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Protein Ontology report - calcium-activated calmodulin-binding potassium channel alpha subunit
PR:000000668 - http://purl.obolibrary.org/obo/PR_000000668
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000668   
  PRO namecalcium-activated calmodulin-binding potassium channel alpha subunit 
  Definition"A calcium-activated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. They are subunits of the small conductance calcium-activated channels. SK channels are independent of voltage and gated solely by intracellular calcium. These membrane channels are heteromeric complexes that comprise pore-forming alpha-subunits and the calcium-binding protein calmodulin. Calmodulin binds to the SK channel through the Calmodulin binding domain (Pfam:PF02888), which is located in an intracellular region of the alpha-subunit immediately carboxy-terminal to the pore. Channel opening is triggered when calcium binds the EF hands in the N-lobe of calmodulin. These channels play a crucial role in hyperpolarizing the membrane potential of excitable and nonexcitable cells." [PMID:10026195, PMID:11323678] 
  PRO Categoryfamily 
  ParentPR:000044649 calcium-activated potassium channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 13                                        
         Sequence15                                                  Organism-Sequence 28                                        
         Modification1                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038511
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000668 calcium-activated calmodulin-binding potassium channel alpha subunit
SMAD9/iso:3/Phos:1

gene


PR:000000700 intermediate conductance calcium-activated potassium channel protein 4
KCNN4

organism-gene


PR:O15554 intermediate conductance calcium-activated potassium channel protein 4 (human)
hKCNN4
Yes
organism-sequence


PR:O15554-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)
hKCNN4/iso:1
Yes
organism-modification


PR:000071778 intermediate conductance calcium-activated potassium channel protein 4 deaminated 1 (human)
hKCNN4/Deam:1

organism-gene


PR:O89109 intermediate conductance calcium-activated potassium channel protein 4 (mouse)
mKCNN4

organism-sequence


PR:O89109-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)
mKCNN4/iso:1
Yes
organism-gene


PR:Q9QYW1 intermediate conductance calcium-activated potassium channel protein 4 (rat)
rKCNN4

sequence


PR:000000753 intermediate conductance calcium-activated potassium channel protein 4 isoform 1
KCNN4/iso:1

organism-sequence


PR:O15554-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (human)
hKCNN4/iso:1
Yes
organism-sequence


PR:O89109-1 intermediate conductance calcium-activated potassium channel protein 4 isoform 1 (mouse)
mKCNN4/iso:1
Yes
gene


PR:000000712 small conductance calcium-activated potassium channel protein 1
KCNN1

organism-gene


PR:P70606 small conductance calcium-activated potassium channel protein 1 (rat)
rKCNN1

organism-gene


PR:Q92952 small conductance calcium-activated potassium channel protein 1 (human)
hKCNN1

organism-sequence


PR:Q92952-1 small conductance calcium-activated potassium channel protein 1 isoform h1 (human)
hKCNN1/iso:h1

organism-sequence


PR:Q92952-2 small conductance calcium-activated potassium channel protein 1 isoform 2 (human)
hKCNN1/iso:2
Yes
organism-modification


PR:000084864 small conductance calcium-activated potassium channel protein 1 phosphorylated 1 (human)
hKCNN1/Phos:1

organism-gene


PR:Q9EQR3 small conductance calcium-activated potassium channel protein 1 (mouse)
mKCNN1

organism-sequence


PR:Q9EQR3-1 small conductance calcium-activated potassium channel protein 1 isoform 1 (mouse)
mKCNN1/iso:1
Yes
organism-sequence


PR:Q9EQR3-2 small conductance calcium-activated potassium channel protein 1 isoform 2 (mouse)
mKCNN1/iso:2

organism-sequence


PR:Q9EQR3-3 small conductance calcium-activated potassium channel protein 1 isoform V (mouse)
mKCNN1/iso:V
Yes
organism-sequence


