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family
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PR:000000676 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
|
CATSPERB
|
"A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The N terminus has a conserved domain that is also present in other voltage-gated potassium and sodium channels. The carboxyl-terminal region contains the cyclic nucleotide-binding domain (CNBD). In addition, there is a structural element called the C-linker, the region connecting the CNBD to the S6 segment, which couples conformational changes in the ligand-binding domain to channel activation. Subunits combine to form the HCN channels. In common with CNG channels, HCN are cation channels that are modulated by cyclic nucleotide binding. Unlike CNG channels, HCN channels are voltage-gated, and are weakly selective for potassium. In contrast to most other voltage-gated channels, HCN channels open upon hyperpolarization and close at positive potential. HCN channels act as a pacemaker by regulating neuronal and cardiac firing rate, but also function as a regulator of membrane resting potential and resistance." [PMID:16382102]
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gene
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PR:000000705 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
|
HCN1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN1 gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:O60741 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (human)
|
hHCN1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O60741]
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organism-gene
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PR:O88704 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (mouse)
|
mHCN1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of mouse." [OMA:O88704, PRO:DNx]
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organism-sequence
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PR:O88704-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 (mouse)
|
mHCN1/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
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organism-modification
|
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PR:000036573 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse)
|
mHCN1/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88704-1, Asn-327, MOD:00160." [PMID:12928435, PRO:CNA, PRO:DAN]
|
Yes |
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organism-gene
|
|
PR:Q9JKB0 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (rat)
|
rHCN1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is encoded in the genome of rat." [OMA:Q9JKB0, PRO:DNx]
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sequence
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PR:000000755 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1
|
HCN1/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88704-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:O88704-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 (mouse)
|
mHCN1/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
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organism-modification
|
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PR:000036573 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse)
|
mHCN1/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88704-1, Asn-327, MOD:00160." [PMID:12928435, PRO:CNA, PRO:DAN]
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Yes |
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| | |
modification
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PR:000000935 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 glycosylated form
|
HCN1/iso:1/GlycoRes+
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 that includes at least one glycosylated residue." [PRO:CNA]
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modification
|
|
PR:000000984 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1
|
HCN1/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 glycosylated form with N-glycosylation at the N-linked glycosylation consensus sequence (Nx[ST]) in the extracellular domain between S5 and S6 transmembrane segments. Example: UniProtKB:O88704-1, Asn-327, MOD:00160." [PMID:17988239]
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organism-modification
|
|
PR:000036573 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse)
|
mHCN1/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88704-1, Asn-327, MOD:00160." [PMID:12928435, PRO:CNA, PRO:DAN]
|
Yes |
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gene
|
|
PR:000000706 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
|
HCN2
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN2 gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:O88703 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse)
|
mHCN2
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of mouse." [OMA:O88703, PRO:DNx]
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organism-sequence
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|
PR:O88703-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)
|
mHCN2/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
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|
organism-modification
|
|
PR:000036574 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
|
mHCN2/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]
|
Yes |
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| | |
organism-modification
|
|
PR:000046119 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 phosphorylated 1 (mouse)
|
mHCN2/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse) that has been phosphorylated at Ser-641. UniProtKB:O88703, Ser-641, MOD:00046." [iPTMnet:O88703, PMID:21347269]
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organism-modification
|
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PR:000084040 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 deaminated 1 (mouse)
|
mHCN2/Deam:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse) that has been deaminated on the residue at the position equivalent to Gln-694 of the amino acid sequence represented by UniProtKB:O88703. UniProtKB:O88703, Gln-694, MOD:00685." [IEDB_epitope:2136599, PRO:DNx]
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organism-gene
