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Protein Ontology report - transient receptor potential cation channel TRPA
PR:000000679 - http://purl.obolibrary.org/obo/PR_000000679
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000679   
  PRO nametransient receptor potential cation channel TRPA 
  Synonyms
PRO-Short-label: EXACT:fam:TRPA
  Definition"A transient receptor potential channel protein that is a member of the subfamily A of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains 14-16 copies of Ankyrin repeat (Pfam:PF00023). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means." [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB] 
  PRO Categoryfamily 
  ParentPR:000044657 transient receptor potential channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF038535
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000679

transient receptor potential cation channel TRPA

fam:TRPA


"A transient receptor potential channel protein that is a member of the subfamily A of the transient receptor potential cation channels (TRPs), with amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. The amino-terminal domain contains 14-16 copies of Ankyrin repeat (Pfam:PF00023). Most TRPs are relatively non-selective. They may be modulated by voltage changes but channel gating is generally effected by other means." [PMID:16382100, PMID:16460286, PMID:17579562, PRO:WCB]


gene



PR:000000699

transient receptor potential cation channel TRPA1

TRPA1


"A transient receptor potential cation channel TRPA that is a translation product of the human TRPA1 gene or a 1:1 ortholog thereof." [PRO:HJD]


organism-gene



PR:O75762

transient receptor potential cation channel subfamily A member 1 (human)

hTRPA1


"A transient receptor potential cation channel TRPA1 that is encoded in the genome of human." [PRO:HJD, UniProtKB:O75762]


organism-sequence



PR:O75762-1

transient receptor potential cation channel subfamily A member 1 isoform 1 (human)

hTRPA1/iso:1


"A transient receptor potential cation channel TRPA1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000075852

transient receptor potential cation channel subfamily A member 1 deaminated 1 (human)

hTRPA1/Deam:1


"A transient receptor potential cation channel subfamily A member 1 (human) that has been deaminated on the residue at the position equivalent to Asn-929 of the amino acid sequence represented by UniProtKB:O75762. UniProtKB:O75762, Asn-929, MOD:00684." [IEDB_epitope:1626619, PRO:DNx]


organism-modification



PR:000079624

transient receptor potential cation channel subfamily A member 1 methylated 1 (human)

hTRPA1/Me:1


"A transient receptor potential cation channel subfamily A member 1 (human) that has been methylated on the residue at the position equivalent to Cys-1085 of the amino acid sequence represented by UniProtKB:O75762. UniProtKB:O75762, Cys-1085, MOD:00660." [IEDB_epitope:1049025, PRO:DNx]


organism-gene



PR:Q6RI86

transient receptor potential cation channel subfamily A member 1 (rat)

rTRPA1


"A transient receptor potential cation channel TRPA1 that is encoded in the genome of rat." [OMA:Q6RI86, PRO:DNx]


organism-gene



PR:Q7Z020

transient receptor potential cation channel subfamily A member 1 (fruit fly)

fly-TRPA1


"A transient receptor potential cation channel TRPA1 that is encoded in the genome of fruit fly." [OMA:Q7Z020, PRO:DNx]


organism-sequence



PR:Q7Z020-4

transient receptor potential cation channel subfamily A member 1 isoform I (fruit fly)

fly-TRPA1/iso:I


"A transient receptor potential cation channel subfamily A member 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z020-4." [PRO:DNx, UniProtKB:Q7Z020]


organism-sequence



PR:Q7Z020-5

transient receptor potential cation channel subfamily A member 1 isoform J (fruit fly)

fly-TRPA1/iso:J


"A transient receptor potential cation channel subfamily A member 1 (fruit fly) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z020-5." [PRO:DNx, UniProtKB:Q7Z020]


organism-gene



PR:Q8BLA8

transient receptor potential cation channel subfamily A member 1 (mouse)

mTRPA1


"A transient receptor potential cation channel TRPA1 that is encoded in the genome of mouse." [OMA:Q8BLA8, PRO:DNx]

Yes

organism-sequence



PR:Q8BLA8-1

transient receptor potential cation channel subfamily A member 1 isoform 1 (mouse)

mTRPA1/iso:1


"A transient receptor potential cation channel TRPA1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

sequence



PR:000001059

transient receptor potential cation channel TRPA1 isoform 1

TRPA1/iso:1


"A transient receptor potential cation channel TRPA1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8BLA8-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:O75762-1

transient receptor potential cation channel subfamily A member 1 isoform 1 (human)

hTRPA1/iso:1


"A transient receptor potential cation channel TRPA1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8BLA8-1

transient receptor potential cation channel subfamily A member 1 isoform 1 (mouse)

mTRPA1/iso:1


"A transient receptor potential cation channel TRPA1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:Q8BLA8 mTRPA1 acts_upstream_of_or_withinGO:0006816 calcium ion transport PMID:18398506
GO:0009409 response to cold PMID:12654248; PMID:16630838
GO:0009410 response to xenobiotic stimulus PMID:18272293
GO:0042542 response to hydrogen peroxide PMID:18398506
GO:0048265 response to pain PMID:18297068
GO:0048265 response to pain PMID:18297068
GO:0050955 thermoception PMID:12654248
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain PMID:16630838
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
GO:0050968 detection of chemical stimulus involved in sensory perception of pain PMID:18398506
enablesGO:0005216 monoatomic ion channel activity PMID:15483558
PR:Q8BLA8-1 mTRPA1/iso:1 acts_upstream_of_or_withinGO:0006816 calcium ion transport PMID:17588549
GO:0009409 response to cold PMID:12654248
GO:0048265 response to pain PMID:18272293
GO:0050955 thermoception PMID:12654248
enablescontributes_to GO:0005262 calcium channel activity PMID:18398506
contributes_to GO:0005262 calcium channel activity PMID:18398506
contributes_to GO:0005262 calcium channel activity PMID:18398506
GO:0015267 channel activity PMID:15483558
located_inGO:0032421 stereocilium bundle PMID:15483558