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Protein Ontology report - cyclic nucleotide-gated channel alpha subunit
PR:000000673 - http://purl.obolibrary.org/obo/PR_000000673
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000673   
  PRO namecyclic nucleotide-gated channel alpha subunit 
  Definition"A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The carboxy-terminal region contains the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) and a region connecting the CNBD to the S6 segment (C-linker), which is important for modulation by transition metals. In addition, CNG alpha has a carboxy-terminal leucine zipper that seems to be involved in inter-subunit interaction. CNG alpha subunits combine with the beta subunits to form the cyclic nucleotide-gated ion channels, which mediate sensory transduction in photoreceptors and olfactory sensory neurons. These channels are likely composed of four subunits around a centrally located ion-permeable pore that opens in response to the direct binding of intracellular cyclic nucleotides. CNG channels are non-selective cation channels. They are not gated by membrane voltage although their structure includes the transmembrane S4 motif known to function as the membrane voltage sensor in all voltage-gated ion channels, but it has been shown to be important for proper folding and processing. Alpha and beta subunits of the CNG channel are very similar, however only alpha subunits are able to homooligomerize and form functional channels." [PMID:12432397, PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000044648 cyclic nucleotide-regulated channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 16                                        
         Sequence4                                                  Organism-Sequence 23                                        
         Modification3                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF002403
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000673

cyclic nucleotide-gated channel alpha subunit

CATSPERB


"A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The carboxy-terminal region contains the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) and a region connecting the CNBD to the S6 segment (C-linker), which is important for modulation by transition metals. In addition, CNG alpha has a carboxy-terminal leucine zipper that seems to be involved in inter-subunit interaction. CNG alpha subunits combine with the beta subunits to form the cyclic nucleotide-gated ion channels, which mediate sensory transduction in photoreceptors and olfactory sensory neurons. These channels are likely composed of four subunits around a centrally located ion-permeable pore that opens in response to the direct binding of intracellular cyclic nucleotides. CNG channels are non-selective cation channels. They are not gated by membrane voltage although their structure includes the transmembrane S4 motif known to function as the membrane voltage sensor in all voltage-gated ion channels, but it has been shown to be important for proper folding and processing. Alpha and beta subunits of the CNG channel are very similar, however only alpha subunits are able to homooligomerize and form functional channels." [PMID:12432397, PRO:CNA]


gene



PR:000000686

cyclic nucleotide-gated channel alpha-1

CNGA1


"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA1 gene or a 1:1 ortholog thereof. In the retina, these proteins can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors." [PRO:CNA]


organism-gene



PR:P29973

cyclic nucleotide-gated channel alpha-1 (human)

hCNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P29973]


organism-sequence



PR:000000738

cyclic nucleotide-gated channel alpha-1 sequence variant S320F (human)

hCNGA1/var:S320F


"A cyclic nucleotide-gated channel alpha-1 (human) that has a Phe residue at the position equivalent to Ser-320 of the amino acid sequence represented by UniProtKB:P29973-1. Example: UniProtKB:P29973-1, Ser-320, CHEBI:29997." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P29973-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (human)

hCNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000078527

cyclic nucleotide-gated channel alpha-1 deaminated 1 (human)

hCNGA1/Deam:1


"A cyclic nucleotide-gated channel alpha-1 (human) that has been deaminated on the residue at the position equivalent to Asn-159 of the amino acid sequence represented by UniProtKB:P29973. UniProtKB:P29973, Asn-159, MOD:00684." [IEDB_epitope:1327288, PRO:DNx]


organism-gene



PR:P29974

cyclic nucleotide-gated channel alpha-1 (mouse)

mCNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of mouse." [OMA:P29974, PRO:DNx]

Yes

organism-sequence



PR:P29974-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (mouse)

mCNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q00194

cyclic nucleotide-gated channel alpha-1 (cow)

cow-CNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of cow." [OMA:Q00194, PRO:DNx]


organism-sequence



PR:Q00194-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (cow)

cow-CNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of cow." [PRO:CNA]

Yes

organism-modification



PR:000036569

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)

cow-CNGA1/iso:1/Phos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]

Yes

organism-modification



PR:000045379

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)

cow-CNGA1/iso:1/Phos:2


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]


organism-modification



PR:000045381

cyclic nucleotide-gated channel alpha-1 isoform 1 unphosphorylated 1 (cow)

cow-CNGA1/iso:1/UnPhos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 (cow) that lacks phosphorylation on Tyr-498. UniProtKB:Q00194-1, Tyr-498, PR:000026291." [PMID:10366613, PRO:CNA]

