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Protein Ontology report - voltage-gated potassium channel alpha subunit with PAS domain
PR:000000682 - http://purl.obolibrary.org/obo/PR_000000682
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000682   
  PRO namevoltage-gated potassium channel alpha subunit with PAS domain 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_sub-a_PAS
  Definition"A voltage-gated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. Unique to this class is the presence of an N-terminal PAS fold domain (Pfam:PF00989). In addition, in the cytoplasmic region downstream from S6, there is a segment that shares substantial similarity to the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) present in cyclic nucleotide-gated cation channel subunits (PR:000000674 and PR:000000674). These channels regulate membrane excitability." [PMID:8159766
  PRO Categoryfamily 
  ParentPR:000044654 voltage-gated potassium channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family4                                                  Organism-Family 0                                        
         Gene8                                                  Organism-Gene 23                                        
         Sequence15                                                  Organism-Sequence 27                                        
         Modification7                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF038287
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000682

voltage-gated potassium channel alpha subunit with PAS domain

fam:Kchan_sub-a_PAS


"A voltage-gated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. Unique to this class is the presence of an N-terminal PAS fold domain (Pfam:PF00989). In addition, in the cytoplasmic region downstream from S6, there is a segment that shares substantial similarity to the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) present in cyclic nucleotide-gated cation channel subunits (PR:000000674 and PR:000000674). These channels regulate membrane excitability." [PMID:8159766]

Yes

family



PR:000000719

voltage-gated potassium channel Eag alpha subunit

fam:Kchan_Eag_a


"A voltage-gated potassium channel alpha subunit with PAS domain whose activation is characterized by a nonsuperimposable Cole-Moore shift, in which the time course of activation becomes slower and more sigmoidal as the prepulse or holding potential is made more negative and, as a consequence, the currents do not superimpose when aligned by shifting along the time axis." [PMID:10191308, PMID:6275922]


gene



PR:000000790

voltage-gated delayed rectifier potassium channel KCNH1

KCNH1


"A voltage-gated potassium channel Eag alpha subunit that is a translation product of the human KCNH1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O95259

voltage-gated delayed rectifier potassium channel KCNH1 (human)

hKCNH1


"A voltage-gated delayed rectifier potassium channel KCNH1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O95259]


organism-sequence



PR:O95259-1

voltage-gated delayed rectifier potassium channel KCNH1 isoform 2 (human)

hKCNH1/iso:2


"A voltage-gated delayed rectifier potassium channel KCNH1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:O95259-2

voltage-gated delayed rectifier potassium channel KCNH1 isoform 1 (human)

hKCNH1/iso:1


"A voltage-gated delayed rectifier potassium channel KCNH1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-gene



PR:Q02280

potassium voltage-gated channel protein eag (fruit fly)

fly-KCNH1


"A voltage-gated delayed rectifier potassium channel KCNH1 that is encoded in the genome of fruit fly." [OMA:Q02280, PRO:CNA]


organism-gene



PR:Q60603

voltage-gated delayed rectifier potassium channel KCNH1 (mouse)

mKCNH1


"A voltage-gated delayed rectifier potassium channel KCNH1 that is encoded in the genome of mouse." [OMA:Q60603, PRO:DNx]


organism-gene



PR:Q63472

voltage-gated delayed rectifier potassium channel KCNH1 (rat)

rKCNH1


"A voltage-gated delayed rectifier potassium channel KCNH1 that is encoded in the genome of rat." [OMA:Q63472, PRO:DNx]


sequence



PR:000000955

voltage-gated delayed rectifier potassium channel KCNH1 isoform 1

KCNH1/iso:1


"A voltage-gated delayed rectifier potassium channel KCNH1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95259-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O95259-2

voltage-gated delayed rectifier potassium channel KCNH1 isoform 1 (human)

hKCNH1/iso:1


"A voltage-gated delayed rectifier potassium channel KCNH1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

modification



PR:000002664

voltage-gated delayed rectifier potassium channel KCNH1 isoform 1 unmodified form

