/iso:1/PhosRes+


"A smad5 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000661

smad5 isoform 1 phosphorylated 1

SMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600]


organism-modification



PR:000036562

smad5 isoform 1 phosphorylated 1 (human)

hSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]

Yes

organism-modification



PR:000036563

smad5 isoform 1 phosphorylated 1 (mouse)

mSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]

Yes

modification



PR:000026652

smad5 isoform 1, initiator methionine removed form

SMAD5/iso:1/InitMet-


"A smad5 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036562 hSMAD5/iso:1/Phos:1
UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046
acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8637600
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
PR:000036563 mSMAD5/iso:1/Phos:1
UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046
acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:16522160
located_inGO:0005634 nucleus PMID:10504300; PMID:9759503
PR:P97454-1 mSMAD5/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:16765933
GO:0030509 BMP signaling pathway PMID:16522160; PMID:16765933
located_inGO:0005737 cytoplasm PMID:10504300
PR:Q99717-1 hSMAD5/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8673135
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135