|
|
PR:Q9JKA9 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (rat)
|
rHCN2
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of rat." [OMA:Q9JKA9, PRO:DNx]
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organism-gene
|
|
PR:Q9UL51 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (human)
|
hHCN2
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UL51]
|
Yes |
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sequence
|
|
PR:000000756 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1
|
HCN2/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88703-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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| | |
organism-sequence
|
|
PR:O88703-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)
|
mHCN2/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
Yes |
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|
| | | | | | | | | | |
|
organism-modification
|
|
PR:000036574 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
|
mHCN2/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]
|
Yes |
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|
| | | | | | | | |
| | |
modification
|
|
PR:000000936 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form
|
HCN2/iso:1/GlycoRes+
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that includes at least one glycosylated residue." [PRO:CNA]
|
|
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| | | | | | | | | | |
|
modification
|
|
PR:000000985 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1
|
HCN2/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form with N-glycosylation at the N-linked glycosylation consensus sequence (Nx[ST]) in the extracellular domain between S5 and S6 transmembrane segments. Example: UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435]
|
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organism-modification
|
|
PR:000036574 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
|
mHCN2/iso:1/NGlyco:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]
|
Yes |
|
|
|
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|
| | | | |
| | | | | | |
gene
|
|
PR:000000707 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
|
HCN3
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN3 gene or a 1:1 ortholog thereof." [PRO:CNA]
|
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organism-gene
|
|
PR:G5EFJ9 |
potassium voltage-gated channel unc-103 (worm)
|
HCN3 (worm)
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of worm." [OMA:G5EFJ9, PRO:DNx]
|
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| | |
organism-sequence
|
|
PR:G5EFJ9-1 |
potassium voltage-gated channel unc-103 isoform a (worm)
|
HCN3/iso:a (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-1." [PRO:DNx, UniProtKB:G5EFJ9]
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| | |
organism-sequence
|
|
PR:G5EFJ9-10 |
potassium voltage-gated channel unc-103 isoform j (worm)
|
HCN3/iso:j (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-10." [PRO:DNx, UniProtKB:G5EFJ9]
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| | |
organism-sequence
|
|
PR:G5EFJ9-2 |
potassium voltage-gated channel unc-103 isoform c (worm)
|
HCN3/iso:c (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-2." [PRO:DNx, UniProtKB:G5EFJ9]
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| | |
organism-sequence
|
|
PR:G5EFJ9-3 |
potassium voltage-gated channel unc-103 isoform b (worm)
|
HCN3/iso:b (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-3." [PRO:DNx, UniProtKB:G5EFJ9]
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| | |
organism-sequence
|
|
PR:G5EFJ9-4 |
potassium voltage-gated channel unc-103 isoform h (worm)
|
HCN3/iso:h (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-4." [PRO:DNx, UniProtKB:G5EFJ9]
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| | |
organism-sequence
|
|
PR:G5EFJ9-5 |
potassium voltage-gated channel unc-103 isoform e (worm)
|
HCN3/iso:e (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-5." [PRO:DNx, UniProtKB:G5EFJ9]
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| | |
organism-sequence
|
|
PR:G5EFJ9-6 |
potassium voltage-gated channel unc-103 isoform d (worm)
|
HCN3/iso:d (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-6." [PRO:DNx, UniProtKB:G5EFJ9]
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| | |
organism-sequence
|
|
PR:G5EFJ9-7 |
potassium voltage-gated channel unc-103 isoform g (worm)
|
HCN3/iso:g (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-7." [PRO:DNx, UniProtKB:G5EFJ9]
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| | |
organism-sequence
|
|
PR:G5EFJ9-8 |
potassium voltage-gated channel unc-103 isoform f (worm)
|
HCN3/iso:f (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-8." [PRO:DNx, UniProtKB:G5EFJ9]
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| | |
organism-sequence
|
|
PR:G5EFJ9-9 |
potassium voltage-gated channel unc-103 isoform i (worm)
|
HCN3/iso:i (worm)
|
"A potassium voltage-gated channel unc-103 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:G5EFJ9-9." [PRO:DNx, UniProtKB:G5EFJ9]
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| | | | |
organism-gene
|
|
PR:O88705 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (mouse)
|
mHCN3
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of mouse." [OMA:O88705, PRO:DNx]
|
|
|
|
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| | | | | | | | |
| | |
organism-sequence
|
|
PR:O88705-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 (mouse)
|
mHCN3/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-modification
|
|
PR:000029934 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 (mouse)
|
mHCN3/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 in mouse. UniProtKB:O88705, Ser-633, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
|
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|
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|
| | | | | | |
| | | | |
organism-gene
|
|
PR:Q9JKA8 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (rat)
|
rHCN3
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of rat." [OMA:Q9JKA8, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
organism-gene
|
|
PR:Q9P1Z3 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (human)
|
hHCN3