KCNH1/iso:1/UnMod


"A voltage-gated delayed rectifier potassium channel KCNH1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


sequence



PR:000000956

voltage-gated delayed rectifier potassium channel KCNH1 isoform 2

KCNH1/iso:2


"A voltage-gated delayed rectifier potassium channel KCNH1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95259-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O95259-1

voltage-gated delayed rectifier potassium channel KCNH1 isoform 2 (human)

hKCNH1/iso:2


"A voltage-gated delayed rectifier potassium channel KCNH1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000000794

voltage-gated delayed rectifier potassium channel KCNH5

KCNH5


"A voltage-gated potassium channel Eag alpha subunit that is a translation product of the human KCNH5 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q8NCM2

voltage-gated delayed rectifier potassium channel KCNH5 (human)

hKCNH5


"A voltage-gated delayed rectifier potassium channel KCNH5 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8NCM2]

Yes

organism-sequence



PR:Q8NCM2-1

voltage-gated delayed rectifier potassium channel KCNH5 isoform 1 (human)

hKCNH5/iso:1


"A voltage-gated delayed rectifier potassium channel KCNH5 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8NCM2-2

voltage-gated delayed rectifier potassium channel KCNH5 isoform 2 (human)

hKCNH5/iso:2


"A voltage-gated delayed rectifier potassium channel KCNH5 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8NCM2-3

voltage-gated delayed rectifier potassium channel KCNH5 isoform 3 (human)

hKCNH5/iso:3


"A voltage-gated delayed rectifier potassium channel KCNH5 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-gene



PR:Q920E3

voltage-gated delayed rectifier potassium channel KCNH5 (mouse)

mKCNH5


"A voltage-gated delayed rectifier potassium channel KCNH5 that is encoded in the genome of mouse." [OMA:Q920E3, PRO:DNx]


organism-sequence



PR:Q920E3-1

potassium voltage-gated channel subfamily H member 5 isoform 1 (mouse)

mKCNH5/iso:1


"A voltage-gated delayed rectifier potassium channel KCNH5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q9EPI9

voltage-gated delayed rectifier potassium channel KCNH5 (rat)

rKCNH5


"A voltage-gated delayed rectifier potassium channel KCNH5 that is encoded in the genome of rat." [OMA:Q9EPI9, PRO:DNx]


sequence



PR:000000963

voltage-gated delayed rectifier potassium channel KCNH5 isoform 1

KCNH5/iso:1


"A voltage-gated delayed rectifier potassium channel KCNH5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NCM2-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8NCM2-1

voltage-gated delayed rectifier potassium channel KCNH5 isoform 1 (human)

hKCNH5/iso:1


"A voltage-gated delayed rectifier potassium channel KCNH5 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q920E3-1

potassium voltage-gated channel subfamily H member 5 isoform 1 (mouse)

mKCNH5/iso:1


"A voltage-gated delayed rectifier potassium channel KCNH5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000964

voltage-gated delayed rectifier potassium channel KCNH5 isoform 2

KCNH5/iso:2


"A voltage-gated delayed rectifier potassium channel KCNH5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NCM2-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN, RefSeq:NP_758963]


organism-sequence



PR:Q8NCM2-2

voltage-gated delayed rectifier potassium channel KCNH5 isoform 2 (human)

hKCNH5/iso:2


"A voltage-gated delayed rectifier potassium channel KCNH5 isoform 2 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000965

voltage-gated delayed rectifier potassium channel KCNH5 isoform 3

KCNH5/iso:3


"A voltage-gated delayed rectifier potassium channel KCNH5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NCM2-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN, RefSeq:NP_758964]


organism-sequence



PR:Q8NCM2-3

voltage-gated delayed rectifier potassium channel KCNH5 isoform 3 (human)