PR:Q9EQR3-4 small conductance calcium-activated potassium channel protein 1 isoform VI (mouse)
mKCNN1/iso:VI
Yes
organism-sequence


PR:Q9EQR3-5 small conductance calcium-activated potassium channel protein 1 isoform VII (mouse)
mKCNN1/iso:VII
Yes
organism-sequence


PR:Q9EQR3-6 small conductance calcium-activated potassium channel protein 1 isoform VIII (mouse)
mKCNN1/iso:VIII
Yes
organism-sequence


PR:Q9EQR3-7 small conductance calcium-activated potassium channel protein 1 isoform IV (mouse)
mKCNN1/iso:IV
Yes
organism-sequence


PR:Q9EQR3-8 small conductance calcium-activated potassium channel protein 1 isoform III (mouse)
mKCNN1/iso:III
Yes
organism-sequence


PR:Q9EQR3-9 small conductance calcium-activated potassium channel protein 1 isoform II (mouse)
mKCNN1/iso:II
Yes
sequence


PR:000000761 small conductance calcium-activated potassium channel protein 1 isoform 1
KCNN1/iso:1

organism-sequence


PR:Q9EQR3-1 small conductance calcium-activated potassium channel protein 1 isoform 1 (mouse)
mKCNN1/iso:1
Yes
modification


PR:000002605 small conductance calcium-activated potassium channel protein 1 isoform 1 unmodified form
KCNN1/iso:1/UnMod

sequence


PR:000000762 small conductance calcium-activated potassium channel protein 1 isoform 2
KCNN1/iso:2

organism-sequence


PR:Q92952-2 small conductance calcium-activated potassium channel protein 1 isoform 2 (human)
hKCNN1/iso:2
Yes
sequence


PR:000000763 small conductance calcium-activated potassium channel protein 1 isoform I
KCNN1/iso:I

organism-sequence


PR:Q9EQR3-2 small conductance calcium-activated potassium channel protein 1 isoform 2 (mouse)
mKCNN1/iso:2

sequence


PR:000000764 small conductance calcium-activated potassium channel protein 1 isoform II
KCNN1/iso:II

organism-sequence


PR:Q9EQR3-9 small conductance calcium-activated potassium channel protein 1 isoform II (mouse)
mKCNN1/iso:II
Yes
sequence


PR:000000765 small conductance calcium-activated potassium channel protein 1 isoform III
KCNN1/iso:III

organism-sequence


PR:Q9EQR3-8 small conductance calcium-activated potassium channel protein 1 isoform III (mouse)
mKCNN1/iso:III
Yes
sequence


PR:000000766 small conductance calcium-activated potassium channel protein 1 isoform IV
KCNN1/iso:IV

organism-sequence


PR:Q9EQR3-7 small conductance calcium-activated potassium channel protein 1 isoform IV (mouse)
mKCNN1/iso:IV
Yes
sequence


PR:000000767 small conductance calcium-activated potassium channel protein 1 isoform V
KCNN1/iso:V

organism-sequence


PR:Q9EQR3-3 small conductance calcium-activated potassium channel protein 1 isoform V (mouse)
mKCNN1/iso:V
Yes
sequence


PR:000000768 small conductance calcium-activated potassium channel protein 1 isoform VI
KCNN1/iso:VI

organism-sequence


PR:Q9EQR3-4 small conductance calcium-activated potassium channel protein 1 isoform VI (mouse)
mKCNN1/iso:VI
Yes
sequence


PR:000000769 small conductance calcium-activated potassium channel protein 1 isoform VII
KCNN1/iso:VII

organism-sequence


PR:Q9EQR3-5 small conductance calcium-activated potassium channel protein 1 isoform VII (mouse)
mKCNN1/iso:VII
Yes
sequence


PR:000000770 small conductance calcium-activated potassium channel protein 1 isoform VIII
KCNN1/iso:VIII

organism-sequence


PR:Q9EQR3-6 small conductance calcium-activated potassium channel protein 1 isoform VIII (mouse)
mKCNN1/iso:VIII
Yes
gene


