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Protein Ontology report - voltage-gated potassium channel subunit KQT
PR:000000684 - http://purl.obolibrary.org/obo/PR_000000684
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000684   
  PRO namevoltage-gated potassium channel subunit KQT 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_sub-KQT
  Definition"A voltage-gated potassium channel protein that has a core domain composition consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. The charged S4 segment with a basic amino acid at every third position confers their voltage sensitivity. Unlike other voltage-gated potassium channels, these proteins lack the N-terminal tetramerization domain (T1), which encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. Also, unique to this class is the presence of a carboxyl-terminal domain called the KCNQ voltage-gated potassium channel domain (Pfam:PF03520) or A-domain. Voltage-gated potassium channels are composed of tetramers of alpha subunits, with each alpha subunit containing a voltage sensor and contributing to the central pore. This pore is formed by these subunits that encircle a central ion conduction pathway. KQT channels are responsible for M-type potassium currents in the nervous and auditory systems and slow delayed rectifier K+ currents in the heart." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000044654 voltage-gated potassium channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene5                                                  Organism-Gene 13                                        
         Sequence25                                                  Organism-Sequence 137                                        
         Modification2                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF038513
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000684

voltage-gated potassium channel subunit KQT

fam:Kchan_sub-KQT


"A voltage-gated potassium channel protein that has a core domain composition consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. The charged S4 segment with a basic amino acid at every third position confers their voltage sensitivity. Unlike other voltage-gated potassium channels, these proteins lack the N-terminal tetramerization domain (T1), which encodes molecular determinants for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. Also, unique to this class is the presence of a carboxyl-terminal domain called the KCNQ voltage-gated potassium channel domain (Pfam:PF03520) or A-domain. Voltage-gated potassium channels are composed of tetramers of alpha subunits, with each alpha subunit containing a voltage sensor and contributing to the central pore. This pore is formed by these subunits that encircle a central ion conduction pathway. KQT channels are responsible for M-type potassium currents in the nervous and auditory systems and slow delayed rectifier K+ currents in the heart." [PRO:CNA]

Yes

gene



PR:000000728

voltage-gated potassium channel subunit KCNQ1

KCNQ1


"A voltage-gated potassium channel subunit KQT that is a translation product of the human KCNQ1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P51787

potassium voltage-gated channel subfamily KQT member 1 (human)

hKCNQ1


"A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P51787]


organism-sequence



PR:000000817

voltage-gated potassium channel subunit KCNQ1 sequence variant T587M (human)

hKCNQ1/var:T587M


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Met residue at the position equivalent to Thr-587 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Thr-587, CHEBI:16044." [PMID:10024302, PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000818

voltage-gated potassium channel subunit KCNQ1 sequence variant S373P (human)

hKCNQ1/var:S373P


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Pro residue at the position equivalent to Ser-373 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ser-373, CHEBI:50342." [PMID:10220144, PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000819

voltage-gated potassium channel subunit KCNQ1 sequence variant R243C (human)

hKCNQ1/var:R243C


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Cys residue at the position equivalent to Arg-243 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-243, CHEBI:29950." [PMID:10409658, PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000820

voltage-gated potassium channel subunit KCNQ1 sequence variant D317N (human)

hKCNQ1/var:D317N


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Asn residue at the position equivalent to Asp-317 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Asp-317, CHEBI:50347." [PMID:9302275, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000821

voltage-gated potassium channel subunit KCNQ1 sequence variant V310I (human)

hKCNQ1/var:V310I


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Ile residue at the position equivalent to Val-310 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Val-310, CHEBI:30009." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000822

voltage-gated potassium channel subunit KCNQ1 sequence variant S566F (human)

hKCNQ1/var:S566F


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Phe residue at the position equivalent to Ser-566 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ser-566, CHEBI:29997." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000823

voltage-gated potassium channel subunit KCNQ1 sequence variant Y315C (human)

hKCNQ1/var:Y315C


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Cys residue at the position equivalent to Tyr-315 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Tyr-315, CHEBI:29950." [PMID:10704188, PMID:9693036, PMID:9927399, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000824

voltage-gated potassium channel subunit KCNQ1 sequence variant S225L (human)

hKCNQ1/var:S225L


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Leu residue at the position equivalent to Ser-225 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ser-225, CHEBI:30006." [PMID:10704188, PMID:9927399, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000825

voltage-gated potassium channel subunit KCNQ1 sequence variant A178P (human)

hKCNQ1/var:A178P


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Pro residue at the position equivalent to Ala-178 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ala-178, CHEBI:50342." [PMID:9024139, PMID:9323054, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000826

voltage-gated potassium channel subunit KCNQ1 sequence variant A178T (human)

hKCNQ1/var:A178T


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Thr residue at the position equivalent to Ala-178 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ala-178, CHEBI:30013." [PMID:10704188, PMID:9024139, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000827

voltage-gated potassium channel subunit KCNQ1 sequence variant G189R (human)

hKCNQ1/var:G189R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Gly-189 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-189, CHEBI:29952." [PMID:10220144, PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000828

voltage-gated potassium channel subunit KCNQ1 sequence variant P448R (human)

hKCNQ1/var:P448R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Pro-448 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Pro-448, CHEBI:29952." [PMID:10704188, PRO:CNA, PRO:DAN, UniProtKB:P51787]

Yes

organism-sequence



PR:000000829

voltage-gated potassium channel subunit KCNQ1 sequence variant T309R (human)

hKCNQ1/var:T309R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Thr-309 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Thr-309, CHEBI:29952." [PMID:10704188, PRO:CNA, PRO:DAN, UniProtKB:P51787]

Yes

organism-sequence



PR:000000830

voltage-gated potassium channel subunit KCNQ1 sequence variant R591H (human)

hKCNQ1/var:R591H


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a His residue at the position equivalent to Arg-591 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-591, CHEBI:29979." [PMID:10024302, PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000831

voltage-gated potassium channel subunit KCNQ1 sequence variant R366W (human)

hKCNQ1/var:R366W


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Trp residue at the position equivalent to Arg-366 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-366, CHEBI:29954." [PMID:10704188, PMID:9693036, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000832

voltage-gated potassium channel subunit KCNQ1 sequence variant I313M (human)

hKCNQ1/var:I313M


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Met residue at the position equivalent to Ile-313 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ile-313, CHEBI:16044." [PMID:10704188, PMID:9024139, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000833

voltage-gated potassium channel subunit KCNQ1 sequence variant Y111C (human)

hKCNQ1/var:Y111C


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Cys residue at the position equivalent to Tyr-111 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Tyr-111, CHEBI:29950." [PMID:10704188, PRO:CNA, PRO:DAN, UniProtKB:P51787]

Yes

organism-sequence



PR:000000834

voltage-gated potassium channel subunit KCNQ1 sequence variant R533W (human)

hKCNQ1/var:R533W


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Trp residue at the position equivalent to Arg-533 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-533, CHEBI:29954." [PMID:10728423, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000835

voltage-gated potassium channel subunit KCNQ1 sequence variant G168R (human)

hKCNQ1/var:G168R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Gly-168 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-168, CHEBI:29952." [PMID:9693036, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000836

voltage-gated potassium channel subunit KCNQ1 sequence variant E261D (human)

hKCNQ1/var:E261D


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Asp residue at the position equivalent to Glu-261 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Glu-261, CHEBI:29958." [PMID:10704188, PRO:CNA, PRO:DAN, UniProtKB:P51787]

Yes

organism-sequence



PR:000000837

voltage-gated potassium channel subunit KCNQ1 sequence variant A371T (human)

hKCNQ1/var:A371T


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Thr residue at the position equivalent to Ala-371 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ala-371, CHEBI:30013." [PMID:10704188, PRO:CNA, PRO:DAN, UniProtKB:P51787]

Yes

organism-sequence



PR:000000838

voltage-gated potassium channel subunit KCNQ1 sequence variant 29 (human)

hKCNQ1/var:29


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a three-residue deletion at the positions equivalent to 71-73 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P49747-1, 21-70, 74-757." [PRO:CNA, PRO:DAN, UniProtKB:P51787]