hKCNH5/iso:3


"A voltage-gated delayed rectifier potassium channel KCNH5 isoform 3 that is encoded in the genome of human." [PRO:CNA]


family



PR:000000720

voltage-gated potassium channel Elk alpha subunit

fam:Kchan_Elk_a


"A voltage-gated potassium channel alpha subunit with PAS domain that contains the PRINTS signature ELKCHANNEL (PRINTS:PR01465) consisting of a 6-element fingerprint. Includes the products of the mammalian KCNH3, KCNH4 and KCNH8 genes." [PRINTS:PR01465, PRO:CNA]


gene



PR:000000792

voltage-gated inwardly rectifying potassium channel KCNH3

KCNH3


"A voltage-gated potassium channel Elk alpha subunit that is a translation product of the human KCNH3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O89047

voltage-gated inwardly rectifying potassium channel KCNH3 (rat)

rKCNH3


"A voltage-gated inwardly rectifying potassium channel KCNH3 that is encoded in the genome of rat." [OMA:O89047, PRO:DNx]


organism-gene



PR:Q9ULD8

voltage-gated inwardly rectifying potassium channel KCNH3 (human)

hKCNH3


"A voltage-gated inwardly rectifying potassium channel KCNH3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9ULD8]


organism-sequence



PR:Q9ULD8-1

voltage-gated inwardly rectifying potassium channel KCNH3 isoform 1 (human)

hKCNH3/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH3 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-gene



PR:Q9WVJ0

voltage-gated inwardly rectifying potassium channel KCNH3 (mouse)

mKCNH3


"A voltage-gated inwardly rectifying potassium channel KCNH3 that is encoded in the genome of mouse." [OMA:Q9WVJ0, PRO:DNx]


sequence



PR:000000961

voltage-gated inwardly rectifying potassium channel KCNH3 isoform 1

KCNH3/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ULD8-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9ULD8-1

voltage-gated inwardly rectifying potassium channel KCNH3 isoform 1 (human)

hKCNH3/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH3 isoform 1 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000000793

voltage-gated potassium channel KCNH4

KCNH4


"A voltage-gated potassium channel Elk alpha subunit that is a translation product of the human KCNH4 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q9R1T9

voltage-gated delayed rectifier potassium channel KCNH4 (rat)

rKCNH4


"A voltage-gated potassium channel KCNH4 that is encoded in the genome of rat." [OMA:Q9R1T9, PRO:DNx]


organism-gene



PR:Q9UQ05

voltage-gated delayed rectifier potassium channel KCNH4 (human)

hKCNH4


"A voltage-gated potassium channel KCNH4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UQ05]


organism-sequence



PR:Q9UQ05-1

voltage-gated delayed rectifier potassium channel KCNH4 isoform 1 (human)

hKCNH4/iso:1


"A voltage-gated potassium channel KCNH4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000962

voltage-gated potassium channel KCNH4 isoform 1

KCNH4/iso:1


"A voltage-gated potassium channel KCNH4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UQ05-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9UQ05-1

voltage-gated delayed rectifier potassium channel KCNH4 isoform 1 (human)

hKCNH4/iso:1


"A voltage-gated potassium channel KCNH4 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

gene



PR:000000797

voltage-gated delayed rectifier potassium channel KCNH8

KCNH8


"A voltage-gated potassium channel Elk alpha subunit that is a translation product of the human KCNH8 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P59111

voltage-gated delayed rectifier potassium channel KCNH8 (mouse)

mKCNH8


"A voltage-gated delayed rectifier potassium channel KCNH8 that is encoded in the genome of mouse." [OMA:P59111, PRO:DNx]


organism-gene



PR:Q96L42

voltage-gated delayed rectifier potassium channel KCNH8 (human)

hKCNH8


"A voltage-gated delayed rectifier potassium channel KCNH8 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96L42]