Yes

organism-gene



PR:Q62927

cyclic nucleotide-gated channel alpha-1 (rat)

rCNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of rat." [OMA:Q62927, PRO:DNx]


organism-gene



PR:Q90980

cyclic nucleotide-gated channel rod photoreceptor subunit alpha (chicken)

chick-CNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of chicken." [OMA:Q90980, PRO:DNx]


sequence



PR:000000737

cyclic nucleotide-gated channel alpha-1 isoform 1

CNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29973-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P29973-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (human)

hCNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:P29974-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (mouse)

mCNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q00194-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (cow)

cow-CNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of cow." [PRO:CNA]

Yes

organism-modification



PR:000036569

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)

cow-CNGA1/iso:1/Phos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]

Yes

organism-modification



PR:000045379

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)

cow-CNGA1/iso:1/Phos:2


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]


organism-modification



PR:000045381

cyclic nucleotide-gated channel alpha-1 isoform 1 unphosphorylated 1 (cow)

cow-CNGA1/iso:1/UnPhos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 (cow) that lacks phosphorylation on Tyr-498. UniProtKB:Q00194-1, Tyr-498, PR:000026291." [PMID:10366613, PRO:CNA]

Yes

modification



PR:000000932

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form

CNGA1/iso:1/PhosRes+


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000981

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1

CNGA1/iso:1/Phos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB). Example: UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825]


organism-modification



PR:000036569

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)

cow-CNGA1/iso:1/Phos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]

Yes

modification



PR:000045378

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2

CNGA1/iso:1/Phos:2


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB) and the residue at the position equivalent to Tyr-503 of the amino acid sequence represented by UniProtKB:Q00194-1. This phosphorylation prevents Ca2+/CaM inhibition of the CNG channel, but at the same time has a similar effect, that is decreases the apparent affinity for cGMP. Example: UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:23032687, PRO:CNA, PRO:DAN]


organism-modification



PR:000045379

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)

cow-CNGA1/iso:1/Phos:2


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]


gene



PR:000000696

cyclic nucleotide-gated channel alpha-3

CNGA3


"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA3 gene or a 1:1 ortholog thereof. These proteins are the alpha subunits of the cone cyclic nucleotide-gated cation channel. This channel generates the light-evoked electrical responses of cone photoreceptors." [PRO:CNA]


organism-gene



PR:Q16281

cyclic nucleotide-gated channel alpha-3 (human)

hCNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q16281]


organism-sequence



PR:000000741

cyclic nucleotide-gated channel alpha-3 sequence variant R283Q (human)

hCNGA3/var:R283Q


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Gln residue at the position equivalent to Arg-283 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-283, CHEBI:30011." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000742

cyclic nucleotide-gated channel alpha-3 sequence variant T291R (human)

hCNGA3/var:T291R


"A cyclic nucleotide-gated channel alpha-3 (human) that has an Arg residue at the position equivalent to Thr-291 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Thr-291, CHEBI:29952." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000743

cyclic nucleotide-gated channel alpha-3 sequence variant G557R (human)

hCNGA3/var:G557R


"A cyclic nucleotide-gated channel alpha-3 (human) that has an Arg residue at the position equivalent to Gly-557 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Gly-557, CHEBI:29952." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000744

cyclic nucleotide-gated channel alpha-3 sequence variant V529M (human)

hCNGA3/var:V529M


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Met residue at the position equivalent to Val-529 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Val-529, CHEBI:16044." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000745

cyclic nucleotide-gated channel alpha-3 sequence variant R283W (human)

hCNGA3/var:R283W


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Trp residue at the position equivalent to Arg-283 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-283, CHEBI:29954." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000746

cyclic nucleotide-gated channel alpha-3 sequence variant F547L (human)

hCNGA3/var:F547L


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Leu residue at the position equivalent to Phe-547 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Phe-547, CHEBI:30006." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000747

cyclic nucleotide-gated channel alpha-3 sequence variant R410W (human)

hCNGA3/var:R410W


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Trp residue at the position equivalent to Arg-410 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-410, CHEBI:29954." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000748

cyclic nucleotide-gated channel alpha-3 sequence variant P163L (human)

hCNGA3/var:P163L


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Leu residue at the position equivalent to Pro-163 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Pro-163, CHEBI:30006." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q16281-1

cyclic nucleotide-gated channel alpha-3 isoform 1 (human)

hCNGA3/iso:1


"A cyclic nucleotide-gated channel alpha-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q16281-2