Yes

organism-sequence



PR:000000839

voltage-gated potassium channel subunit KCNQ1 sequence variant A341V (human)

hKCNQ1/var:A341V


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Val residue at the position equivalent to Ala-341 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ala-341, CHEBI:30015." [PMID:10704188, PMID:8818942, PMID:8872472, PMID:9570196, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000840

voltage-gated potassium channel subunit KCNQ1 sequence variant L250H (human)

hKCNQ1/var:L250H


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a His residue at the position equivalent to Leu-250 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Leu-250, CHEBI:29979." [PMID:10704188, PRO:CNA, PRO:DAN, UniProtKB:P51787]

Yes

organism-sequence



PR:000000841

voltage-gated potassium channel subunit KCNQ1 sequence variant S349W (human)

hKCNQ1/var:S349W


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Trp residue at the position equivalent to Ser-349 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ser-349, CHEBI:29954." [PMID:10704188, PRO:CNA, PRO:DAN, UniProtKB:P51787]

Yes

organism-sequence



PR:000000842

voltage-gated potassium channel subunit KCNQ1 sequence variant T391I (human)

hKCNQ1/var:T391I


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Ile residue at the position equivalent to Thr-391 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Thr-391, CHEBI:30009." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000843

voltage-gated potassium channel subunit KCNQ1 sequence variant K318N (human)

hKCNQ1/var:K318N


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Asn residue at the position equivalent to Lys-318 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Lys-318, CHEBI:50347." [PMID:10704188, PMID:9693036, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000844

voltage-gated potassium channel subunit KCNQ1 sequence variant A344V (human)

hKCNQ1/var:A344V


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Val residue at the position equivalent to Ala-344 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ala-344, CHEBI:30015." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000845

voltage-gated potassium channel subunit KCNQ1 sequence variant A525T (human)

hKCNQ1/var:A525T


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Thr residue at the position equivalent to Ala-525 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ala-525, CHEBI:30013." [PMID:10482963, PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000846

voltage-gated potassium channel subunit KCNQ1 sequence variant A341E (human)

hKCNQ1/var:A341E


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Glu residue at the position equivalent to Ala-341 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ala-341, CHEBI:29972." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000847

voltage-gated potassium channel subunit KCNQ1 sequence variant R583C (human)

hKCNQ1/var:R583C


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Cys residue at the position equivalent to Arg-583 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-583, CHEBI:29950." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000848

voltage-gated potassium channel subunit KCNQ1 sequence variant D242N (human)

hKCNQ1/var:D242N


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Asn residue at the position equivalent to Asp-242 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Asp-242, CHEBI:50347." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000849

voltage-gated potassium channel subunit KCNQ1 sequence variant L342F (human)

hKCNQ1/var:L342F


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Phe residue at the position equivalent to Leu-342 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Leu-342, CHEBI:29997." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000850

voltage-gated potassium channel subunit KCNQ1 sequence variant G306R (human)

hKCNQ1/var:G306R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Gly-306 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-306, CHEBI:29952." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000851

voltage-gated potassium channel subunit KCNQ1 sequence variant S140G (human)

hKCNQ1/var:S140G


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Gly residue at the position equivalent to Ser-140 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ser-140, CHEBI:29947." [PMID:12522251, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000852

voltage-gated potassium channel subunit KCNQ1 sequence variant G269S (human)

hKCNQ1/var:G269S


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Ser residue at the position equivalent to Gly-269 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-269, CHEBI:29999." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000853

voltage-gated potassium channel subunit KCNQ1 sequence variant R555C (human)

hKCNQ1/var:R555C


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Cys residue at the position equivalent to Arg-555 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-555, CHEBI:29950." [PMID:10704188, PMID:9386136, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000854

voltage-gated potassium channel subunit KCNQ1 sequence variant R539W (human)

hKCNQ1/var:R539W


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Trp residue at the position equivalent to Arg-539 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-539, CHEBI:29954." [PMID:10728423, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000855

voltage-gated potassium channel subunit KCNQ1 sequence variant Y315S (human)

hKCNQ1/var:Y315S


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Ser residue at the position equivalent to Tyr-315 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Tyr-315, CHEBI:29999." [PMID:10220144, PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000856

voltage-gated potassium channel subunit KCNQ1 sequence variant R174H (human)

hKCNQ1/var:R174H


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a His residue at the position equivalent to Arg-174 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-174, CHEBI:29979." [PMID:10367071, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000857

voltage-gated potassium channel subunit KCNQ1 sequence variant A194P (human)

hKCNQ1/var:A194P


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Pro residue at the position equivalent to Ala-194 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ala-194, CHEBI:50342." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000858

voltage-gated potassium channel subunit KCNQ1 sequence variant Y184S (human)

hKCNQ1/var:Y184S


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Ser residue at the position equivalent to Tyr-184 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Tyr-184, CHEBI:29999." [PMID:10220144, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000859

voltage-gated potassium channel subunit KCNQ1 sequence variant G345E (human)

hKCNQ1/var:G345E


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Glu residue at the position equivalent to Gly-345 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-345, CHEBI:29972." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000860

voltage-gated potassium channel subunit KCNQ1 sequence variant R190Q (human)

hKCNQ1/var:R190Q


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Gln residue at the position equivalent to Arg-190 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-190, CHEBI:30011." [PMID:10704188, PMID:10728423, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000861

voltage-gated potassium channel subunit KCNQ1 sequence variant T311I (human)

hKCNQ1/var:T311I


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Ile residue at the position equivalent to Thr-311 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Thr-311, CHEBI:30009." [PMID:9482580, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000862

voltage-gated potassium channel subunit KCNQ1 sequence variant G314S (human)

hKCNQ1/var:G314S


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Ser residue at the position equivalent to Gly-314 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-314, CHEBI:29999." [PMID:8872472, PMID:9693036, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000863

voltage-gated potassium channel subunit KCNQ1 sequence variant W248R (human)

hKCNQ1/var:W248R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Trp-248 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Trp-248, CHEBI:29952." [PMID:10409658, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000864

voltage-gated potassium channel subunit KCNQ1 sequence variant R366P (human)

hKCNQ1/var:R366P


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Pro residue at the position equivalent to Arg-366 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-366, CHEBI:50342." [PMID:10704188, PMID:9024139, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000865

voltage-gated potassium channel subunit KCNQ1 sequence variant R366Q (human)

hKCNQ1/var:R366Q


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Gln residue at the position equivalent to Arg-366 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-366, CHEBI:30011." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000866

voltage-gated potassium channel subunit KCNQ1 sequence variant E160K (human)

hKCNQ1/var:E160K


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Lys residue at the position equivalent to Glu-160 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Glu-160, CHEBI:29967." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000867

voltage-gated potassium channel subunit KCNQ1 sequence variant V254M (human)

hKCNQ1/var:V254M


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Met residue at the position equivalent to Val-254 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Val-254, CHEBI:16044." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000868

voltage-gated potassium channel subunit KCNQ1 sequence variant G345R (human)

hKCNQ1/var:G345R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Gly-345 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-345, CHEBI:29952." [PMID:10220144, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000869

voltage-gated potassium channel subunit KCNQ1 sequence variant E261K (human)

hKCNQ1/var:E261K


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Lys residue at the position equivalent to Glu-261 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Glu-261, CHEBI:29967." [PMID:10409658, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000870

voltage-gated potassium channel subunit KCNQ1 sequence variant V307L (human)

hKCNQ1/var:V307L


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Leu residue at the position equivalent to Val-307 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Val-307, CHEBI:30006." [PMID:15159330, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000871

voltage-gated potassium channel subunit KCNQ1 sequence variant F339del (human)

hKCNQ1/var:F339del


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a single-residue deletion at the position equivalent to Phe-339 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P49747-1, 21-338, 340-757." [PMID:9702906, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000872

voltage-gated potassium channel subunit KCNQ1 sequence variant R243H (human)

hKCNQ1/var:R243H


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a His residue at the position equivalent to Arg-243 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-243, CHEBI:29979." [PMID:10728423, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000873

voltage-gated potassium channel subunit KCNQ1 sequence variant G179S (human)

hKCNQ1/var:G179S


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Ser residue at the position equivalent to Gly-179 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-179, CHEBI:29999." [PMID:10728423, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000874

voltage-gated potassium channel subunit KCNQ1 sequence variant A300T (human)

hKCNQ1/var:A300T


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Thr residue at the position equivalent to Ala-300 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Ala-300, CHEBI:30013." [PMID:9641694, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000875

voltage-gated potassium channel subunit KCNQ1 sequence variant R174C (human)

hKCNQ1/var:R174C


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Cys residue at the position equivalent to Arg-174 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-174, CHEBI:29950." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000876