Yes

organism-sequence



PR:Q96L42-1

voltage-gated delayed rectifier potassium channel KCNH8 isoform h1 (human)

hKCNH8/iso:h1


"A voltage-gated delayed rectifier potassium channel KCNH8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96L42-1." [PRO:DNx, UniProtKB:Q96L42]


organism-sequence



PR:Q96L42-2

voltage-gated delayed rectifier potassium channel KCNH8 isoform h2 (human)

hKCNH8/iso:h2


"A voltage-gated delayed rectifier potassium channel KCNH8 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96L42-2." [PRO:DNx, UniProtKB:Q96L42]


organism-modification



PR:000065070

voltage-gated delayed rectifier potassium channel KCNH8 deaminated 1 (human)

hKCNH8/Deam:1


"A voltage-gated delayed rectifier potassium channel KCNH8 (human) that has been deaminated on the residue at the position equivalent to Gln-548 of the amino acid sequence represented by UniProtKB:Q96L42-1. Example: UniProtKB:Q96L42-1, Gln-548, MOD:00685." [IEDB_epitope:1983398, PRO:DNx]


organism-gene



PR:Q9QWS8

voltage-gated delayed rectifier potassium channel KCNH8 (rat)

rKCNH8


"A voltage-gated delayed rectifier potassium channel KCNH8 that is encoded in the genome of rat." [OMA:Q9QWS8, PRO:DNx]


family



PR:000000721

voltage-gated potassium channel Erg alpha subunit

fam:Kchan_Erg_a


"A voltage-gated potassium channel alpha subunit with PAS domain that is characterized by its nanomolar sensitivity to class III antiarrhythmic drugs." [PMID:7604285]


gene



PR:000000791

voltage-gated inwardly rectifying potassium channel KCNH2

KCNH2


"A voltage-gated potassium channel Erg alpha subunit that is a translation product of the human KCNH2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O08962

voltage-gated inwardly rectifying potassium channel KCNH2 (rat)

rKCNH2


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is encoded in the genome of rat." [OMA:O08962, PRO:DNx]


organism-gene



PR:O35219

voltage-gated inwardly rectifying potassium channel KCNH2 (mouse)

mKCNH2


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is encoded in the genome of mouse." [OMA:O35219, PRO:DNx]


organism-sequence



PR:O35219-1

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)

mKCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036582

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in mouse. UniProtKB:O35219-1, Asn-600, MOD:00160." [PMID:14668215, PRO:CNA]

Yes

organism-sequence



PR:O35219-2

voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' (mouse)

mKCNH2/iso:1A'


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]

Yes

organism-sequence



PR:O35219-3

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (mouse)

mKCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform B that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]

Yes

organism-gene



PR:Q12809

voltage-gated inwardly rectifying potassium channel KCNH2 (human)

hKCNH2


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q12809]

Yes

organism-sequence



PR:Q12809-1

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)

hKCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036581

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000036583

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]

Yes

organism-modification



PR:000045392

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000045393

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]

Yes

organism-sequence



PR:Q12809-2

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)

hKCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

organism-sequence



PR:Q12809-4

voltage-gated inwardly rectifying potassium channel KCNH2 isoform h4 (human)

hKCNH2/iso:h4


"A voltage-gated inwardly rectifying potassium channel KCNH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-4." [PRO:DNx, UniProtKB:Q12809]


organism-sequence



PR:Q12809-5

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)

hKCNH2/iso:A-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

organism-sequence



PR:Q12809-6

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B-USO (human)

hKCNH2/iso:B-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-6." [PRO:DNx, UniProtKB:Q12809]


organism-sequence



PR:Q12809-7

voltage-gated inwardly rectifying potassium channel KCNH2 isoform h3.1 (human)

hKCNH2/iso:h3.1


"A voltage-gated inwardly rectifying potassium channel KCNH2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-7." [PRO:DNx, UniProtKB:Q12809]


sequence



PR:000000957

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A

KCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O35219-1

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (mouse)

mKCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036582

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in mouse. UniProtKB:O35219-1, Asn-600, MOD:00160." [PMID:14668215, PRO:CNA]

