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Protein Ontology report - cation channel sperm-associated protein 2
PR:000000670 - http://purl.obolibrary.org/obo/PR_000000670
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000670   
  PRO namecation channel sperm-associated protein 2 
  Synonyms
PRO-Short-label: EXACT:CATSPER2
Other: EXACT:CatSper2
  Definition"A CatSper channel protein that is a translation product of the human CATSPER2 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper2 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000044645 CatSper channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence4                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:389
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000670

cation channel sperm-associated protein 2

CATSPER2


"A CatSper channel protein that is a translation product of the human CATSPER2 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper2 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane." [PRO:CNA]


organism-gene



PR:A2ARP9

cation channel sperm-associated protein 2 (mouse)

mCATSPER2


"A cation channel sperm-associated protein 2 that is encoded in the genome of mouse." [OMA:A2ARP9, PRO:DNx]

Yes

organism-sequence



PR:A2ARP9-1

cation channel sperm-associated protein 2 isoform m1 (mouse)

mCATSPER2/iso:m1


"A cation channel sperm-associated protein 2 isoform m1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:Q6AXP6

cation channel sperm-associated protein 2 (rat)

rCATSPER2


"A cation channel sperm-associated protein 2 that is encoded in the genome of rat." [OMA:Q6AXP6, PRO:DNx]


organism-gene



PR:Q96P56

cation channel sperm-associated protein 2 (human)

hCATSPER2


"A cation channel sperm-associated protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96P56]


organism-sequence



PR:Q96P56-1

cation channel sperm-associated protein 2 isoform 1 (human)

hCATSPER2/iso:1


"A cation channel sperm-associated protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q96P56-2

cation channel sperm-associated protein 2 isoform 2 (human)

hCATSPER2/iso:2


"A cation channel sperm-associated protein 2 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q96P56-3

cation channel sperm-associated protein 2 isoform 3 (human)

hCATSPER2/iso:3


"A cation channel sperm-associated protein 2 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q96P56-4

cation channel sperm-associated protein 2 isoform h4 (human)

hCATSPER2/iso:h4


"A cation channel sperm-associated protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P56-4." [PRO:DNx, UniProtKB:Q96P56]


sequence



PR:000000689

cation channel sperm-associated protein 2 isoform 1

CATSPER2/iso:1


"A cation channel sperm-associated protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P56-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q96P56-1

cation channel sperm-associated protein 2 isoform 1 (human)

hCATSPER2/iso:1


"A cation channel sperm-associated protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000690

cation channel sperm-associated protein 2 isoform 2

CATSPER2/iso:2


"A cation channel sperm-associated protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P56-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q96P56-2

cation channel sperm-associated protein 2 isoform 2 (human)

hCATSPER2/iso:2


"A cation channel sperm-associated protein 2 isoform 2 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000691

cation channel sperm-associated protein 2 isoform 3

CATSPER2/iso:3


"A cation channel sperm-associated protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96P56-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q96P56-3

cation channel sperm-associated protein 2 isoform 3 (human)

hCATSPER2/iso:3


"A cation channel sperm-associated protein 2 isoform 3 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000692

cation channel sperm-associated protein 2 isoform m1

CATSPER2/iso:m1


"A cation channel sperm-associated protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2ARP9-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:A2ARP9-1

cation channel sperm-associated protein 2 isoform m1 (mouse)

mCATSPER2/iso:m1


"A cation channel sperm-associated protein 2 isoform m1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:A2ARP9 mCATSPER2 acts_upstream_of_or_withinGO:0001539 cilium or flagellum-dependent cell motility PMID:14657366
GO:0030317 flagellated sperm motility PMID:14657366; PMID:17174296; PMID:17227845
PR:A2ARP9-1 mCATSPER2/iso:m1 located_inGO:0031514 motile cilium PMID:11675491; PMID:14657366
PR:Q96P56-1 hCATSPER2/iso:1 enablesGO:0005515 protein binding with PR:Q9P0X4 Ca(v)3.3 (human) PMID:16740636