voltage-gated potassium channel subunit KCNQ1 sequence variant W305S (human)

hKCNQ1/var:W305S


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Ser residue at the position equivalent to Trp-305 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Trp-305, CHEBI:29999." [PMID:9781056, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000877

voltage-gated potassium channel subunit KCNQ1 sequence variant L266P (human)

hKCNQ1/var:L266P


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Pro residue at the position equivalent to Leu-266 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Leu-266, CHEBI:50342." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000878

voltage-gated potassium channel subunit KCNQ1 sequence variant R594Q (human)

hKCNQ1/var:R594Q


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Gln residue at the position equivalent to Arg-594 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Arg-594, CHEBI:30011." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000879

voltage-gated potassium channel subunit KCNQ1 sequence variant L273F (human)

hKCNQ1/var:L273F


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Phe residue at the position equivalent to Leu-273 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Leu-273, CHEBI:29997." [PMID:9323054, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000880

voltage-gated potassium channel subunit KCNQ1 sequence variant Y281C (human)

hKCNQ1/var:Y281C


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Cys residue at the position equivalent to Tyr-281 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Tyr-281, CHEBI:29950." [PMID:9927399, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000881

voltage-gated potassium channel subunit KCNQ1 sequence variant P320A (human)

hKCNQ1/var:P320A


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Ala residue at the position equivalent to Pro-320 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Pro-320, CHEBI:46217." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000882

voltage-gated potassium channel subunit KCNQ1 sequence variant F157C (human)

hKCNQ1/var:F157C


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Cys residue at the position equivalent to Phe-157 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Phe-157, CHEBI:29950." [PMID:10220146, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000883

voltage-gated potassium channel subunit KCNQ1 sequence variant L353P (human)

hKCNQ1/var:L353P


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Pro residue at the position equivalent to Leu-353 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Leu-353, CHEBI:50342." [PMID:9693036, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000884

voltage-gated potassium channel subunit KCNQ1 sequence variant G325R (human)

hKCNQ1/var:G325R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Gly-325 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-325, CHEBI:29952." [PMID:9024139, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000885

voltage-gated potassium channel subunit KCNQ1 sequence variant W392R (human)

hKCNQ1/var:W392R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Trp-392 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Trp-392, CHEBI:29952." [PMID:10220144, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000886

voltage-gated potassium channel subunit KCNQ1 sequence variant G269D (human)

hKCNQ1/var:G269D


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Asp residue at the position equivalent to Gly-269 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-269, CHEBI:29958." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000887

voltage-gated potassium channel subunit KCNQ1 sequence variant G589D (human)

hKCNQ1/var:G589D


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Asp residue at the position equivalent to Gly-589 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-589, CHEBI:29958." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000888

voltage-gated potassium channel subunit KCNQ1 sequence variant G216R (human)

hKCNQ1/var:G216R


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Arg residue at the position equivalent to Gly-216 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Gly-216, CHEBI:29952." [PMID:9272155, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000889

voltage-gated potassium channel subunit KCNQ1 sequence variant V417M (human)

hKCNQ1/var:V417M


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has a Met residue at the position equivalent to Val-417 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Val-417, CHEBI:16044." [PMID:10704188, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000890

voltage-gated potassium channel subunit KCNQ1 sequence variant T312I (human)

hKCNQ1/var:T312I


"A potassium voltage-gated channel subfamily KQT member 1 (human) that has an Ile residue at the position equivalent to Thr-312 of the amino acid sequence represented by UniProtKB:P51787-1. Example: UniProtKB:P51787-1, Thr-312, CHEBI:30009." [PMID:10409658, PMID:9323054, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P51787-1

potassium voltage-gated channel subfamily KQT member 1 isoform 1 (human)

hKCNQ1/iso:1


"A voltage-gated potassium channel subunit KCNQ1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:P51787-2

potassium voltage-gated channel subfamily KQT member 1 isoform 2 (human)

hKCNQ1/iso:2


"A voltage-gated potassium channel subunit KCNQ1 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P51787]

Yes

organism-gene



PR:P97414

potassium voltage-gated channel subfamily KQT member 1 (mouse)

mKCNQ1


"A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of mouse." [OMA:P97414, PRO:DNx]


organism-sequence



PR:P97414-1

potassium voltage-gated channel subfamily KQT member 1 isoform I (mouse)

mKCNQ1/iso:I


"A potassium voltage-gated channel subfamily KQT member 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97414-1." [PRO:DNx, UniProtKB:P97414]


organism-sequence



PR:P97414-2

potassium voltage-gated channel subfamily KQT member 1 isoform II (mouse)

mKCNQ1/iso:II


"A potassium voltage-gated channel subfamily KQT member 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P97414-2." [PRO:DNx, UniProtKB:P97414]


organism-gene



PR:Q9Z0N7

potassium voltage-gated channel subfamily KQT member 1 (rat)

rKCNQ1


"A voltage-gated potassium channel subunit KCNQ1 that is encoded in the genome of rat." [OMA:Q9Z0N7, PRO:DNx]


sequence



PR:000000815

voltage-gated potassium channel subunit KCNQ1 isoform 1

KCNQ1/iso:1


"A voltage-gated potassium channel subunit KCNQ1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51787-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P51787-1

potassium voltage-gated channel subfamily KQT member 1 isoform 1 (human)

hKCNQ1/iso:1


"A voltage-gated potassium channel subunit KCNQ1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

modification



PR:000002622

voltage-gated potassium channel subunit KCNQ1 isoform 1 unmodified form

KCNQ1/iso:1/UnMod


"A voltage-gated potassium channel subunit KCNQ1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


sequence



PR:000000816

voltage-gated potassium channel subunit KCNQ1 isoform 2

KCNQ1/iso:2


"A voltage-gated potassium channel subunit KCNQ1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P51787-2 or a 1:1 ortholog thereof." [PMID:9305853, PRO:CNA, PRO:DAN]


organism-sequence



PR:P51787-2

potassium voltage-gated channel subfamily KQT member 1 isoform 2 (human)

hKCNQ1/iso:2


"A voltage-gated potassium channel subunit KCNQ1 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P51787]

Yes

gene



PR:000000729

voltage-gated potassium channel subunit KCNQ2

KCNQ2


"A voltage-gated potassium channel subunit KQT that is a translation product of the human KCNQ2 gene or a 1:1 ortholog thereof. Most of the isoforms are generated by splicing that is restricted to a region that encodes the intracellular C-terminal domain of the channel (exons 7-16 in rat). From these, there are two main classes, one containing exon 16 in-frame, and others with an alternative splice junction in exon 14 that results in a frameshift and early termination. In addition, exons 12 and 13 have alternative splice junctions, and exons 8,11, and 15a are subject to splicing. Many members of this class can form heteromeric channels with members of the class KCNQ3 (PR:000000730). Some forms of KCNQ2 contain two binding calmodulin binding sites and calmodulin is tethered constitutively to KCNQ channels." [PMID:11230508, PMID:12223552]


organism-gene



PR:O43526

potassium voltage-gated channel subfamily KQT member 2 (human)

hKCNQ2


"A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human." []


organism-sequence



PR:000000907

voltage-gated potassium channel subunit KCNQ2 sequence variant S247W (human)

hKCNQ2/var:S247W


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Trp residue at the position equivalent to Ser-247 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Ser-247, CHEBI:29954." [PMID:12742592, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000908

voltage-gated potassium channel subunit KCNQ2 sequence variant H228Q (human)

hKCNQ2/var:H228Q


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Gln residue at the position equivalent to His-228 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, His-228, CHEBI:30011." [PMID:14534157, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000909

voltage-gated potassium channel subunit KCNQ2 sequence variant R207W (human)

hKCNQ2/var:R207W


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Trp residue at the position equivalent to Arg-207 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Arg-207, CHEBI:29954." [PMID:11572947, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000910

voltage-gated potassium channel subunit KCNQ2 sequence variant L243F (human)

hKCNQ2/var:L243F


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Phe residue at the position equivalent to Leu-243 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Leu-243, CHEBI:29997." [PMID:14534157, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000911

voltage-gated potassium channel subunit KCNQ2 sequence variant 4 (human)

hKCNQ2/var:4


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a change of one of the innermost Arg residues of the key functional voltage sensor (S4) region. Example: UniProtKB:O43526-1, Arg-214, CHEBI:29954." [PMID:11175290, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000912

