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PRO ID
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| PRO name | cation channel sperm-associated protein 1 |
| Synonyms | | PRO-Short-label: | EXACT: | CATSPER1 | | Other: | EXACT: | CatSper1 | | | |
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| Definition | "A CatSper channel protein that is a translation product of the human CATSPER1 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper1 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. Unique to this class is the His-rich N terminus that seems to be involved the pH sensitivity of the channel calcium currents." [PRO:CNA] |
| PRO Category | gene |
| Parent | PR:000044645 CatSper channel protein
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| Terms by PRO Category |
| Organism-Independent |
Organism-Specific |
| Category |
Number of Terms |
Category |
Number of Terms | | Gene | 1 |
Organism-Gene |
2 |
| Sequence | 1 |
Organism-Sequence |
2 | | Modification | 1 |
Organism-Modification |
0 | | | |
Term Hierarchy
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