cyclic nucleotide-gated channel alpha-3 isoform h2 (human)

hCNGA3/iso:h2


"A cyclic nucleotide-gated channel alpha-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16281-2." [PRO:DNx, UniProtKB:Q16281]


organism-sequence



PR:Q16281-3

cyclic nucleotide-gated channel alpha-3 isoform h3 (human)

hCNGA3/iso:h3


"A cyclic nucleotide-gated channel alpha-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16281-3." [PRO:DNx, UniProtKB:Q16281]


organism-modification



PR:000081665

cyclic nucleotide-gated channel alpha-3 phosphorylated 1 (human)

hCNGA3/Phos:1


"A cyclic nucleotide-gated channel alpha-3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-341 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Ser-341, MOD:00046." [IEDB_epitope:2147051, PRO:DNx]


organism-gene



PR:Q90805

cyclic nucleotide-gated channel cone photoreceptor subunit alpha (chicken)

chick-CNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of chicken." [PRO:DAN]


organism-gene



PR:Q94A76

potassium channel GORK (Arabidopsis thaliana)

At-CNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]


organism-gene



PR:Q9ER33

cyclic nucleotide-gated channel alpha-3 (rat)

rCNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of rat." [OMA:Q9ER33, PRO:DNx]


organism-sequence



PR:Q9ER33-1

cyclic nucleotide-gated channel alpha-3 isoform r1 (rat)

rCNGA3/iso:r1


"A cyclic nucleotide-gated channel alpha-3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ER33-1." [PRO:DNx, UniProtKB:Q9ER33]


organism-sequence



PR:Q9ER33-2

cyclic nucleotide-gated channel alpha-3 isoform r2 (rat)

rCNGA3/iso:r2


"A cyclic nucleotide-gated channel alpha-3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ER33-2." [PRO:DNx, UniProtKB:Q9ER33]


organism-gene



PR:Q9JJZ8

cyclic nucleotide-gated channel alpha-3 (mouse)

mCNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of mouse." [OMA:Q9JJZ8, PRO:DNx]


organism-sequence



PR:Q9JJZ8-1

cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)

mCNGA3/iso:m1


"A cyclic nucleotide-gated channel alpha-3 isoform m1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9JJZ8]

Yes

sequence



PR:000000739

cyclic nucleotide-gated channel alpha-3 isoform 1

CNGA3/iso:1


"A cyclic nucleotide-gated channel alpha-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16281-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q16281-1

cyclic nucleotide-gated channel alpha-3 isoform 1 (human)

hCNGA3/iso:1


"A cyclic nucleotide-gated channel alpha-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000740

cyclic nucleotide-gated channel alpha-3 isoform m1

CNGA3/iso:m1


"A cyclic nucleotide-gated channel alpha-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJZ8-1 or a 1:1 ortholog thereof." [PMID:10813773, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9JJZ8-1

cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)

mCNGA3/iso:m1


"A cyclic nucleotide-gated channel alpha-3 isoform m1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9JJZ8]

Yes

gene



PR:000000698

cyclic nucleotide-gated channel alpha-2

CNGA2


"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q00195

cyclic nucleotide-gated channel alpha-2 (rat)

rCNGA2


"A cyclic nucleotide-gated channel alpha-2 that is encoded in the genome of rat." [OMA:Q00195, PRO:DNx]


organism-gene



PR:Q16280

cyclic nucleotide-gated channel alpha-2 (human)

hCNGA2


"A cyclic nucleotide-gated channel alpha-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q16280]


organism-gene



PR:Q62398

cyclic nucleotide-gated channel alpha-2 (mouse)

mCNGA2


"A cyclic nucleotide-gated channel alpha-2 that is encoded in the genome of mouse." [OMA:Q62398, PRO:DNx]

Yes

gene



PR:000005631

cyclic nucleotide-gated channel alpha-4

CNGA4


"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:Q3UW12

cyclic nucleotide-gated channel alpha-4 (mouse)

mCNGA4


"A cyclic nucleotide-gated channel alpha-4 that is encoded in the genome of mouse." [OMA:Q3UW12, PRO:DNx]


organism-sequence



PR:Q3UW12-1

cyclic nucleotide-gated channel alpha-4 isoform 1 (mouse)

mCNGA4/iso:1


"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q3UW12-2

cyclic nucleotide-gated channel alpha-4 isoform m2 (mouse)

mCNGA4/iso:m2


"A cyclic nucleotide-gated channel alpha-4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q3UW12-2." [PRO:DNx, UniProtKB:Q3UW12]