voltage-gated potassium channel subunit KCNQ2 sequence variant Y284C (human)

hKCNQ2/var:Y284C


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Cys residue at the position equivalent to Tyr-284 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Tyr-284, CHEBI:29950." [PMID:10788442, PMID:9425895, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000913

voltage-gated potassium channel subunit KCNQ2 sequence variant A306T (human)

hKCNQ2/var:A306T


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Thr residue at the position equivalent to Ala-306 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Ala-306, CHEBI:30013." [PMID:10788442, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000914

voltage-gated potassium channel subunit KCNQ2 sequence variant R333Q (human)

hKCNQ2/var:R333Q


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Gln residue at the position equivalent to Arg-333 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Arg-333, CHEBI:30011." [PMID:14534157, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000915

voltage-gated potassium channel subunit KCNQ2 sequence variant M208V (human)

hKCNQ2/var:M208V


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has a Val residue at the position equivalent to Met-208 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Met-208, CHEBI:30015." [PMID:14534157, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:O43526-1

potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human)

hKCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:O43526-2

potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human)

hKCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O43526-3

potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human)

hKCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 isoform 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:000000916

voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human)

hKCNQ2/iso:3/var:K526N


"A potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human) that has an Asn residue at the position equivalent to Lys-526 of the amino acid sequence represented by UniProtKB:O43526-3. UniProtKB:O43526-3, Lys-526, CHEBI:50347." [PMID:15249611, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:O43526-4

potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human)

hKCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 isoform 4 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O43526-5

potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human)

hKCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 isoform 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:O43526-6

potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human)

hKCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 isoform 6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]

Yes

organism-modification



PR:000076442

potassium voltage-gated channel subfamily KQT member 2 acetylated 1 (human)

hKCNQ2/Ac:1


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has been acetylated on the residue at the position equivalent to Lys-69 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Lys-69, MOD:00723." [IEDB_epitope:1779391, PRO:DNx]


organism-modification



PR:000079703

potassium voltage-gated channel subfamily KQT member 2 phosphorylated 1 (human)

hKCNQ2/Phos:1


"A potassium voltage-gated channel subfamily KQT member 2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-74 of the amino acid sequence represented by UniProtKB:O43526-1. Example: UniProtKB:O43526-1, Tyr-74, MOD:00048." [IEDB_epitope:2147317, PRO:DNx]


organism-gene



PR:O88943

potassium voltage-gated channel subfamily KQT member 2 (rat)

rKCNQ2


"A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-1

potassium voltage-gated channel subfamily KQT member 2 isoform A (rat)

rKCNQ2/iso:A


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-sequence



PR:O88943-2

potassium voltage-gated channel subfamily KQT member 2 isoform B (rat)

rKCNQ2/iso:B


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-2." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-3

potassium voltage-gated channel subfamily KQT member 2 isoform C (rat)

rKCNQ2/iso:C


"A voltage-gated potassium channel subunit KCNQ2 isoform 3 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-4

potassium voltage-gated channel subfamily KQT member 2 isoform D (rat)

rKCNQ2/iso:D


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-4." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-5

potassium voltage-gated channel subfamily KQT member 2 isoform E (rat)

rKCNQ2/iso:E


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-5." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-6

potassium voltage-gated channel subfamily KQT member 2 isoform F (rat)

rKCNQ2/iso:F


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-6." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-7

potassium voltage-gated channel subfamily KQT member 2 isoform G (rat)

rKCNQ2/iso:G


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-7." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-8

potassium voltage-gated channel subfamily KQT member 2 isoform H (rat)

rKCNQ2/iso:H


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-8." [PRO:DNx, UniProtKB:O88943]


organism-sequence



PR:O88943-9

potassium voltage-gated channel subfamily KQT member 2 isoform I (rat)

rKCNQ2/iso:I


"A potassium voltage-gated channel subfamily KQT member 2 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88943-9." [PRO:DNx, UniProtKB:O88943]


organism-gene



PR:Q9Z351

potassium voltage-gated channel subfamily KQT member 2 (mouse)

mKCNQ2


"A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of mouse." [OMA:Q9Z351, PRO:DNx]


organism-sequence



PR:Q9Z351-1

potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse)

mKCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-10

potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse)

mKCNQ2/iso:10


"A voltage-gated potassium channel subunit KCNQ2 isoform 10 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

organism-sequence



PR:Q9Z351-11

potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse)

mKCNQ2/iso:11


"A voltage-gated potassium channel subunit KCNQ2 isoform 11 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

organism-sequence



PR:Q9Z351-12

potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse)

mKCNQ2/iso:12


"A voltage-gated potassium channel subunit KCNQ2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

organism-sequence



PR:Q9Z351-13

potassium voltage-gated channel subfamily KQT member 2 isoform m13 (mouse)

mKCNQ2/iso:m13


"A potassium voltage-gated channel subfamily KQT member 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-13." [PRO:DNx, UniProtKB:Q9Z351]


organism-sequence



PR:Q9Z351-2

potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse)

mKCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 isoform 12 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-3

potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse)

mKCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 isoform 13 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-4

potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse)

mKCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 isoform 14 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-5

potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse)

mKCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 isoform 15 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-6

potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse)

mKCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 isoform 16 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-7

potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse)

mKCNQ2/iso:7


"A voltage-gated potassium channel subunit KCNQ2 isoform 7 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-8

potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse)

mKCNQ2/iso:8


"A voltage-gated potassium channel subunit KCNQ2 isoform 8 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9Z351-9

potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse)

mKCNQ2/iso:9


"A voltage-gated potassium channel subunit KCNQ2 isoform 9 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

sequence



PR:000000891

voltage-gated potassium channel subunit KCNQ2 isoform 1

KCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-12 or a 1:1 ortholog thereof." [PMID:11230508, PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-1

potassium voltage-gated channel subfamily KQT member 2 isoform 1 (human)

hKCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:Q9Z351-12

potassium voltage-gated channel subfamily KQT member 2 isoform 12 (mouse)

mKCNQ2/iso:12


"A voltage-gated potassium channel subunit KCNQ2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

sequence



PR:000000892

voltage-gated potassium channel subunit KCNQ2 isoform 10

KCNQ2/iso:10


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-10 with unique C-terminus sequence VSLSPC or a 1:1 ortholog thereof." [PMID:9666519, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-10

potassium voltage-gated channel subfamily KQT member 2 isoform 10 (mouse)

mKCNQ2/iso:10


"A voltage-gated potassium channel subunit KCNQ2 isoform 10 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

sequence



PR:000000893

voltage-gated potassium channel subunit KCNQ2 isoform 11

KCNQ2/iso:11


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-11 or a 1:1 ortholog thereof." [PMID:9666519, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-11

potassium voltage-gated channel subfamily KQT member 2 isoform 11 (mouse)

mKCNQ2/iso:11


"A voltage-gated potassium channel subunit KCNQ2 isoform 11 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

sequence



PR:000000894

voltage-gated potassium channel subunit KCNQ2 isoform 12

KCNQ2/iso:12


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-2

potassium voltage-gated channel subfamily KQT member 2 isoform 2 (mouse)

mKCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 isoform 12 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000895

voltage-gated potassium channel subunit KCNQ2 isoform 13

KCNQ2/iso:13


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-3

potassium voltage-gated channel subfamily KQT member 2 isoform 3 (mouse)

mKCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 isoform 13 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000896

voltage-gated potassium channel subunit KCNQ2 isoform 14

KCNQ2/iso:14


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-4 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-4

potassium voltage-gated channel subfamily KQT member 2 isoform 4 (mouse)

mKCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 isoform 14 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000897

voltage-gated potassium channel subunit KCNQ2 isoform 15

KCNQ2/iso:15


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-5 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-5

potassium voltage-gated channel subfamily KQT member 2 isoform 5 (mouse)

mKCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 isoform 15 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000898

voltage-gated potassium channel subunit KCNQ2 isoform 16

KCNQ2/iso:16


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-6 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-6

potassium voltage-gated channel subfamily KQT member 2 isoform 6 (mouse)

mKCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 isoform 16 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000899

voltage-gated potassium channel subunit KCNQ2 isoform 2

KCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-2

potassium voltage-gated channel subfamily KQT member 2 isoform 2 (human)

hKCNQ2/iso:2


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O88943-1

potassium voltage-gated channel subfamily KQT member 2 isoform A (rat)

