Protein Ontology

Home

Linked Open Data

Browse

Statistics

Download

RACE-PRO

PRO tracker

Community

PRO Consortium

Publications

Documentation

Protein Ontology report - TGF-beta 1 sequence variant R218C cleaved 1 (human)

PR:000000621 - http://purl.obolibrary.org/obo/PR_000000621

Annotations

Ontology Information

Show OBO stanza

PAF

GPI

PRO ID

PR:000000621

PRO name

TGF-beta 1 sequence variant R218C cleaved 1 (human)

Synonyms

PRO-Short-label:	EXACT:	hTGFB1/var:R218C/Clv:1
PRO-proteoform-std:	EXACT:	UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950
Other:	EXACT:	TGF-beta 1 sequence variant 3 cleaved 1 (human)

Definition

"A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN]

PRO Category

organism-modification

Parent

PR:000018292 TGF-beta 1 proteolytic cleavage product
PR:000021904 TGF-beta 1 sequence variant R218C, signal peptide removed form (human)

Taxon

NCBITaxon:9606 Homo sapiens

Term Hierarchy
Visualization

DAG:

OLS:

Back to top

Functional Annotation (GO-centric view)

Switch to PRO Centric View

Biological Process GO Term	Protein Forms & Complexes	Evidence
GO:0007179 transforming growth factor beta receptor signaling pathway	PR:000000621 hTGFB1/var:R218C/Clv:1	PMID:11062463; PMID:12493741; PMID:12843182
Molecular Function GO Term	Protein Forms & Complexes	Evidence
GO:0005160 transforming growth factor beta receptor binding	PR:000000621 hTGFB1/var:R218C/Clv:1	PMID:11278244
GO:0008083 growth factor activity	PR:000000621 hTGFB1/var:R218C/Clv:1	PMID:11062463; PMID:12493741; PMID:12843182
GO:0042803 protein homodimerization activity	PR:000000621 hTGFB1/var:R218C/Clv:1	PMID:11062463; PMID:12493741; PMID:12843182
Cellular Location GO Term	Protein Forms & Complexes	Evidence
GO:0005615 extracellular space	PR:000000621 hTGFB1/var:R218C/Clv:1	PMID:11062463; PMID:12493741; PMID:12843182