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Protein Ontology report - cyclic nucleotide-gated channel beta subunit
PR:000000674 - http://purl.obolibrary.org/obo/PR_000000674
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000674   
  PRO namecyclic nucleotide-gated channel beta subunit 
  Definition"A cyclic nucleotide-regulated channel protein that is the modulatory subunit of the cyclic nucleotide-gated channel (CNG channel). It consists of amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The carboxy-terminal region contains the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) and a region connecting the CNBD to the S6 segment (C-linker), which is important for modulation by transition metals. CNG beta subunits combine with the alpha subunits to form the cyclic nucleotide-gated ion channels, which mediate sensory transduction in photoreceptors and olfactory sensory neurons. These channels are likely composed of four subunits around a centrally located ion-permeable pore that opens in response to the direct binding of intracellular cyclic nucleotides. CNG channels are non-selective cation channels. They are not gated by membrane voltage although their structure includes the transmembrane S4 motif known to function as the membrane voltage sensor in all voltage-gated ion channels, but it has been shown to be important for proper folding and processing. Alpha and beta subunits of the CNG channel are very similar, however the beta subunits are not able to form functional channels by themselves." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000044648 cyclic nucleotide-regulated channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 4                                        
         Sequence3                                                  Organism-Sequence 8                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038515
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000674 cyclic nucleotide-gated channel beta subunit
CATSPERB

gene


PR:000000697 cyclic nucleotide-gated channel beta-3
CNGB3

organism-gene


PR:Q9JJZ9 cyclic nucleotide-gated channel beta-3 (mouse)
mCNGB3

organism-sequence


PR:Q9JJZ9-1 cyclic nucleotide-gated channel beta-3 isoform 1 (mouse)
mCNGB3/iso:1
Yes
organism-gene


PR:Q9NQW8 cyclic nucleotide-gated channel beta-3 (human)
hCNGB3

organism-sequence


PR:000000752 cyclic nucleotide-gated channel beta-3 sequence variant S435F (human)
hCNGB3/var:S435F
Yes
organism-sequence


PR:Q9NQW8-1 cyclic nucleotide-gated channel beta-3 isoform 1 (human)
hCNGB3/iso:1

organism-sequence


PR:Q9NQW8-2 cyclic nucleotide-gated channel beta-3 isoform 2 (human)
hCNGB3/iso:2

sequence


PR:000000749 cyclic nucleotide-gated channel beta-3 isoform 1
CNGB3/iso:1

organism-sequence


PR:Q9JJZ9-1 cyclic nucleotide-gated channel beta-3 isoform 1 (mouse)
mCNGB3/iso:1
Yes
sequence


PR:000000750 cyclic nucleotide-gated channel beta-3 isoform 2
CNGB3/iso:2

organism-sequence


PR:Q9NQW8-2 cyclic nucleotide-gated channel beta-3 isoform 2 (human)
hCNGB3/iso:2

sequence


PR:000000751 cyclic nucleotide-gated channel beta-3 isoform 3
CNGB3/iso:3

organism-sequence


PR:Q9NQW8-1 cyclic nucleotide-gated channel beta-3 isoform 1 (human)
hCNGB3/iso:1

gene


PR:000005632 cyclic nucleotide-gated channel beta-1
CNGB1

organism-gene


PR:Q14028 cyclic nucleotide-gated channel beta-1 (human)
hCNGB1

organism-sequence


PR:Q14028-1 cyclic nucleotide-gated channel beta-1 isoform hRCNC2B (human)
hCNGB1/iso:hRCNC2B

organism-sequence


PR:Q14028-2 cyclic nucleotide-gated channel beta-1 isoform hRCNC2A (human)
hCNGB1/iso:hRCNC2A

organism-sequence


PR:Q14028-3 cyclic nucleotide-gated channel beta-1 isoform hGARP2 (human)
hCNGB1/iso:hGARP2

organism-sequence


PR:Q14028-4 cyclic nucleotide-gated channel beta-1 isoform h4 (human)
hCNGB1/iso:h4

organism-modification


PR:000065272 cyclic nucleotide-gated channel beta-1 deaminated 1 (human)
hCNGB1/Deam:1

organism-modification


PR:000068737 cyclic nucleotide-gated channel beta-1 phosphorylated 1 (human)
hCNGB1/Phos:1

organism-modification


PR:000071055 cyclic nucleotide-gated channel beta-1 phosphorylated 2 (human)
hCNGB1/Phos:2

organism-gene


PR:Q39128 potassium channel KAT1 (Arabidopsis thaliana)
At-CNGB1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000752 hCNGB3/var:S435F
Example: UniProtKB:Q9NQW8-1, Ser-435, CHEBI:29997		 associated_with_disease_progressionDO:13911 achromatopsia PMID:10888875; PMID:10958649
PR:Q9JJZ9-1 mCNGB3/iso:1 enablesGO:0005223 intracellularly cGMP-activated cation channel activity PMID:10662822
GO:0005515 protein binding PMID:10662822
located_inGO:0001750 photoreceptor outer segment PMID:15634774
GO:0005886 plasma membrane PMID:10662822