rKCNQ2/iso:A


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-sequence



PR:Q9Z351-1

potassium voltage-gated channel subfamily KQT member 2 isoform 1 (mouse)

mKCNQ2/iso:1


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000002632

voltage-gated potassium channel subunit KCNQ2 isoform 2 unmodified form

KCNQ2/iso:2/UnMod


"A voltage-gated potassium channel subunit KCNQ2 isoform 2 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


sequence



PR:000000900

voltage-gated potassium channel subunit KCNQ2 isoform 3

KCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-3 or a 1:1 ortholog thereof." [PMID:9430594, PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-3

potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human)

hKCNQ2/iso:3


"A voltage-gated potassium channel subunit KCNQ2 isoform 3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


organism-sequence



PR:000000916

voltage-gated potassium channel subunit KCNQ2 isoform 3 sequence variant K526N (human)

hKCNQ2/iso:3/var:K526N


"A potassium voltage-gated channel subfamily KQT member 2 isoform 3 (human) that has an Asn residue at the position equivalent to Lys-526 of the amino acid sequence represented by UniProtKB:O43526-3. UniProtKB:O43526-3, Lys-526, CHEBI:50347." [PMID:15249611, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:O88943-3

potassium voltage-gated channel subfamily KQT member 2 isoform C (rat)

rKCNQ2/iso:C


"A voltage-gated potassium channel subunit KCNQ2 isoform 3 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:O88943]


sequence



PR:000000901

voltage-gated potassium channel subunit KCNQ2 isoform 4

KCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-4 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-4

potassium voltage-gated channel subfamily KQT member 2 isoform 4 (human)

hKCNQ2/iso:4


"A voltage-gated potassium channel subunit KCNQ2 isoform 4 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000902

voltage-gated potassium channel subunit KCNQ2 isoform 5

KCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-5 or a 1:1 ortholog thereof." [PMID:11230508, PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-5

potassium voltage-gated channel subfamily KQT member 2 isoform 5 (human)

hKCNQ2/iso:5


"A voltage-gated potassium channel subunit KCNQ2 isoform 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]


sequence



PR:000000903

voltage-gated potassium channel subunit KCNQ2 isoform 6

KCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43526-6 or a 1:1 ortholog thereof." [PMID:9039501, PRO:CNA, PRO:DAN]


organism-sequence



PR:O43526-6

potassium voltage-gated channel subfamily KQT member 2 isoform 6 (human)

hKCNQ2/iso:6


"A voltage-gated potassium channel subunit KCNQ2 isoform 6 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43526]

Yes

sequence



PR:000000904

voltage-gated potassium channel subunit KCNQ2 isoform 7

KCNQ2/iso:7


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-7 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-7

potassium voltage-gated channel subfamily KQT member 2 isoform 7 (mouse)

mKCNQ2/iso:7


"A voltage-gated potassium channel subunit KCNQ2 isoform 7 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000905

voltage-gated potassium channel subunit KCNQ2 isoform 8

KCNQ2/iso:8


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-8 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-8

potassium voltage-gated channel subfamily KQT member 2 isoform 8 (mouse)

mKCNQ2/iso:8


"A voltage-gated potassium channel subunit KCNQ2 isoform 8 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000906

voltage-gated potassium channel subunit KCNQ2 isoform 9

KCNQ2/iso:9


"A voltage-gated potassium channel subunit KCNQ2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z351-9 or a 1:1 ortholog thereof." [PMID:9666519, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9Z351-9

potassium voltage-gated channel subfamily KQT member 2 isoform 9 (mouse)

mKCNQ2/iso:9


"A voltage-gated potassium channel subunit KCNQ2 isoform 9 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9Z351]

Yes

gene



PR:000000730

voltage-gated potassium channel subunit KCNQ3

KCNQ3


"A voltage-gated potassium channel subunit KQT that is a translation product of the human KCNQ3 gene or a 1:1 ortholog thereof. Many members of this class can form heteromeric channels with members of the class KCNQ2 (PR:000000729) or KCNQ5 with essentially identical properties to the channel underlying the native M-current." [PMID:10479678]


organism-gene



PR:O43525

potassium voltage-gated channel subfamily KQT member 3 (human)

hKCNQ3


"A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of human." []

Yes

organism-sequence



PR:O43525-1

potassium voltage-gated channel subfamily KQT member 3 isoform 1 (human)

hKCNQ3/iso:1


"A voltage-gated potassium channel subunit KCNQ3 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:O43525-2

potassium voltage-gated channel subfamily KQT member 3 isoform h2 (human)

hKCNQ3/iso:h2


"A potassium voltage-gated channel subfamily KQT member 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43525-2." [PRO:DNx, UniProtKB:O43525]


organism-gene



PR:O88944

potassium voltage-gated channel subfamily KQT member 3 (rat)

rKCNQ3


"A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of rat." [OMA:O88944, PRO:DNx]


organism-sequence



PR:O88944-1

potassium voltage-gated channel subfamily KQT member 3 isoform r1 (rat)

rKCNQ3/iso:r1


"A potassium voltage-gated channel subfamily KQT member 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88944-1." [PRO:DNx, UniProtKB:O88944]


organism-sequence



PR:O88944-2

potassium voltage-gated channel subfamily KQT member 3 isoform r2 (rat)

rKCNQ3/iso:r2


"A potassium voltage-gated channel subfamily KQT member 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88944-2." [PRO:DNx, UniProtKB:O88944]


organism-gene



PR:Q8K3F6

potassium voltage-gated channel subfamily KQT member 3 (mouse)

mKCNQ3


"A voltage-gated potassium channel subunit KCNQ3 that is encoded in the genome of mouse." [OMA:Q8K3F6, PRO:DNx]


organism-sequence



PR:Q8K3F6-1

potassium voltage-gated channel subfamily KQT member 3 isoform 1 (mouse)

mKCNQ3/iso:1


"A voltage-gated potassium channel subunit KCNQ3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000917

voltage-gated potassium channel subunit KCNQ3 isoform 1

KCNQ3/iso:1


"A voltage-gated potassium channel subunit KCNQ3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43525-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O43525-1

potassium voltage-gated channel subfamily KQT member 3 isoform 1 (human)

hKCNQ3/iso:1


"A voltage-gated potassium channel subunit KCNQ3 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8K3F6-1

potassium voltage-gated channel subfamily KQT member 3 isoform 1 (mouse)

mKCNQ3/iso:1


"A voltage-gated potassium channel subunit KCNQ3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


gene



PR:000000731

voltage-gated potassium channel subunit KCNQ4

KCNQ4


"A voltage-gated potassium channel subunit KQT that is a translation product of the human KCNQ4 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P56696

potassium voltage-gated channel subfamily KQT member 4 (human)

hKCNQ4


"A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P56696]


organism-sequence



PR:000000920

voltage-gated potassium channel subunit KCNQ4 sequence variant G285C (human)

hKCNQ4/var:G285C


"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Cys residue at the position equivalent to Gly-285 of the amino acid sequence represented by UniProtKB:P56696-1. This variation is at the first Gly in the conserved selectivity filter sequence GYGD within the pore region. Example: UniProtKB:P56696-1, Gly-285, CHEBI:29950." [PMID:10369879, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000921

voltage-gated potassium channel subunit KCNQ4 sequence variant L274H (human)

hKCNQ4/var:L274H


"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a His residue at the position equivalent to Leu-274 of the amino acid sequence represented by UniProtKB:P56696-1. Example: UniProtKB:P56696-1, Leu-274, CHEBI:29979." [PMID:10925378, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000922

voltage-gated potassium channel subunit KCNQ4 sequence variant G285S (human)

hKCNQ4/var:G285S


"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Ser residue at the position equivalent to Gly-285 of the amino acid sequence represented by UniProtKB:P56696-1. This variation is at the first Gly in the conserved selectivity filter sequence GYGD within the pore region. Example: UniProtKB:P56696-1, Gly-285, CHEBI:29999." [PMID:10025409, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000923

voltage-gated potassium channel subunit KCNQ4 sequence variant L281S (human)

hKCNQ4/var:L281S


"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Ser residue at the position equivalent to Leu-281 of the amino acid sequence represented by UniProtKB:P56696-1. Example: UniProtKB:P56696-1, Leu-281, CHEBI:29999." [PMID:10571947, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000924

voltage-gated potassium channel subunit KCNQ4 sequence variant W276S (human)

