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RACE-PRO
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Documentation
Protein Ontology report - TGF-beta 1 isoform 1 inactive form
PR:000000618 -
http://purl.obolibrary.org/obo/PR_000000618
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000618
PRO name
TGF-beta 1 isoform 1 inactive form
Synonyms
PRO-Short-label
:
EXACT:
TGFB1/iso:1/inactive
Other
:
RELATED:
TGF beta latent complex | TGFb latent complex
Definition
"A TGF-beta 1 isoform 1, signal peptide removed form that has been cleaved at the dibasic cleavage site, rendering the latency associated peptide (LAP) and the mature protein non-covalently bound. This form is glycosylated mainly at either one or the two first consensus glycosylation sites within the LAP sequence. Example:
UniProtKB:P01137-1
, 30-278, 279-390, Asn-82,
MOD:00160
." [
PMID:3162913
,
PMID:3185545
, PRO:CNA, PRO:DAN]
PRO Category
modification
Parent
PR:000025454
TGF-beta 1 isoform 1, signal peptide removed form
PR:000037069
glycoprotein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Modification
1
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
Comp.
In Complex?
modification
PR:000000618
TGF-beta 1 isoform 1 inactive form
TGFB1/iso:1/inactive
organism-modification
PR:000026335
TGF-beta 1 isoform 1 inactive form (human)
hTGFB1/iso:1/inactive
Yes
organism-modification
PR:000036527
TGF-beta 1 isoform 1 inactive form (green monkey)
GrMonkey-TGFB1/iso:1/inactive
Yes
organism-modification
PR:000036529
TGF-beta 1 isoform 1 inactive form (mouse)
mTGFB1/iso:1/inactive
Yes
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179
transforming growth factor beta receptor signaling pathway
PR:000026335
hTGFB1/iso:1/inactive
PMID:3162913
PR:000036527
GrMonkey-TGFB1/iso:1/inactive
PMID:1448117
;
PMID:2677679
GO:0030879
mammary gland development
PR:000036529
mTGFB1/iso:1/inactive
PMID:1821856
Molecular Function GO Term
Protein Forms & Complexes
Evidence
NOT
GO:0005160
transforming growth factor beta receptor binding
PR:000026335
hTGFB1/iso:1/inactive
PMID:2677679
;
PMID:3162913
PR:000036527
GrMonkey-TGFB1/iso:1/inactive
PMID:1448117
GO:0042803
protein homodimerization activity
PR:000026335
hTGFB1/iso:1/inactive
PMID:3162913
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0031012
extracellular matrix
PR:000026335
hTGFB1/iso:1/inactive
PMID:17015622
;
PMID:8294500
PR:000036529
mTGFB1/iso:1/inactive
PMID:9008713
GO:0032991
protein-containing complex
PR:000026335
hTGFB1/iso:1/inactive
PMID:3162913
PR:000036527
GrMonkey-TGFB1/iso:1/inactive
PMID:1448117
;
PMID:2677679