Yes

organism-sequence



PR:Q12809-1

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human)

hKCNH2/iso:A


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036581

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000036583

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]

Yes

organism-modification



PR:000045392

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000045393

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]

Yes

modification



PR:000000989

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A glycosylated form

KCNH2/iso:A/GlycoRes+


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that includes at least one glycosylated residue." [PRO:CNA]


modification



PR:000000998

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1

KCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A glycosylated form that has been glycosylated at the Asn residue within the Nx[T/S] motif located approximately 26 amino acids downstream of the S5 transmembrane domain. Example: UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277]


organism-modification



PR:000036581

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (human)

hKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, MOD:00160." [PMID:12063277, PRO:CNA]

Yes

organism-modification



PR:000036582

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 (mouse)

mKCNH2/iso:A/NGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A N-glycosylated 1 in mouse. UniProtKB:O35219-1, Asn-600, MOD:00160." [PMID:14668215, PRO:CNA]

Yes

modification



PR:000000990

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated form

KCNH2/iso:A/PhosRes+


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000999

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1

KCNH2/iso:A/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated form in which the phosphorylation occurs at Ser and Thr residues located in the intracellular loops by PKA." [PMID:10837251]


organism-modification



PR:000036583

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 (human)

hKCNH2/iso:A/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A phosphorylated 1 in human." [PMID:10837251, PRO:CNA]

Yes

modification



PR:000002666

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unmodified form

KCNH2/iso:A/UnMod


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


organism-modification



PR:000045393

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unphosphorylated form (human)

hKCNH2/iso:A/PhosRes-


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A (human) that lacks phosphorylated residues." [PMID:10837251, PRO:CNA]

Yes

modification



PR:000045391

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1

KCNH2/iso:A/UnGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A that lacks a glycosylated Asn residue in the Nx[T/S] motif located approximately 26 amino acids downstream of the S5 transmembrane domain. Example: UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277]


organism-modification



PR:000045392

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 (human)

hKCNH2/iso:A/UnGlyco:1


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A unglycosylated 1 in human. UniProtKB:Q12809-1, Asn-598, PR:000026291." [PMID:12063277, PRO:CNA]

Yes

sequence



PR:000000958

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B

KCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-2 or a 1:1 ortholog thereof." [PMID:9351446, PMID:9351462, PRO:CNA, PRO:DAN]


organism-sequence



PR:O35219-3

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (mouse)

mKCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform B that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]

Yes

organism-sequence



PR:Q12809-2

voltage-gated inwardly rectifying potassium channel KCNH2 isoform B (human)

hKCNH2/iso:B


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform B that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

sequence



PR:000000959

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO

KCNH2/iso:A-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12809-5 or a 1:1 ortholog thereof." [PMID:9765245, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q12809-5

voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO (human)

hKCNH2/iso:A-USO


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform A-USO that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12809]

Yes

sequence



PR:000000960

voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A'

KCNH2/iso:1A'


"A voltage-gated inwardly rectifying potassium channel KCNH2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35219-2 or a 1:1 ortholog thereof." [PMID:9351462, PRO:CNA, PRO:DAN]


organism-sequence



PR:O35219-2

voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' (mouse)

mKCNH2/iso:1A'


"A voltage-gated inwardly rectifying potassium channel KCNH2 isoform 1A' that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O35219]

