back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - thrombospondin-1 isoform 1, signal peptide removed form
PR:000000587 - http://purl.obolibrary.org/obo/PR_000000587
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000587   
  PRO namethrombospondin-1 isoform 1, signal peptide removed form 
  Synonyms
PRO-Short-label: EXACT:THBS1/iso:1/SigPep-
Other: EXACT:thrombospondin-1 isoform 1 cleaved 1
  Definition"A thrombospondin-1 isoform 1 that has had the signal peptide removed." [PRO:CNA] 
  PRO Categorymodification 
  ParentPR:000000376 thrombospondin-1 isoform 1
PR:000018282 thrombospondin-1, signal peptide removed form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification4                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
modification



PR:000000587

thrombospondin-1 isoform 1, signal peptide removed form

THBS1/iso:1/SigPep-


"A thrombospondin-1 isoform 1 that has had the signal peptide removed." [PRO:CNA]


modification



PR:000000485

thrombospondin-1 isoform 1 cleaved and glycosylated form

THBS1/iso:1/ClvGlyco+


"A thrombospondin-1 isoform 1, signal peptide removed form that has been processed by proteolytic cleavage and includes at least one glycosylated residue." [PRO:CNA]


modification



PR:000000590

thrombospondin-1 isoform 1 cleaved 2 glycosylated form

THBS1/iso:1/Clv:2/GlycoRes+


"A thrombospondin-1 isoform 1 cleaved and glycosylated form that has been proteolytically processed by ADAMTS1 to render a C-terminal domain product." [PMID:17082774]


organism-modification



PR:000036489

thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)

hTHBS1/iso:1/Clv:2/Glyco:1


"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in human and that has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PRO:CNA]


organism-modification



PR:000036490

thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)

mTHBS1/iso:1/Clv:2/GlycoRes+


"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in mouse. UniProtKB:P35441-1, 312-1170, MOD:00693." [PMID:17082774, PRO:CNA]

Yes

modification



PR:000000589

thrombospondin-1 isoform 1, signal peptide removed glycosylated form

THBS1/iso:1/SigPep-/GlycoRes+


"A thrombospondin-1 isoform 1, signal peptide removed form that has been post-translationally modified to include C-mannosylation on WxxW patterns, and O-fucosylation in CSx[ST]CG motif." [PMID:11067851, PRO:CNA]


organism-modification



PR:000036487

thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)

mTHBS1/iso:1/SigPep-/GlycoRes+


"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P35441-1, 19-1170, MOD:00222|MOD:00812|MOD:00813." [PMID:1459996, PMID:9657149, PRO:CNA]

Yes

organism-modification



PR:000036488

thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)

hTHBS1/iso:1/SigPep-/Glyco:1


"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]

Yes

organism-modification



PR:000026338

thrombospondin-1 isoform 1, signal peptide removed form (human)

hTHBS1/iso:1/SigPep-


"A thrombospondin-1 isoform 1, signal peptide removed form in human. UniProtKB:P07996-1, 19-1170." [PRO:DNx, UniProtKB:P07996]

Yes

organism-modification



PR:000036488

thrombospondin-1 isoform 1, signal peptide removed glycosylated 1 (human)

hTHBS1/iso:1/SigPep-/Glyco:1


"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form that is in human and has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 19-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PMID:12450399, PMID:15342643, PMID:3305519, PRO:CNA]

Yes

organism-modification



PR:000036489

thrombospondin-1 isoform 1 cleaved 2 glycosylated 1 (human)

hTHBS1/iso:1/Clv:2/Glyco:1


"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in human and that has been post-translationally modified at four Trp residues, one Ser residue, and two Thr residues. UniProtKB:P07996-1, 312-1170, Trp-385/Trp-438/Trp-441/Trp-498, MOD:00222|Ser-394, MOD:00812|Thr-450/Thr-507, MOD:00813." [PMID:11067851, PRO:CNA]


organism-modification



PR:000036485

thrombospondin-1 isoform 1, signal peptide removed form (mouse)

mTHBS1/iso:1/SigPep-


"A thrombospondin-1 isoform 1, signal peptide removed form in mouse. UniProtKB:P35441-1, 19-1170." [PMID:12498716, PRO:CNA]

Yes

organism-modification



PR:000036487

thrombospondin-1 isoform 1, signal peptide removed glycosylated form (mouse)

mTHBS1/iso:1/SigPep-/GlycoRes+


"A thrombospondin-1 isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P35441-1, 19-1170, MOD:00222|MOD:00812|MOD:00813." [PMID:1459996, PMID:9657149, PRO:CNA]

Yes

organism-modification



PR:000036490

thrombospondin-1 isoform 1 cleaved 2 glycosylated form (mouse)

mTHBS1/iso:1/Clv:2/GlycoRes+


"A thrombospondin-1 isoform 1 cleaved 2 glycosylated form in mouse. UniProtKB:P35441-1, 312-1170, MOD:00693." [PMID:17082774, PRO:CNA]

Yes

Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0016525 negative regulation of angiogenesisPR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+ PMID:17082774
GO:0060055 angiogenesis involved in wound healingPR:000036490 mTHBS1/iso:1/Clv:2/GlycoRes+ PMID:17082774

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0004866 endopeptidase inhibitor activityPR:000026338 hTHBS1/iso:1/SigPep- PMID:8751720
GO:0005515 protein bindingPR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+ PMID:1459996
PR:000036488 hTHBS1/iso:1/SigPep-/Glyco:1 PMID:3305519
GO:0050431 transforming growth factor beta bindingPR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+ PMID:9657149
PR:000036488 hTHBS1/iso:1/SigPep-/Glyco:1 PMID:15342643

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005615 extracellular spacePR:000026338 hTHBS1/iso:1/SigPep- PMID:15662972
PR:000036485 mTHBS1/iso:1/SigPep- PMID:12498716
PR:000036487 mTHBS1/iso:1/SigPep-/GlycoRes+ PMID:9657149