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9P1Z3]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
sequence
|
|
PR:000000757 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1
|
HCN3/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88705-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-sequence
|
|
PR:O88705-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 (mouse)
|
mHCN3/iso:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
modification
|
|
PR:000029933 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1
|
HCN3/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 that has been phosphorylated on the residue at the position equivalent to Ser-633 of the amino acid sequence represented by UniProtKB:O88705. Example: UniProtKB:O88705, Ser-633, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-modification
|
|
PR:000029934 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 (mouse)
|
mHCN3/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 in mouse. UniProtKB:O88705, Ser-633, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
|
|
|
|
|
| | | | |
| | | | | | |
gene
|
|
PR:000000708 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
|
HCN4
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN4 gene or a 1:1 ortholog thereof." [PRO:CNA]
|
|
|
|
|
|
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| | | | |
organism-gene
|
|
PR:O70507 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (mouse)
|
mHCN4
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of mouse." [OMA:O70507, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | | | |
| | |
organism-modification
|
|
PR:000029936 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse)
|
mHCN4/Phos:1
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 in mouse. UniProtKB:O70507, Ser-921, MOD:00046." [PMID:17114649, PRO:HJD]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
organism-gene
|
|
PR:Q9JKA7 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rat)
|
rHCN4
|
"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of rat." [OMA:Q9JKA7, PRO:DNx]
|
|
|
|
|
|
|
| | | | | | |
| | | | |
organism-gene
|
|
PR:Q9TV66 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit)
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rabbit-HCN4
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of rabbit." [PRO:DAN]
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organism-sequence
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PR:Q9TV66-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform r1 (rabbit)
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rabbit-HCN4/iso:r1
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9TV66-1." [PRO:DAN]
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Yes |
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organism-gene
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PR:Q9Y3Q4 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human)
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hHCN4
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9Y3Q4]
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organism-sequence
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PR:000000759 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human)
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hHCN4/var:D553N
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) that has an Asn residue at the position equivalent to Asp-553 of the amino acid sequence represented by UniProtKB:Q9Y3Q4. UniProtKB:Q9Y3Q4, Asp-553, CHEBI:50347." [PMID:15123648, PRO:CNA, PRO:DAN]
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Yes |
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organism-sequence
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PR:000000760 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human)
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hHCN4/var:S672R
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human) that has an Arg residue at the position equivalent to Ser-672 of the amino acid sequence represented by UniProtKB:Q9Y3Q4. UniProtKB:Q9Y3Q4, Ser-672, CHEBI:29952." [PMID:16407510, PRO:CNA, PRO:DAN]
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Yes |
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organism-sequence
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PR:Q9Y3Q4-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human)
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hHCN4/iso:1
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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sequence
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PR:000000758 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1
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HCN4/iso:1
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y3Q4-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:Q9Y3Q4-1 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human)
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hHCN4/iso:1
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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modification
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PR:000002604 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 unmodified form
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HCN4/iso:1/UnMod
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]
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modification
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PR:000029935 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1
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HCN4/Phos:1
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 that has been phosphorylated on the residue at the position equivalent to Ser-921 of the amino acid sequence represented by UniProtKB:O70507. Example: UniProtKB:O70507, Ser-921, MOD:00046." [PMID:17114649, PRO:HJD]
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organism-modification
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PR:000029936 |
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse)
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mHCN4/Phos:1
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"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 in mouse. UniProtKB:O70507, Ser-921, MOD:00046." [PMID:17114649, PRO:HJD]
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