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Protein Ontology report - potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
PR:000000676 - http://purl.obolibrary.org/obo/PR_000000676
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000676   
  PRO namepotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein 
  Synonyms
Other: EXACT:f-channel
RELATED:HCN
  Definition"A cyclic nucleotide-regulated channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The N terminus has a conserved domain that is also present in other voltage-gated potassium and sodium channels. The carboxyl-terminal region contains the cyclic nucleotide-binding domain (CNBD). In addition, there is a structural element called the C-linker, the region connecting the CNBD to the S6 segment, which couples conformational changes in the ligand-binding domain to channel activation. Subunits combine to form the HCN channels. In common with CNG channels, HCN are cation channels that are modulated by cyclic nucleotide binding. Unlike CNG channels, HCN channels are voltage-gated, and are weakly selective for potassium. In contrast to most other voltage-gated channels, HCN channels open upon hyperpolarization and close at positive potential. HCN channels act as a pacemaker by regulating neuronal and cardiac firing rate, but also function as a regulator of membrane resting potential and resistance." [PMID:16382102] 
  PRO Categoryfamily 
  ParentPR:000044648 cyclic nucleotide-regulated channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 14                                        
         Sequence4                                                  Organism-Sequence 17                                        
         Modification7                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038514
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000676 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
CATSPERB

gene


PR:000000705 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
HCN1

organism-gene


PR:O60741 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (human)
hHCN1

organism-gene


PR:O88704 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (mouse)
mHCN1

organism-sequence


PR:O88704-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 (mouse)
mHCN1/iso:1
Yes
organism-modification


PR:000036573 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse)
mHCN1/iso:1/NGlyco:1
Yes
organism-gene


PR:Q9JKB0 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (rat)
rHCN1

sequence


PR:000000755 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1
HCN1/iso:1

organism-sequence


PR:O88704-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 (mouse)
mHCN1/iso:1
Yes
organism-modification


PR:000036573 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse)
mHCN1/iso:1/NGlyco:1
Yes
modification


PR:000000935 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 glycosylated form
HCN1/iso:1/GlycoRes+

modification


PR:000000984 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1
HCN1/iso:1/NGlyco:1

organism-modification


PR:000036573 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 isoform 1 N-glycosylated 1 (mouse)
mHCN1/iso:1/NGlyco:1
Yes
gene


PR:000000706 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
HCN2

organism-gene


PR:O88703 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse)
mHCN2

organism-sequence


PR:O88703-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)
mHCN2/iso:1
Yes
organism-modification


PR:000036574 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
mHCN2/iso:1/NGlyco:1
Yes
organism-modification


PR:000046119 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 phosphorylated 1 (mouse)
mHCN2/Phos:1

organism-modification


PR:000084040 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 deaminated 1 (mouse)
mHCN2/Deam:1

organism-gene


PR:Q9JKA9 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (rat)
rHCN2

organism-gene


PR:Q9UL51 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (human)
hHCN2
Yes
sequence


PR:000000756 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1
HCN2/iso:1

organism-sequence


PR:O88703-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)
mHCN2/iso:1
Yes
organism-modification


PR:000036574 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
mHCN2/iso:1/NGlyco:1
Yes
modification


PR:000000936 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form
HCN2/iso:1/GlycoRes+

modification


PR:000000985 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1
HCN2/iso:1/NGlyco:1

organism-modification


PR:000036574 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
mHCN2/iso:1/NGlyco:1
Yes
gene


PR:000000707 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
HCN3

organism-gene


PR:G5EFJ9 potassium voltage-gated channel unc-103 (worm)
HCN3 (worm)

organism-sequence


PR:G5EFJ9-1 potassium voltage-gated channel unc-103 isoform a (worm)
HCN3/iso:a (worm)

organism-sequence


PR:G5EFJ9-10 potassium voltage-gated channel unc-103 isoform j (worm)
HCN3/iso:j (worm)

organism-sequence


PR:G5EFJ9-2 potassium voltage-gated channel unc-103 isoform c (worm)
HCN3/iso:c (worm)

organism-sequence


PR:G5EFJ9-3 potassium voltage-gated channel unc-103 isoform b (worm)
HCN3/iso:b (worm)

organism-sequence


PR:G5EFJ9-4 potassium voltage-gated channel unc-103 isoform h (worm)
HCN3/iso:h (worm)

organism-sequence


PR:G5EFJ9-5 potassium voltage-gated channel unc-103 isoform e (worm)
HCN3/iso:e (worm)

organism-sequence


PR:G5EFJ9-6 potassium voltage-gated channel unc-103 isoform d (worm)
HCN3/iso:d (worm)

