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Protein Ontology report - sodium leak channel NALCN
PR:000000678 - http://purl.obolibrary.org/obo/PR_000000678
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000678   
  PRO namesodium leak channel NALCN 
  Synonyms
PRO-Short-label: EXACT:NALCN
Gene-based: RELATED:VGCNL1
Other: EXACT:CanIon | sodium leak channel non-selective protein | voltage gated channel-like protein 1
  Definition"An ion channel protein that is a translation product of the human NALCN gene or a 1:1 ortholog thereof. The prototype subunit contains four copies of the six transmembrane ion transport protein domain, but the number of copies of this domain varies among splice variants. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. They are subunits of a voltage-independent, nonselective cation channel." [PMID:17448995, PRO:CNA] 
  CommentNote: NALCN operates as part of a complex with UNC80 (PR:000017098) and UNC79 (PR:000030850) that together form a fucntional channel. [PRO:DAN, PMID:21040849]. 
  PRO Categorygene 
  ParentPR:000049983 ion channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 5                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038547;IUPHARobj:750
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000678 sodium leak channel NALCN
NALCN
Yes
organism-gene


PR:Q6Q760 sodium leak channel NALCN (rat)
rNALCN

organism-gene


PR:Q8BXR5 sodium leak channel NALCN (mouse)
mNALCN

organism-sequence


PR:Q8BXR5-1 sodium leak channel NALCN isoform 1 (mouse)
mNALCN/iso:1

organism-sequence


PR:Q8BXR5-2 sodium leak channel NALCN isoform 2 (mouse)
mNALCN/iso:2

organism-gene


PR:Q8IZF0 sodium leak channel NALCN (human)
hNALCN

organism-sequence


PR:Q8IZF0-1 sodium leak channel NALCN isoform 1 (human)
hNALCN/iso:1

organism-sequence


PR:Q8IZF0-2 sodium leak channel NALCN isoform 2 (human)
hNALCN/iso:2

organism-sequence


PR:Q8IZF0-3 sodium leak channel NALCN isoform 3 (human)
hNALCN/iso:3

organism-modification


PR:000066671 sodium leak channel NALCN deaminated 1 (human)
hNALCN/Deam:1

organism-modification


PR:000083319 sodium leak channel NALCN phosphorylated 1 (human)
hNALCN/Phos:1

sequence


PR:000000715 sodium leak channel NALCN isoform 1
NALCN/iso:1

organism-sequence


PR:Q8BXR5-1 sodium leak channel NALCN isoform 1 (mouse)
mNALCN/iso:1

organism-sequence


PR:Q8IZF0-1 sodium leak channel NALCN isoform 1 (human)
hNALCN/iso:1

sequence


PR:000000716 sodium leak channel NALCN isoform 2
NALCN/iso:2

organism-sequence


PR:Q8IZF0-2 sodium leak channel NALCN isoform 2 (human)
hNALCN/iso:2

sequence


PR:000000717 sodium leak channel NALCN isoform 3
NALCN/iso:3

organism-sequence


PR:Q8BXR5-2 sodium leak channel NALCN isoform 2 (mouse)
mNALCN/iso:2

organism-sequence


PR:Q8IZF0-3 sodium leak channel NALCN isoform 3 (human)
hNALCN/iso:3

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000678 NALCN
They are subunits of a voltage-independent, nonselective cation channel		 acts_upstream_of_or_withinGO:0006811 monoatomic ion transport PIRSF:PIRSF038547
enablescontributes_to GO:0005216 monoatomic ion channel activity PIRSF:PIRSF038547