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Protein Ontology report - smad2 isoform Short phosphorylated form
PR:000000576 - http://purl.obolibrary.org/obo/PR_000000576
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000576   
  PRO namesmad2 isoform Short phosphorylated form 
  Synonyms
PRO-Short-label: EXACT:SMAD2/iso:Short/PhosRes+
  Definition"A smad2 isoform Short that includes at least one phosphorylated residue." [PRO:CNA] 
  PRO Categorymodification 
  ParentPR:000000469 smad2 isoform Short
PR:000037070 phosphoprotein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification4                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000000576
smad2 isoform Short phosphorylated form
SMAD2/iso:Short/PhosRes+
"A smad2 isoform Short that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000575
smad2 isoform Short acetylated and phosphorylated form
SMAD2/iso:Short/AcPhos+
"A smad2 isoform Short that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000655
smad2 isoform Short acetylated and phosphorylated 1
SMAD2/iso:Short/AcPhos:1
"A smad2 isoform Short acetylated and phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation and acetylated in a Lys residue within the MH1 domain by coactivators, such as CBP, PCAF and EP300. Example: UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756]

organism-modification


PR:000036556
smad2 isoform Short acetylated and phosphorylated 1 (human)
hSMAD2/iso:Short/AcPhos:1
"A smad2 isoform Short acetylated and phosphorylated 1 in human. UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046." [PMID:17074756, PRO:CNA]
Yes
modification


PR:000000656
smad2 isoform Short phosphorylated 1
SMAD2/iso:Short/Phos:1
"A smad2 isoform Short phosphorylated form in which the phosphorylation occurs at the last two Ser residues within the SSxS C-terminal motif by TGF-beta pathway activation. Example: UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PMID:15630024, PMID:17074756, PMID:9873005]

Yes
organism-modification


PR:000025938
smad2 isoform Short phosphorylated 1 (human)
hSMAD2/iso:Short/Phos:1
"A smad2 isoform Short phosphorylated 1 in human. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]
Yes
Yes
organism-modification


PR:000025943
smad2 isoform Short phosphorylated 1 (mouse)
mSMAD2/iso:Short/Phos:1
"A smad2 isoform Short phosphorylated 1 in mouse. This form is phosphorylated in the two last Ser of the C-terminal SSxS motif. UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046." [PRO:CNA]
Yes
Yes
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SMAD2/iso:Short/PhosRes+ forms found in complexes   

SMAD2/iso:Short/PhosRes+ Component
 Complexes
PR:000000656 SMAD2/iso:Short/Phos:1 PR:000025968 smad2-smad4 protein complex 2
PR:000025938 hSMAD2/iso:Short/Phos:1 PR:000025940 smad2-smad4 protein complex 2 (human)
PR:000025943 mSMAD2/iso:Short/Phos:1 PR:000025945 smad2-smad4 protein complex 2 (mouse)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000025938 hSMAD2/iso:Short/Phos:1
UniProtKB:Q15796-2, Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:9873005
enablesGO:0003677 DNA binding PMID:14701940; PMID:9873005
GO:0003700 DNA-binding transcription factor activity PMID:9873005
GO:0003712 transcription coregulator activity PMID:14701940; PMID:9873005
PR:000025943 mSMAD2/iso:Short/Phos:1
UniProtKB:Q62432-2, Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:15630024
enablesGO:0003700 DNA-binding transcription factor activity PMID:15630024
PR:000036556 hSMAD2/iso:Short/AcPhos:1
UniProtKB:Q15796-2, Lys-19, MOD:00064|Ser-435/Ser-437, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:17074756
enablesGO:0003677 DNA binding PMID:17074756
increased GO:0003700 DNA-binding transcription factor activity relative to PR:000000656 SMAD2/iso:Short/Phos:1 PMID:17074756