hKCNQ4/var:W276S


"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Ser residue at the position equivalent to Trp-276 of the amino acid sequence represented by UniProtKB:P56696-1. Example: UniProtKB:P56696-1, Trp-276, CHEBI:29999." [PMID:10369879, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000925

voltage-gated potassium channel subunit KCNQ4 sequence variant G321S (human)

hKCNQ4/var:G321S


"A potassium voltage-gated channel subfamily KQT member 4 (human) that has a Ser residue at the position equivalent to Gly-321 of the amino acid sequence represented by UniProtKB:P56696-1. Example: UniProtKB:P56696-1, Gly-321, CHEBI:29999." [PMID:10369879, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P56696-1

potassium voltage-gated channel subfamily KQT member 4 isoform 1 (human)

hKCNQ4/iso:1


"A voltage-gated potassium channel subunit KCNQ4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:P56696-2

potassium voltage-gated channel subfamily KQT member 4 isoform 2 (human)

hKCNQ4/iso:2


"A voltage-gated potassium channel subunit KCNQ4 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P56696]


organism-gene



PR:Q9JK97

potassium voltage-gated channel subfamily KQT member 4 (mouse)

mKCNQ4


"A voltage-gated potassium channel subunit KCNQ4 that is encoded in the genome of mouse." [OMA:Q9JK97, PRO:DNx]

Yes

sequence



PR:000000918

voltage-gated potassium channel subunit KCNQ4 isoform 1

KCNQ4/iso:1


"A voltage-gated potassium channel subunit KCNQ4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56696-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P56696-1

potassium voltage-gated channel subfamily KQT member 4 isoform 1 (human)

hKCNQ4/iso:1


"A voltage-gated potassium channel subunit KCNQ4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000919

voltage-gated potassium channel subunit KCNQ4 isoform 2

KCNQ4/iso:2


"A voltage-gated potassium channel subunit KCNQ4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P56696-2 or a 1:1 ortholog thereof." [PMID:10025409]


organism-sequence



PR:P56696-2

potassium voltage-gated channel subfamily KQT member 4 isoform 2 (human)

hKCNQ4/iso:2


"A voltage-gated potassium channel subunit KCNQ4 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P56696]


gene



PR:000000732

voltage-gated potassium channel subunit KCNQ5

KCNQ5


"A voltage-gated potassium channel subunit KQT that is a translation product of the human KCNQ5 gene or a 1:1 ortholog thereof. It contributes to M-type potassium currents. It is also inhibited by M1 muscarinic receptor activation." [PRO:CNA]


organism-gene



PR:Q9JK45

potassium voltage-gated channel subfamily KQT member 5 (mouse)

mKCNQ5


"A voltage-gated potassium channel subunit KCNQ5 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q9JK45-1

potassium voltage-gated channel subfamily KQT member 5 isoform 1 (mouse)

mKCNQ5/iso:1


"A voltage-gated potassium channel subunit KCNQ5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:Q9NR82

potassium voltage-gated channel subfamily KQT member 5 (human)

hKCNQ5


"A voltage-gated potassium channel subunit KCNQ5 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9NR82]


organism-sequence



PR:Q9NR82-1

potassium voltage-gated channel subfamily KQT member 5 isoform 1 (human)

hKCNQ5/iso:1


"A voltage-gated potassium channel subunit KCNQ5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q9NR82-2

potassium voltage-gated channel subfamily KQT member 5 isoform 2 (human)

hKCNQ5/iso:2


"A voltage-gated potassium channel subunit KCNQ5 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q9NR82-3

potassium voltage-gated channel subfamily KQT member 5 isoform 3 (human)

hKCNQ5/iso:3


"A voltage-gated potassium channel subunit KCNQ5 isoform 3 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q9NR82-4

potassium voltage-gated channel subfamily KQT member 5 isoform 4 (human)

hKCNQ5/iso:4


"A voltage-gated potassium channel subunit KCNQ5 isoform 4 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9NR82-5

potassium voltage-gated channel subfamily KQT member 5 isoform h5 (human)

hKCNQ5/iso:h5


"A potassium voltage-gated channel subfamily KQT member 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR82-5." [PRO:DNx, UniProtKB:Q9NR82]


organism-sequence



PR:Q9NR82-6

potassium voltage-gated channel subfamily KQT member 5 isoform h6 (human)

hKCNQ5/iso:h6


"A potassium voltage-gated channel subfamily KQT member 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR82-6." [PRO:DNx, UniProtKB:Q9NR82]


organism-sequence



PR:Q9NR82-7

potassium voltage-gated channel subfamily KQT member 5 isoform h7 (human)

hKCNQ5/iso:h7


"A potassium voltage-gated channel subfamily KQT member 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR82-7." [PRO:DNx, UniProtKB:Q9NR82]


sequence



PR:000000926

voltage-gated potassium channel subunit KCNQ5 isoform 1

KCNQ5/iso:1


"A voltage-gated potassium channel subunit KCNQ5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR82-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q9JK45-1

potassium voltage-gated channel subfamily KQT member 5 isoform 1 (mouse)

mKCNQ5/iso:1


"A voltage-gated potassium channel subunit KCNQ5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q9NR82-1

potassium voltage-gated channel subfamily KQT member 5 isoform 1 (human)

hKCNQ5/iso:1


"A voltage-gated potassium channel subunit KCNQ5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000927

voltage-gated potassium channel subunit KCNQ5 isoform 2

KCNQ5/iso:2


"A voltage-gated potassium channel subunit KCNQ5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR82-2 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q9NR82-2

potassium voltage-gated channel subfamily KQT member 5 isoform 2 (human)

hKCNQ5/iso:2


"A voltage-gated potassium channel subunit KCNQ5 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000928

voltage-gated potassium channel subunit KCNQ5 isoform 3

KCNQ5/iso:3


"A voltage-gated potassium channel subunit KCNQ5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR82-3 or a 1:1 ortholog thereof. This isoform displays altered gating kinetics." [PMID:10816588, PRO:CNA]


organism-sequence



PR:Q9NR82-3

potassium voltage-gated channel subfamily KQT member 5 isoform 3 (human)

hKCNQ5/iso:3


"A voltage-gated potassium channel subunit KCNQ5 isoform 3 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000929

voltage-gated potassium channel subunit KCNQ5 isoform 4

KCNQ5/iso:4


"A voltage-gated potassium channel subunit KCNQ5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9NR82-4 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9NR82-4

potassium voltage-gated channel subfamily KQT member 5 isoform 4 (human)