PR:000000713 small conductance calcium-activated potassium channel protein 2
KCNN2

organism-gene


PR:P58390 small conductance calcium-activated potassium channel protein 2 (mouse)
mKCNN2

organism-sequence


PR:B4YDY0 small conductance calcium-activated potassium channel protein 2 isoform 3 (mouse)
mKCNN2/iso:3
Yes
organism-sequence


PR:P58390-1 small conductance calcium-activated potassium channel protein 2 isoform 1 (mouse)
mKCNN2/iso:1
Yes
organism-gene


PR:P70604 small conductance calcium-activated potassium channel protein 2 (rat)
rKCNN2

organism-gene


PR:Q7KVW5 small conductance calcium-activated potassium channel protein (fruit fly)
fly-KCNN2

organism-sequence


PR:Q7KVW5-1 small conductance calcium-activated potassium channel protein isoform K (fruit fly)
fly-KCNN2/iso:K

organism-sequence


PR:Q7KVW5-2 small conductance calcium-activated potassium channel protein isoform J (fruit fly)
fly-KCNN2/iso:J

organism-sequence


PR:Q7KVW5-4 small conductance calcium-activated potassium channel protein isoform L (fruit fly)
fly-KCNN2/iso:L

organism-sequence


PR:Q7KVW5-5 small conductance calcium-activated potassium channel protein isoform M (fruit fly)
fly-KCNN2/iso:M

organism-sequence


PR:Q7KVW5-6 small conductance calcium-activated potassium channel protein isoform N (fruit fly)
fly-KCNN2/iso:N

organism-sequence


PR:Q7KVW5-7 small conductance calcium-activated potassium channel protein isoform I (fruit fly)
fly-KCNN2/iso:I

organism-sequence


PR:Q7KVW5-8 small conductance calcium-activated potassium channel protein isoform H (fruit fly)
fly-KCNN2/iso:H

organism-gene


PR:Q9H2S1 small conductance calcium-activated potassium channel protein 2 (human)
hKCNN2

organism-sequence


PR:Q9H2S1-1 small conductance calcium-activated potassium channel protein 2 isoform 1 (human)
hKCNN2/iso:1
Yes
organism-sequence


PR:Q9H2S1-2 small conductance calcium-activated potassium channel protein 2 isoform 2 (human)
hKCNN2/iso:2

sequence


PR:000000771 small conductance calcium-activated potassium channel protein 2 isoform 1
KCNN2/iso:1

organism-sequence


PR:P58390-1 small conductance calcium-activated potassium channel protein 2 isoform 1 (mouse)
mKCNN2/iso:1
Yes
organism-sequence


PR:Q9H2S1-1 small conductance calcium-activated potassium channel protein 2 isoform 1 (human)
hKCNN2/iso:1
Yes
sequence


PR:000000772 small conductance calcium-activated potassium channel protein 2 isoform 2
KCNN2/iso:2

organism-sequence


PR:Q9H2S1-2 small conductance calcium-activated potassium channel protein 2 isoform 2 (human)
hKCNN2/iso:2

sequence


PR:000035381 small conductance calcium-activated potassium channel protein 2 isoform 3
KCNN2/iso:3

organism-sequence


PR:B4YDY0 small conductance calcium-activated potassium channel protein 2 isoform 3 (mouse)
mKCNN2/iso:3
Yes
gene


PR:000000714 small conductance calcium-activated potassium channel protein 3
KCNN3

organism-gene


PR:P58391 small conductance calcium-activated potassium channel protein 3 (mouse)
mKCNN3

organism-gene


PR:P70605 small conductance calcium-activated potassium channel protein 3 (rat)
rKCNN3

organism-gene


PR:Q9UGI6 small conductance calcium-activated potassium channel protein 3 (human)
hKCNN3

organism-sequence


PR:000029956 small conductance calcium-activated potassium channel protein 3 sequence variant 1 (human)
hKCNN3/var:1
Yes
organism-sequence