Yes

gene



PR:000000795

voltage-gated inwardly rectifying potassium channel KCNH6

KCNH6


"A voltage-gated potassium channel Erg alpha subunit that is a translation product of the human KCNH6 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O54853

voltage-gated inwardly rectifying potassium channel KCNH6 (rat)

rKCNH6


"A voltage-gated inwardly rectifying potassium channel KCNH6 that is encoded in the genome of rat." [OMA:O54853, PRO:DNx]


organism-gene



PR:Q9H252

voltage-gated inwardly rectifying potassium channel KCNH6 (human)

hKCNH6


"A voltage-gated inwardly rectifying potassium channel KCNH6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9H252]


organism-sequence



PR:Q9H252-1

voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1 (human)

hKCNH6/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9H252-2

voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2 (human)

hKCNH6/iso:2


"A voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9H252-3

voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3 (human)

hKCNH6/iso:3


"A voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9H252-4

voltage-gated inwardly rectifying potassium channel KCNH6 isoform h1 (human)

hKCNH6/iso:h1


"A voltage-gated inwardly rectifying potassium channel KCNH6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H252-4." [PRO:DNx, UniProtKB:Q9H252]


organism-modification



PR:000067679

voltage-gated inwardly rectifying potassium channel KCNH6 phosphorylated 1 (human)

hKCNH6/Phos:1


"A voltage-gated inwardly rectifying potassium channel KCNH6 (human) that has been phosphorylated on the residue at the position equivalent to Ser-911 of the amino acid sequence represented by UniProtKB:Q9H252-4. Example: UniProtKB:Q9H252-4, Ser-911, MOD:00046." [IEDB_epitope:2147505, PRO:DNx]


sequence



PR:000000966

voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1

KCNH6/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H252-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9H252-1

voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1 (human)

hKCNH6/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH6 isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000967

voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2

KCNH6/iso:2


"A voltage-gated inwardly rectifying potassium channel KCNH6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H252-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9H252-2

voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2 (human)

hKCNH6/iso:2


"A voltage-gated inwardly rectifying potassium channel KCNH6 isoform 2 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000968

voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3

KCNH6/iso:3


"A voltage-gated inwardly rectifying potassium channel KCNH6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H252-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9H252-3

voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3 (human)

hKCNH6/iso:3


"A voltage-gated inwardly rectifying potassium channel KCNH6 isoform 3 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000000796

voltage-gated inwardly rectifying potassium channel KCNH7

KCNH7


"A voltage-gated potassium channel Erg alpha subunit that is a translation product of the human KCNH7 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O54852

voltage-gated inwardly rectifying potassium channel KCNH7 (rat)

rKCNH7


"A voltage-gated inwardly rectifying potassium channel KCNH7 that is encoded in the genome of rat." [OMA:O54852, PRO:DNx]


organism-sequence



PR:O54852-1

voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 (rat)

rKCNH7/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q9ER47

voltage-gated inwardly rectifying potassium channel KCNH7 (mouse)

mKCNH7


"A voltage-gated inwardly rectifying potassium channel KCNH7 that is encoded in the genome of mouse." [OMA:Q9ER47, PRO:DNx]


organism-sequence



PR:Q9ER47-1

voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 (mouse)

mKCNH7/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q9NS40

voltage-gated inwardly rectifying potassium channel KCNH7 (human)

hKCNH7


"A voltage-gated inwardly rectifying potassium channel KCNH7 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9NS40]


organism-sequence



PR:Q9NS40-1

voltage-gated inwardly rectifying potassium channel KCNH7 isoform h1 (human)

hKCNH7/iso:h1


"A voltage-gated inwardly rectifying potassium channel KCNH7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NS40-1." [PRO:DNx, UniProtKB:Q9NS40]


organism-sequence



PR:Q9NS40-2

voltage-gated inwardly rectifying potassium channel KCNH7 isoform h2 (human)

hKCNH7/iso:h2


"A voltage-gated inwardly rectifying potassium channel KCNH7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NS40-2." [PRO:DNx, UniProtKB:Q9NS40]


organism-modification



PR:000068261

voltage-gated inwardly rectifying potassium channel KCNH7 deaminated 1 (human)