hKCNQ5/iso:4


"A voltage-gated potassium channel subunit KCNQ5 isoform 4 that is encoded in the genome of human." [PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000684 fam:Kchan_sub-KQT
KQT channels are responsible for M-type potassium currents in the nervous and auditory systems and slow delayed rectifier K+ currents in the heart
enablescontributes_to GO:0005249 voltage-gated potassium channel activity PIRSF:PIRSF038513
located_inGO:0008076 voltage-gated potassium channel complex PIRSF:PIRSF038513
PR:000000817 hKCNQ1/var:T587M
Example: UniProtKB:P51787-1, Thr-587, CHEBI:16044
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10024302; PMID:10704188
PR:000000818 hKCNQ1/var:S373P
Example: UniProtKB:P51787-1, Ser-373, CHEBI:50342
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10220144; PMID:10704188
PR:000000819 hKCNQ1/var:R243C
Example: UniProtKB:P51787-1, Arg-243, CHEBI:29950
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10409658; PMID:10704188
enablesaltered GO:0005251 delayed rectifier potassium channel activity relative to PR:000002622 KCNQ1/iso:1/UnMod PMID:10409658
PR:000000820 hKCNQ1/var:D317N
Example: UniProtKB:P51787-1, Asp-317, CHEBI:50347
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9302275; PMID:9482580
PR:000000821 hKCNQ1/var:V310I
Example: UniProtKB:P51787-1, Val-310, CHEBI:30009
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000822 hKCNQ1/var:S566F
Example: UniProtKB:P51787-1, Ser-566, CHEBI:29997
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000823 hKCNQ1/var:Y315C
Example: UniProtKB:P51787-1, Tyr-315, CHEBI:29950
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9693036; PMID:9927399
PR:000000824 hKCNQ1/var:S225L
Example: UniProtKB:P51787-1, Ser-225, CHEBI:30006
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9927399
PR:000000825 hKCNQ1/var:A178P
Example: UniProtKB:P51787-1, Ala-178, CHEBI:50342
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9323054
enablesNOT|contributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10704188; PMID:9323054
located_inSO:0001559 polypeptide_loss_of_function_variant PMID:9323054
PR:000000826 hKCNQ1/var:A178T
Example: UniProtKB:P51787-1, Ala-178, CHEBI:30013
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9024139
PR:000000827 hKCNQ1/var:G189R
Example: UniProtKB:P51787-1, Gly-189, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10220144; PMID:10704188
PR:000000828 hKCNQ1/var:P448R
Example: UniProtKB:P51787-1, Pro-448, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000829 hKCNQ1/var:T309R
Example: UniProtKB:P51787-1, Thr-309, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000830 hKCNQ1/var:R591H
Example: UniProtKB:P51787-1, Arg-591, CHEBI:29979
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10024302; PMID:10704188
PR:000000831 hKCNQ1/var:R366W
Example: UniProtKB:P51787-1, Arg-366, CHEBI:29954
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9693036
PR:000000832 hKCNQ1/var:I313M
Example: UniProtKB:P51787-1, Ile-313, CHEBI:16044
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9024139
PR:000000833 hKCNQ1/var:Y111C
Example: UniProtKB:P51787-1, Tyr-111, CHEBI:29950
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000834 hKCNQ1/var:R533W
Example: UniProtKB:P51787-1, Arg-533, CHEBI:29954
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:10728423
enablesaltered GO:0005251 delayed rectifier potassium channel activity relative to PR:000002622 KCNQ1/iso:1/UnMod PMID:10704188; PMID:10728423
PR:000000835 hKCNQ1/var:G168R
Example: UniProtKB:P51787-1, Gly-168, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:9693036
PR:000000836 hKCNQ1/var:E261D
Example: UniProtKB:P51787-1, Glu-261, CHEBI:29958
associated_with_disease_progressionDO:2842 Jervell-Lange Nielsen syndrome PMID:10704188
PR:000000837 hKCNQ1/var:A371T
Example: UniProtKB:P51787-1, Ala-371, CHEBI:30013
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000838 hKCNQ1/var:29
Example: UniProtKB:P49747-1, 21-70, 74-757
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10511610
PR:000000839 hKCNQ1/var:A341V
Example: UniProtKB:P51787-1, Ala-341, CHEBI:30015
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:8818942; PMID:8872472; PMID:9570196
PR:000000840 hKCNQ1/var:L250H
Example: UniProtKB:P51787-1, Leu-250, CHEBI:29979
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000841 hKCNQ1/var:S349W
Example: UniProtKB:P51787-1, Ser-349, CHEBI:29954
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000842 hKCNQ1/var:T391I
Example: UniProtKB:P51787-1, Thr-391, CHEBI:30009
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000843 hKCNQ1/var:K318N
Example: UniProtKB:P51787-1, Lys-318, CHEBI:50347
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9693036
PR:000000844 hKCNQ1/var:A344V
Example: UniProtKB:P51787-1, Ala-344, CHEBI:30015
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000845 hKCNQ1/var:A525T
Example: UniProtKB:P51787-1, Ala-525, CHEBI:30013
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10482963; PMID:10704188
PR:000000846 hKCNQ1/var:A341E
Example: UniProtKB:P51787-1, Ala-341, CHEBI:29972
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
MP:0003233 prolonged QT interval PMID:15498462
PR:000000847 hKCNQ1/var:R583C
Example: UniProtKB:P51787-1, Arg-583, CHEBI:29950
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000848 hKCNQ1/var:D242N
Example: UniProtKB:P51787-1, Asp-242, CHEBI:50347
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000849 hKCNQ1/var:L342F
Example: UniProtKB:P51787-1, Leu-342, CHEBI:29997
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000850 hKCNQ1/var:G306R
Example: UniProtKB:P51787-1, Gly-306, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000851 hKCNQ1/var:S140G
Example: UniProtKB:P51787-1, Ser-140, CHEBI:29947
associated_with_disease_progressionDO:0050650 familial atrial fibrillation PMID:12522251
enablesincreased GO:0005267 potassium channel activity relative to PR:000002622 KCNQ1/iso:1/UnMod PMID:12522251
located_inSO:0001557 polypeptide_gain_of_function_variant PMID:12522251
PR:000000852 hKCNQ1/var:G269S
Example: UniProtKB:P51787-1, Gly-269, CHEBI:29999
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000853 hKCNQ1/var:R555C
Example: UniProtKB:P51787-1, Arg-555, CHEBI:29950
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000854 hKCNQ1/var:R539W
Example: UniProtKB:P51787-1, Arg-539, CHEBI:29954
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10728423
enablesaltered GO:0005251 delayed rectifier potassium channel activity relative to PR:000002622 KCNQ1/iso:1/UnMod PMID:10728423
located_inaltered GO:0008076 voltage-gated potassium channel complex relative to PR:000002622 KCNQ1/iso:1/UnMod PMID:10728423
PR:000000855 hKCNQ1/var:Y315S
Example: UniProtKB:P51787-1, Tyr-315, CHEBI:29999
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10220144; PMID:10704188
PR:000000856 hKCNQ1/var:R174H
Example: UniProtKB:P51787-1, Arg-174, CHEBI:29979
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10367071
PR:000000857 hKCNQ1/var:A194P
Example: UniProtKB:P51787-1, Ala-194, CHEBI:50342
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000858 hKCNQ1/var:Y184S
Example: UniProtKB:P51787-1, Tyr-184, CHEBI:29999
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10220144
PR:000000859 hKCNQ1/var:G345E
Example: UniProtKB:P51787-1, Gly-345, CHEBI:29972
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000860 hKCNQ1/var:R190Q
Example: UniProtKB:P51787-1, Arg-190, CHEBI:30011
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:10728423
enablesNOT|contributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10728423
located_inNOT GO:0008076 voltage-gated potassium channel complex PMID:10728423
SO:0001559 polypeptide_loss_of_function_variant PMID:10704188; PMID:9482580
PR:000000861 hKCNQ1/var:T311I
Example: UniProtKB:P51787-1, Thr-311, CHEBI:30009
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9482580
PR:000000862 hKCNQ1/var:G314S
Example: UniProtKB:P51787-1, Gly-314, CHEBI:29999
associated_with_disease_progressionDO:2843 long QT syndrome PMID:8872472; PMID:9693036
PR:000000863 hKCNQ1/var:W248R
Example: UniProtKB:P51787-1, Trp-248, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10409658
enablesaltered|contributes_to GO:0005251 delayed rectifier potassium channel activity relative to PR:000002622 KCNQ1/iso:1/UnMod PMID:10409658
located_inGO:0008076 voltage-gated potassium channel complex PMID:10728423
SO:0001561 polypeptide_partial_loss_of_function PMID:10409658
PR:000000864 hKCNQ1/var:R366P
Example: UniProtKB:P51787-1, Arg-366, CHEBI:50342
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188; PMID:9024139
PR:000000865 hKCNQ1/var:R366Q
Example: UniProtKB:P51787-1, Arg-366, CHEBI:30011
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000866 hKCNQ1/var:E160K
Example: UniProtKB:P51787-1, Glu-160, CHEBI:29967
