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gene
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PR:000000669 |
cation channel sperm-associated protein 1
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CATSPER1
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"A CatSper channel protein that is a translation product of the human CATSPER1 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper1 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. Unique to this class is the His-rich N terminus that seems to be involved the pH sensitivity of the channel calcium currents." [PRO:CNA]
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organism-gene
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PR:Q8NEC5 |
cation channel sperm-associated protein 1 (human)
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hCATSPER1
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"A cation channel sperm-associated protein 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8NEC5]
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organism-sequence
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PR:Q8NEC5-1 |
cation channel sperm-associated protein 1 isoform 1 (human)
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hCATSPER1/iso:1
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"A cation channel sperm-associated protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NEC5-1." [PRO:DNx, UniProtKB:Q8NEC5]
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Yes |
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organism-gene
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PR:Q91ZR5 |
cation channel sperm-associated protein 1 (mouse)
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mCATSPER1
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"A cation channel sperm-associated protein 1 that is encoded in the genome of mouse." [OMA:Q91ZR5, PRO:DNx]
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Yes |
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organism-sequence
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PR:Q91ZR5-1 |
cation channel sperm-associated protein 1 isoform 1 (mouse)
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mCATSPER1/iso:1
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"A cation channel sperm-associated protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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sequence
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PR:000000688 |
cation channel sperm-associated protein 1 isoform 1
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CATSPER1/iso:1
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"A cation channel sperm-associated protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q91ZR5-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:Q91ZR5-1 |
cation channel sperm-associated protein 1 isoform 1 (mouse)
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mCATSPER1/iso:1
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"A cation channel sperm-associated protein 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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modification
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PR:000002581 |
cation channel sperm-associated protein 1 isoform 1 unmodified form
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CATSPER1/iso:1/UnMod
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"A cation channel sperm-associated protein 1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
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