hKCNH7/Deam:1


"A voltage-gated inwardly rectifying potassium channel KCNH7 (human) that has been deaminated on the residue at the position equivalent to Gln-1058 of the amino acid sequence represented by UniProtKB:Q9NS40-1. Example: UniProtKB:Q9NS40-1, Gln-1058, MOD:00685." [IEDB_epitope:1996097, PRO:DNx]


sequence



PR:000043159

voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1

KCNH7/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ER47-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O54852-1

voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 (rat)

rKCNH7/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q9ER47-1

voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 (mouse)

mKCNH7/iso:1


"A voltage-gated inwardly rectifying potassium channel KCNH7 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000682 fam:Kchan_sub-a_PAS
These channels regulate membrane excitability
enablescontributes_to GO:0005249 voltage-gated potassium channel activity PIRSF:PIRSF038287
located_inGO:0008076 voltage-gated potassium channel complex PIRSF:PIRSF038287
PR:000036581 hKCNH2/iso:A/NGlyco:1
UniProtKB:Q12809-1, Asn-598, MOD:00160
located_inGO:0008076 voltage-gated potassium channel complex PMID:12063277
GO:0009986 cell surface PMID:12063277
PR:000036582 mKCNH2/iso:A/NGlyco:1
UniProtKB:O35219-1, Asn-600, MOD:00160
located_inGO:0005886 plasma membrane MGI_ref:3040012; PMID:14668215
PR:000036583 hKCNH2/iso:A/Phos:1 enablesdecreased GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod PMID:10837251
located_inGO:0008076 voltage-gated potassium channel complex PMID:10837251
PR:000045392 hKCNH2/iso:A/UnGlyco:1
UniProtKB:Q12809-1, Asn-598, PR:000026291
located_inGO:0009986 cell surface PMID:12063277
PR:000045393 hKCNH2/iso:A/PhosRes- enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10837251; PMID:9351446
PR:O35219-1 mKCNH2/iso:A enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446; PMID:9351462
located_inGO:0005635 nuclear envelope MGI_ref:3040012; PMID:14668215
GO:0005635 nuclear envelope MGI_ref:3040012; PMID:14668215
GO:0005737 cytoplasm MGI_ref:3040012; PMID:14668215
GO:0005737 cytoplasm MGI_ref:3040012; PMID:14668215
GO:0005886 plasma membrane MGI_ref:3040012; PMID:14668215
GO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:O35219-2 mKCNH2/iso:1A' enablesGO:0005251 delayed rectifier potassium channel activity PMID:9351462
located_inGO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:O35219-3 mKCNH2/iso:B enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446; PMID:9351462
located_inGO:0008076 voltage-gated potassium channel complex PMID:9351462
PR:O95259-2 hKCNH1/iso:1 acts_upstream_of_or_withinGO:0007520 myoblast fusion PMID:9738473
enablesGO:0005251 delayed rectifier potassium channel activity PMID:9738473
GO:0005516 calmodulin binding PMID:10880439
located_inGO:0008076 voltage-gated potassium channel complex PMID:11943152; PMID:9738473
PR:Q12809 hKCNH2 acts_upstream_of_or_withinGO:0006936 muscle contraction PMID:7736582
GO:0008016 regulation of heart contraction PMID:7736582
PR:Q12809-1 hKCNH2/iso:A enablesGO:0030552 cAMP binding PMID:10837251
PR:Q12809-2 hKCNH2/iso:B enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9351446
PR:Q12809-5 hKCNH2/iso:A-USO enablesaltered|contributes_to GO:0005251 delayed rectifier potassium channel activity relative to PR:000002666 KCNH2/iso:1/UnMod PMID:9765245
located_inGO:0008076 voltage-gated potassium channel complex PMID:9765245
PR:Q8NCM2 hKCNH5 located_inGO:0008076 voltage-gated potassium channel complex PMID:11943152; PMID:9738473
PR:Q96L42 hKCNH8 enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:12890647
PR:Q9UQ05-1 hKCNH4/iso:1 located_inGO:0008076 voltage-gated potassium channel complex PMID:10455180