organism-gene



PR:Q64359

cyclic nucleotide-gated channel alpha-4 (rat)

rCNGA4


"A cyclic nucleotide-gated channel alpha-4 that is encoded in the genome of rat." [OMA:Q64359, PRO:DNx]


organism-sequence



PR:Q64359-1

cyclic nucleotide-gated channel alpha-4 isoform 1 (rat)

rCNGA4/iso:1


"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q8IV77

cyclic nucleotide-gated channel alpha-4 (human)

hCNGA4


"A cyclic nucleotide-gated channel alpha-4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8IV77]


organism-sequence



PR:Q8IV77-1

cyclic nucleotide-gated channel alpha-4 isoform 1 (human)

hCNGA4/iso:1


"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q8IV77-2

cyclic nucleotide-gated channel alpha-4 isoform h2 (human)

hCNGA4/iso:h2


"A cyclic nucleotide-gated channel alpha-4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IV77-2." [PRO:DNx, UniProtKB:Q8IV77]


sequence



PR:000041693

cyclic nucleotide-gated channel alpha-4 isoform 1

CNGA4/iso:1


"A cyclic nucleotide-gated channel alpha-4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8IV77-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:Q3UW12-1

cyclic nucleotide-gated channel alpha-4 isoform 1 (mouse)

mCNGA4/iso:1


"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q64359-1

cyclic nucleotide-gated channel alpha-4 isoform 1 (rat)

rCNGA4/iso:1


"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q8IV77-1

cyclic nucleotide-gated channel alpha-4 isoform 1 (human)

hCNGA4/iso:1


"A cyclic nucleotide-gated channel alpha-4 isoform 1 that is encoded in the genome of human." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000738 hCNGA1/var:S320F
Example: UniProtKB:P29973-1, Ser-320, CHEBI:29997
associated_with_disease_progressionDO:10584 retinitis pigmentosa PMID:7479749
located_inNOT GO:0005886 plasma membrane PMID:7479749
PR:000000741 hCNGA3/var:R283Q
Example: UniProtKB:Q16281-1, Arg-283, CHEBI:30011
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000742 hCNGA3/var:T291R
Example: UniProtKB:Q16281-1, Thr-291, CHEBI:29952
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000743 hCNGA3/var:G557R
Example: UniProtKB:Q16281-1, Gly-557, CHEBI:29952
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000744 hCNGA3/var:V529M
Example: UniProtKB:Q16281-1, Val-529, CHEBI:16044
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000745 hCNGA3/var:R283W
Example: UniProtKB:Q16281-1, Arg-283, CHEBI:29954
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000746 hCNGA3/var:F547L
Example: UniProtKB:Q16281-1, Phe-547, CHEBI:30006
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000747 hCNGA3/var:R410W
Example: UniProtKB:Q16281-1, Arg-410, CHEBI:29954
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000748 hCNGA3/var:P163L
Example: UniProtKB:Q16281-1, Pro-163, CHEBI:30006
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000036569 cow-CNGA1/iso:1/Phos:1
UniProtKB:Q00194-1, Tyr-498, MOD:00048
enablesdecreased GO:0030553 cGMP binding relative to PR:000002593 PMID:10366613
PR:000045381 cow-CNGA1/iso:1/UnPhos:1
UniProtKB:Q00194-1, Tyr-498, PR:000026291
enablesGO:0030553 cGMP binding PMID:10366613
PR:P29973-1 hCNGA1/iso:1 located_inGO:0005886 plasma membrane PMID:7479749
PR:P29974 mCNGA1 located_inGO:0001750 photoreceptor outer segment PMID:15634774
PR:Q00194-1 cow-CNGA1/iso:1 located_inGO:0017071 intracellular cyclic nucleotide activated cation channel complex PMID:12432397; PMID:12467591
PR:Q16281-1 hCNGA3/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9517456
enablesGO:0015276 ligand-gated monoatomic ion channel activity PMID:9517456
located_inGO:0017071 intracellular cyclic nucleotide activated cation channel complex PMID:12467591
PR:Q62398 mCNGA2 acts_upstream_of_or_withinGO:0007608 sensory perception of smell PMID:10798394
enablesGO:0005216 monoatomic ion channel activity PMID:10798394
PR:Q9JJZ8-1 mCNGA3/iso:m1 enablescontributes_to GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity PMID:10662822
located_inGO:0001750 photoreceptor outer segment PMID:10813773; PMID:15634774
GO:0032991 protein-containing complex PMID:10662822