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Protein Ontology report - transient receptor potential cation channel TRPA
PR:000000679 -
http://purl.obolibrary.org/obo/PR_000000679
Protein Forms
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000679
PRO name
transient receptor potential cation channel TRPA
Synonyms
PRO-Short-label
:
EXACT:
fam:TRPA
Definition
"A transient receptor potential channel protein that is a member of the subfamily A of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains 14-16 copies of Ankyrin repeat (
Pfam:PF00023
). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means." [
PMID:16382100
,
PMID:16460286
,
PMID:17579562
, PRO:WCB]
PRO Category
family
Parent
PR:000044657
transient receptor potential channel protein
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Family
1
Organism-Family
0
Gene
1
Organism-Gene
4
Sequence
1
Organism-Sequence
4
Modification
0
Organism-Modification
2
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF038535
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
Comp.
In Complex?
family
PR:000000679
transient receptor potential cation channel TRPA
fam:TRPA
gene
PR:000000699
transient receptor potential cation channel TRPA1
TRPA1
organism-gene
PR:O75762
transient receptor potential cation channel subfamily A member 1 (human)
hTRPA1
organism-sequence
PR:O75762-1
transient receptor potential cation channel subfamily A member 1 isoform 1 (human)
hTRPA1/iso:1
organism-modification
PR:000075852
transient receptor potential cation channel subfamily A member 1 deaminated 1 (human)
hTRPA1/Deam:1
organism-modification
PR:000079624
transient receptor potential cation channel subfamily A member 1 methylated 1 (human)
hTRPA1/Me:1
organism-gene
PR:Q6RI86
transient receptor potential cation channel subfamily A member 1 (rat)
rTRPA1
organism-gene
PR:Q8BLA8
transient receptor potential cation channel subfamily A member 1 (mouse)
mTRPA1
Yes
organism-sequence
PR:Q8BLA8-1
transient receptor potential cation channel subfamily A member 1 isoform 1 (mouse)
mTRPA1/iso:1
Yes
sequence
PR:000001059
transient receptor potential cation channel TRPA1 isoform 1
TRPA1/iso:1
organism-sequence
PR:O75762-1
transient receptor potential cation channel subfamily A member 1 isoform 1 (human)
hTRPA1/iso:1
organism-sequence
PR:Q8BLA8-1
transient receptor potential cation channel subfamily A member 1 isoform 1 (mouse)
mTRPA1/iso:1
Yes
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:Q8BLA8
mTRPA1
acts_upstream_of_or_within
GO:0006816
calcium ion transport
PMID:18398506
GO:0009409
response to cold
PMID:12654248
;
PMID:16630838
GO:0009410
response to xenobiotic stimulus
PMID:18272293
GO:0042542
response to hydrogen peroxide
PMID:18398506
GO:0048265
response to pain
PMID:18297068
GO:0048265
response to pain
PMID:18297068
GO:0050955
thermoception
PMID:12654248
GO:0050966
detection of mechanical stimulus involved in sensory perception of pain
PMID:16630838
GO:0050968
detection of chemical stimulus involved in sensory perception of pain
PMID:18398506
GO:0050968
detection of chemical stimulus involved in sensory perception of pain
PMID:18398506
GO:0050968
detection of chemical stimulus involved in sensory perception of pain
PMID:18398506
GO:0050968
detection of chemical stimulus involved in sensory perception of pain
PMID:18398506
GO:0050968
detection of chemical stimulus involved in sensory perception of pain
PMID:18398506
enables
GO:0005216
monoatomic ion channel activity
PMID:15483558
PR:Q8BLA8-1
mTRPA1/iso:1
acts_upstream_of_or_within
GO:0006816
calcium ion transport
PMID:17588549
GO:0009409
response to cold
PMID:12654248
GO:0048265
response to pain
PMID:18272293
GO:0050955
thermoception
PMID:12654248
enables
contributes_to
GO:0005262
calcium channel activity
PMID:18398506
contributes_to
GO:0005262
calcium channel activity
PMID:18398506
contributes_to
GO:0005262
calcium channel activity
PMID:18398506
GO:0015267
channel activity
PMID:15483558
located_in
GO:0032421
stereocilium bundle
PMID:15483558
