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Protein Ontology report - smad3 isoform 1 phosphorylated 2
PR:000000659 - http://purl.obolibrary.org/obo/PR_000000659
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000659   
  PRO namesmad3 isoform 1 phosphorylated 2 
  Synonyms
PRO-Short-label: EXACT:SMAD3/iso:1/Phos:2
  Definition"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and the clusters of [ST]P motifs within the MH1-MH2 domain linker region by G1 cyclin-dependent kinases (CDK4 and CDK2) leading to CDK inhibition of its transcriptional activity and antiproliferative function. Example: UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN] 
  PRO Categorymodification 
  ParentPR:000000578 smad3 isoform 1 phosphorylated form
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Modification1                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
modification


PR:000000659
smad3 isoform 1 phosphorylated 2
SMAD3/iso:1/Phos:2
"A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and the clusters of [ST]P motifs within the MH1-MH2 domain linker region by G1 cyclin-dependent kinases (CDK4 and CDK2) leading to CDK inhibition of its transcriptional activity and antiproliferative function. Example: UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]

organism-modification


PR:000036560
smad3 isoform 1 phosphorylated 2 (mouse)
mSMAD3/iso:1/Phos:2
"A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0003700 DNA-binding transcription factor activityPR:000036560 mSMAD3/iso:1/Phos:2 PMID:15241418