organism-sequence


PR:G5EFJ9-7 potassium voltage-gated channel unc-103 isoform g (worm)
HCN3/iso:g (worm)

organism-sequence


PR:G5EFJ9-8 potassium voltage-gated channel unc-103 isoform f (worm)
HCN3/iso:f (worm)

organism-sequence


PR:G5EFJ9-9 potassium voltage-gated channel unc-103 isoform i (worm)
HCN3/iso:i (worm)

organism-gene


PR:O88705 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (mouse)
mHCN3

organism-sequence


PR:O88705-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 (mouse)
mHCN3/iso:1

organism-modification


PR:000029934 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 (mouse)
mHCN3/Phos:1

organism-gene


PR:Q9JKA8 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (rat)
rHCN3

organism-gene


PR:Q9P1Z3 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (human)
hHCN3

sequence


PR:000000757 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1
HCN3/iso:1

organism-sequence


PR:O88705-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform 1 (mouse)
mHCN3/iso:1

modification


PR:000029933 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1
HCN3/Phos:1

organism-modification


PR:000029934 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 phosphorylated 1 (mouse)
mHCN3/Phos:1

gene


PR:000000708 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
HCN4

organism-gene


PR:O70507 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (mouse)
mHCN4

organism-modification


PR:000029936 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse)
mHCN4/Phos:1

organism-gene


PR:Q9JKA7 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rat)
rHCN4

organism-gene


PR:Q9TV66 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (rabbit)
rabbit-HCN4

organism-sequence


PR:Q9TV66-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform r1 (rabbit)
rabbit-HCN4/iso:r1
Yes
organism-gene


PR:Q9Y3Q4 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (human)
hHCN4

organism-sequence


PR:000000759 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant D553N (human)
hHCN4/var:D553N
Yes
organism-sequence


PR:000000760 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 sequence variant S672R (human)
hHCN4/var:S672R
Yes
organism-sequence


PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human)
hHCN4/iso:1
Yes
sequence


PR:000000758 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1
HCN4/iso:1

organism-sequence


PR:Q9Y3Q4-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 (human)
hHCN4/iso:1
Yes
modification


PR:000002604 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 isoform 1 unmodified form
HCN4/iso:1/UnMod

modification


PR:000029935 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1
HCN4/Phos:1

organism-modification


PR:000029936 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 phosphorylated 1 (mouse)
mHCN4/Phos:1

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006812 monoatomic cation transportPR:O88704-1 mHCN1/iso:1 PMID:9630217
PR:Q9UL51 hHCN2 PMID:10228147
PR:Q9Y3Q4-1 hHCN4/iso:1 PMID:10228147
GO:0006936 muscle contractionPR:Q9UL51 hHCN2 PMID:10228147
PR:Q9Y3Q4-1 hHCN4/iso:1 PMID:10228147
GO:0007267 cell-cell signalingPR:Q9UL51 hHCN2 PMID:9630217

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:13884 sick sinus syndromePR:000000759 hHCN4/var:D553N PMID:15123648
PR:000000760 hHCN4/var:S672R PMID:16407510

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005222 intracellularly cAMP-activated cation channel activityPR:000000760 hHCN4/var:S672R PMID:16407510
contributes_to GO:0005222 intracellularly cAMP-activated cation channel activityPR:O88703-1 mHCN2/iso:1 PMID:11459060
PR:O88704-1 mHCN1/iso:1 PMID:11459060; PMID:9630217
GO:0005261 monoatomic cation channel activityPR:O88704-1 mHCN1/iso:1 PMID:9630217
PR:Q9UL51 hHCN2 PMID:10228147
PR:Q9Y3Q4-1 hHCN4/iso:1 PMID:10228147
GO:0022843 voltage-gated monoatomic cation channel activityPR:000000760 hHCN4/var:S672R PMID:16407510
PR:O88704-1 mHCN1/iso:1 PMID:9634236

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:Q9TV66-1 rabbit-HCN4/iso:r1 PMID:15123648
NOT GO:0005886 plasma membranePR:000000759 hHCN4/var:D553N PMID:15123648
GO:0009986 cell surfacePR:000036573 mHCN1/iso:1/NGlyco:1 PMID:12928435
PR:000036574 mHCN2/iso:1/NGlyco:1 PMID:12928435
PR:O88703-1 mHCN2/iso:1 PMID:12034718; PMID:15564593
PR:O88704-1 mHCN1/iso:1 PMID:15564593
GO:0030424 axonPR:O88704-1 mHCN1/iso:1 PMID:15479642
GO:0032991 protein-containing complexPR:O88703-1 mHCN2/iso:1 PMID:12034718
PR:O88704-1 mHCN1/iso:1 PMID:12034718