PR:Q9UGI6-1 small conductance calcium-activated potassium channel protein 3 isoform 1 (human)
hKCNN3/iso:1
Yes
organism-sequence


PR:Q9UGI6-2 small conductance calcium-activated potassium channel protein 3 isoform h2 (human)
hKCNN3/iso:h2

organism-sequence


PR:Q9UGI6-3 small conductance calcium-activated potassium channel protein 3 isoform h3 (human)
hKCNN3/iso:h3

sequence


PR:000000773 small conductance calcium-activated potassium channel protein 3 isoform 1
KCNN3/iso:1

organism-sequence


PR:Q9UGI6-1 small conductance calcium-activated potassium channel protein 3 isoform 1 (human)
hKCNN3/iso:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029956 hKCNN3/var:1
However, it conserves the two glutamine rich domains		 enablesNOT GO:0015269 calcium-activated potassium channel activity PMID:11395478
located_inGO:0005634 nucleus PMID:11395478
PR:B4YDY0 mKCNN2/iso:3 acts_upstream_of_or_withinNOT GO:0006811 monoatomic ion transport MGI_ref:3810884; PMID:18624921
enablesNOT GO:0005216 monoatomic ion channel activity MGI_ref:3810884; PMID:18624921
located_inGO:0005886 plasma membrane MGI_ref:3810884; PMID:18624921
PR:O15554 hKCNN4 acts_upstream_of_or_withinGO:0006952 defense response PMID:11278890; PMID:9407042
enablesGO:0005516 calmodulin binding PMID:10026195
PR:O15554-1 hKCNN4/iso:1 enablesGO:0005516 calmodulin binding PMID:10026195
located_inGO:0009986 cell surface PMID:11395478
PR:O89109-1 mKCNN4/iso:1 acts_upstream_of_or_withinGO:0050714 positive regulation of protein secretion PMID:11724775
enablesGO:0015269 calcium-activated potassium channel activity PMID:11724775
PR:P58390-1 mKCNN2/iso:1 acts_upstream_of_or_withinGO:0006811 monoatomic ion transport MGI_ref:3810884; PMID:18624921
enablesGO:0005216 monoatomic ion channel activity MGI_ref:3810884; PMID:18624921
PR:Q92952-2 hKCNN1/iso:2 acts_upstream_of_or_withinGO:0007268 chemical synaptic transmission PMID:8781233
enablesGO:0005516 calmodulin binding PMID:10026195
PR:Q9EQR3-1 mKCNN1/iso:1 enablesGO:0005516 calmodulin binding PMID:11267657
PR:Q9EQR3-3 mKCNN1/iso:V enablesNOT GO:0005516 calmodulin binding PMID:11267657
PR:Q9EQR3-4 mKCNN1/iso:VI enablesNOT GO:0005516 calmodulin binding PMID:11267657
PR:Q9EQR3-5 mKCNN1/iso:VII enablesNOT GO:0005516 calmodulin binding PMID:11267657
PR:Q9EQR3-6 mKCNN1/iso:VIII enablesNOT GO:0005516 calmodulin binding PMID:11267657
PR:Q9EQR3-7 mKCNN1/iso:IV enablesdecreased GO:0005516 calmodulin binding relative to PR:000002605 KCNN1/iso:1/UnMod PMID:11267657
PR:Q9EQR3-8 mKCNN1/iso:III enablesdecreased GO:0005516 calmodulin binding relative to PR:000002605 KCNN1/iso:1/UnMod PMID:11267657
PR:Q9EQR3-9 mKCNN1/iso:II enablesGO:0005516 calmodulin binding PMID:11267657
PR:Q9H2S1-1 hKCNN2/iso:1 located_inGO:0009986 cell surface PMID:11395478
PR:Q9UGI6-1 hKCNN3/iso:1 located_inGO:0009986 cell surface PMID:11395478