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Protein Ontology report - shab-related voltage-gated potassium channel alpha subunit
PR:000000677 - http://purl.obolibrary.org/obo/PR_000000677
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000677   
  PRO nameshab-related voltage-gated potassium channel alpha subunit 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_shab_sub-a
Other: RELATED:Kv2 channel
  Definition"A voltage-gated potassium channel protein that has a conserved carboxyl-terminal domain called the Kv2 channel domain. Kv2 channels are known as delayed rectifier channels. Shab-related voltage-potassium channels are involved in maintaining membrane potential and modulating electrical excitability in neurons. In common with other voltage-gated channels, has a domain composition consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. The charged S4 segment with a basic amino acid at every third position confers their voltage sensitivity. In common with Kv3 and Kv4 channels, the tetramerization domain at the N terminus contains a zinc binding site." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000044654 voltage-gated potassium channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038520
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000677

shab-related voltage-gated potassium channel alpha subunit

fam:Kchan_shab_sub-a


"A voltage-gated potassium channel protein that has a conserved carboxyl-terminal domain called the Kv2 channel domain. Kv2 channels are known as delayed rectifier channels. Shab-related voltage-potassium channels are involved in maintaining membrane potential and modulating electrical excitability in neurons. In common with other voltage-gated channels, has a domain composition consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. The charged S4 segment with a basic amino acid at every third position confers their voltage sensitivity. In common with Kv3 and Kv4 channels, the tetramerization domain at the N terminus contains a zinc binding site." [PRO:CNA]


gene



PR:000000722

voltage-gated potassium channel KCNB1

KCNB1


"A shab-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNB1 gene or a 1:1 ortholog thereof. It associates with other subunits to generate a delayed rectifier potassium channel." [PRO:CNA]


organism-gene



PR:P15387

potassium voltage-gated channel subfamily B member 1 (rat)

rKCNB1


"A voltage-gated potassium channel KCNB1 that is encoded in the genome of rat." [OMA:P15387, PRO:DNx]


organism-gene



PR:Q03717

potassium voltage-gated channel subfamily B member 1 (mouse)

mKCNB1


"A voltage-gated potassium channel KCNB1 that is encoded in the genome of mouse." [OMA:Q03717, PRO:DNx]


organism-sequence



PR:Q03717-1

potassium voltage-gated channel subfamily B member 1 isoform 1 (mouse)

mKCNB1/iso:1


"A voltage-gated potassium channel KCNB1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q14721

potassium voltage-gated channel subfamily B member 1 (human)

hKCNB1


"A voltage-gated potassium channel KCNB1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q14721]


organism-sequence



PR:Q14721-1

potassium voltage-gated channel subfamily B member 1 isoform 1 (human)

hKCNB1/iso:1


"A voltage-gated potassium channel KCNB1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000779

voltage-gated potassium channel KCNB1 isoform 1

KCNB1/iso:1


"A voltage-gated potassium channel KCNB1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q14721-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q03717-1

potassium voltage-gated channel subfamily B member 1 isoform 1 (mouse)

mKCNB1/iso:1


"A voltage-gated potassium channel KCNB1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q14721-1

potassium voltage-gated channel subfamily B member 1 isoform 1 (human)

hKCNB1/iso:1


"A voltage-gated potassium channel KCNB1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000000723

voltage-gated potassium channel KCNB2

KCNB2


"A shab-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNB2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:A6H8H5

potassium voltage-gated channel subfamily B member 2 (mouse)

mKCNB2


"A voltage-gated potassium channel KCNB2 that is encoded in the genome of mouse." [OMA:A6H8H5, PRO:DNx]


organism-gene



PR:Q63099

potassium voltage-gated channel subfamily B member 2 (rat)

rKCNB2


"A voltage-gated potassium channel KCNB2 that is encoded in the genome of rat." [OMA:Q63099, PRO:DNx]


organism-gene



PR:Q92953

potassium voltage-gated channel subfamily B member 2 (human)

hKCNB2


"A voltage-gated potassium channel KCNB2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q92953]


organism-sequence



PR:Q92953-1

potassium voltage-gated channel subfamily B member 2 isoform 1 (human)

hKCNB2/iso:1


"A voltage-gated potassium channel KCNB2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000085101

potassium voltage-gated channel subfamily B member 2 cysteinylated 1 (human)

hKCNB2/Cyst:1


"A potassium voltage-gated channel subfamily B member 2 (human) that has been cysteinylated on the residue at the position equivalent to Cys-883 of the amino acid sequence represented by UniProtKB:Q92953. UniProtKB:Q92953, Cys-883, MOD:00765." [IEDB_epitope:883759, PRO:DNx]


sequence



PR:000000780

voltage-gated potassium channel KCNB2 isoform 1

KCNB2/iso:1


"A voltage-gated potassium channel KCNB2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92953-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q92953-1

potassium voltage-gated channel subfamily B member 2 isoform 1 (human)

hKCNB2/iso:1


"A voltage-gated potassium channel KCNB2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q92953-1 hKCNB2/iso:1 acts_upstream_of_or_withinGO:0006940 regulation of smooth muscle contraction PMID:9612272
enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9612272