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Protein Ontology report - TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
PR:000000523 -
http://purl.obolibrary.org/obo/PR_000000523
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000523
PRO name
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
Synonyms
PRO-Short-label
:
EXACT:
TGFBR1/iso:1/SigPep-/Phos:1
Other
:
EXACT:
TGFBR1 active
Definition
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example:
UniProtKB:P36897-1
, 34-503, Ser-165/Ser-187/Ser-189/Ser-191,
MOD:00046
|Thr-185/Thr-186,
MOD:00047
." [
PMID:7774578
,
PMID:8947046
]
PRO Category
modification
Parent
PR:000000408
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000523
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
TGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
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TGFBR1/iso:1/SigPep-/Phos:1
forms found in complexes
TGFBR1/iso:1/SigPep-/Phos:1
Component
Complexes
PR:000000523
TGFBR1/iso:1/SigPep-/Phos:1
PR:000025975
transforming growth factor beta type I receptor homodimeric complex phosphorylated form
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PR:000025961
transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006468
protein phosphorylation
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PMID:7774578
PR:000036434
mTGFBR1/iso:1/SigPep-/Phos:1
PMID:12065756
GO:0007165
signal transduction
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PMID:8242743
GO:0007181
transforming growth factor beta receptor complex assembly
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PMID:8947046
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005025
transforming growth factor beta receptor activity, type I
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PMID:7774578
;
PMID:8947046
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886
plasma membrane
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PMID:8947046