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000867 hKCNQ1/var:V254M
Example: UniProtKB:P51787-1, Val-254, CHEBI:16044
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000868 hKCNQ1/var:G345R
Example: UniProtKB:P51787-1, Gly-345, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10220144
PR:000000869 hKCNQ1/var:E261K
Example: UniProtKB:P51787-1, Glu-261, CHEBI:29967
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10409658
enablesNOT|contributes_to GO:0005251 delayed rectifier potassium channel activity PMID:8900283
located_inNOT GO:0008076 voltage-gated potassium channel complex PMID:8900283
PR:000000870 hKCNQ1/var:V307L
Example: UniProtKB:P51787-1, Val-307, CHEBI:30006
associated_with_disease_progressionDO:0050793 short QT syndrome PMID:15159330
enablesincreased GO:0005267 potassium channel activity relative to PR:000002622 KCNQ1/iso:1/UnMod PMID:15159330
located_inSO:0001557 polypeptide_gain_of_function_variant PMID:15159330
PR:000000871 hKCNQ1/var:F339del
Example: UniProtKB:P49747-1, 21-338, 340-757
associated_with_disease_progressionDO:2843 long QT syndrome PMID:15159330
PR:000000872 hKCNQ1/var:R243H
Example: UniProtKB:P51787-1, Arg-243, CHEBI:29979
associated_with_disease_progressionDO:2842 Jervell-Lange Nielsen syndrome PMID:10728423
enablesdecreased|contributes_to GO:0005251 delayed rectifier potassium channel activity relative to PR:000002622 KCNQ1/iso:1/UnMod PMID:10728423
located_inGO:0008076 voltage-gated potassium channel complex PMID:10728423
PR:000000873 hKCNQ1/var:G179S
Example: UniProtKB:P51787-1, Gly-179, CHEBI:29999
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10728423
PR:000000874 hKCNQ1/var:A300T
Example: UniProtKB:P51787-1, Ala-300, CHEBI:30013
associated_with_disease_progressionDO:2843 long QT syndrome PMID:9641694
enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9641694
PR:000000875 hKCNQ1/var:R174C
Example: UniProtKB:P51787-1, Arg-174, CHEBI:29950
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000876 hKCNQ1/var:W305S
Example: UniProtKB:P51787-1, Trp-305, CHEBI:29999
associated_with_disease_progressionDO:2842 Jervell-Lange Nielsen syndrome PMID:9781056
PR:000000877 hKCNQ1/var:L266P
Example: UniProtKB:P51787-1, Leu-266, CHEBI:50342
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000878 hKCNQ1/var:R594Q
Example: UniProtKB:P51787-1, Arg-594, CHEBI:30011
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000879 hKCNQ1/var:L273F
Example: UniProtKB:P51787-1, Leu-273, CHEBI:29997
associated_with_disease_progressionDO:2843 long QT syndrome PMID:9323054
enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9323054
located_inSO:0001561 polypeptide_partial_loss_of_function PMID:9323054
PR:000000880 hKCNQ1/var:Y281C
Example: UniProtKB:P51787-1, Tyr-281, CHEBI:29950
associated_with_disease_progressionDO:2843 long QT syndrome PMID:9927399
PR:000000881 hKCNQ1/var:P320A
Example: UniProtKB:P51787-1, Pro-320, CHEBI:46217
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000882 hKCNQ1/var:F157C
Example: UniProtKB:P51787-1, Phe-157, CHEBI:29950
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10220146
PR:000000883 hKCNQ1/var:L353P
Example: UniProtKB:P51787-1, Leu-353, CHEBI:50342
associated_with_disease_progressionDO:2843 long QT syndrome PMID:9693036
PR:000000884 hKCNQ1/var:G325R
Example: UniProtKB:P51787-1, Gly-325, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:9024139
PR:000000885 hKCNQ1/var:W392R
Example: UniProtKB:P51787-1, Trp-392, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10220144
PR:000000886 hKCNQ1/var:G269D
Example: UniProtKB:P51787-1, Gly-269, CHEBI:29958
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000887 hKCNQ1/var:G589D
Example: UniProtKB:P51787-1, Gly-589, CHEBI:29958
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000888 hKCNQ1/var:G216R
Example: UniProtKB:P51787-1, Gly-216, CHEBI:29952
associated_with_disease_progressionDO:2843 long QT syndrome PMID:9272155
PR:000000889 hKCNQ1/var:V417M
Example: UniProtKB:P51787-1, Val-417, CHEBI:16044
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10704188
PR:000000890 hKCNQ1/var:T312I
Example: UniProtKB:P51787-1, Thr-312, CHEBI:30009
associated_with_disease_progressionDO:2843 long QT syndrome PMID:10409658; PMID:9323054
enablesNOT|contributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10409658; PMID:9323054
located_inSO:0001559 polypeptide_loss_of_function_variant PMID:10409658; PMID:9323054
PR:000000907 hKCNQ2/var:S247W
Example: UniProtKB:O43526-1, Ser-247, CHEBI:29954
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:12742592
enablesdecreased GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:12742592
PR:000000908 hKCNQ2/var:H228Q
Example: UniProtKB:O43526-1, His-228, CHEBI:30011
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000909 hKCNQ2/var:R207W
Example: UniProtKB:O43526-1, Arg-207, CHEBI:29954
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:11572947
enablesdecreased GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:11572947
PR:000000910 hKCNQ2/var:L243F
Example: UniProtKB:O43526-1, Leu-243, CHEBI:29997
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000911 hKCNQ2/var:4
Example: UniProtKB:O43526-1, Arg-214, CHEBI:29954
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:11175290
PR:000000912 hKCNQ2/var:Y284C
Example: UniProtKB:O43526-1, Tyr-284, CHEBI:29950
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:10788442
located_inGO:0009986 cell surface PMID:10788442
PR:000000913 hKCNQ2/var:A306T
Example: UniProtKB:O43526-1, Ala-306, CHEBI:30013
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:10788442
located_inGO:0009986 cell surface PMID:10788442
PR:000000914 hKCNQ2/var:R333Q
Example: UniProtKB:O43526-1, Arg-333, CHEBI:30011
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000915 hKCNQ2/var:M208V
Example: UniProtKB:O43526-1, Met-208, CHEBI:30015
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:14534157
PR:000000916 hKCNQ2/iso:3/var:K526N
UniProtKB:O43526-3, Lys-526, CHEBI:50347
associated_with_disease_progressionDO:14264 benign neonatal seizures PMID:15249611
PR:000000920 hKCNQ4/var:G285C
Example: UniProtKB:P56696-1, Gly-285, CHEBI:29950
associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10369879
enablesaltered GO:0005249 voltage-gated potassium channel activity relative to PR:000000918 KCNQ4/iso:1 PMID:10369879
PR:000000921 hKCNQ4/var:L274H
Example: UniProtKB:P56696-1, Leu-274, CHEBI:29979
associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10925378
PR:000000922 hKCNQ4/var:G285S
Example: UniProtKB:P56696-1, Gly-285, CHEBI:29999
associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10025409
enablesaltered GO:0005249 voltage-gated potassium channel activity relative to PR:000000918 KCNQ4/iso:1 PMID:10025409
PR:000000923 hKCNQ4/var:L281S
Example: UniProtKB:P56696-1, Leu-281, CHEBI:29999
associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10571947
PR:000000924 hKCNQ4/var:W276S
Example: UniProtKB:P56696-1, Trp-276, CHEBI:29999
associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10369879
PR:000000925 hKCNQ4/var:G321S
Example: UniProtKB:P56696-1, Gly-321, CHEBI:29999
associated_with_disease_progressionDO:0050564 autosomal dominant nonsyndromic deafness PMID:10369879
PR:O43525 hKCNQ3 acts_upstream_of_or_withinGO:0006813 potassium ion transport PMID:9677360
GO:0007268 chemical synaptic transmission PMID:9425900
PR:O43526-2 hKCNQ2/iso:2 enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:11160379
PR:O43526-4 hKCNQ2/iso:4 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9836639
PR:O43526-6 hKCNQ2/iso:6 enablesdecreased|contributes_to GO:0005249 voltage-gated potassium channel activity relative to PR:000002632 KCNQ2/iso:2/UnMod PMID:9039501
PR:O88943-1 rKCNQ2/iso:A enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:11038262
PR:P51787-1 hKCNQ1/iso:1 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:9312006
PR:P51787-2 hKCNQ1/iso:2 enablescontributes_to GO:0043267 negative regulation of potassium ion transport PMID:9305853
PR:Q9JK45-1 mKCNQ5/iso:1 acts_upstream_of_or_withinGO:0006813 potassium ion transport PMID:15963599
enablesGO:0005249 voltage-gated potassium channel activity PMID:15963599
PR:Q9JK97 mKCNQ4 acts_upstream_of_or_withinGO:0007605 sensory perception of sound PMID:16437162
GO:0042472 inner ear morphogenesis PMID:16437162
PR:Q9NR82-1 hKCNQ5/iso:1 acts_upstream_of_or_withinGO:0007268 chemical synaptic transmission PMID:10787416
located_inGO:0008076 voltage-gated potassium channel complex PMID:10787416
PR:Q9NR82-2 hKCNQ5/iso:2 enablesGO:0005249 voltage-gated potassium channel activity PMID:10816588
PR:Q9NR82-3 hKCNQ5/iso:3 enablesGO:0005249 voltage-gated potassium channel activity PMID:10816588
PR:Q9Z351-10 mKCNQ2/iso:10 enablesNOT GO:0022832 voltage-gated channel activity PMID:9666519
PR:Q9Z351-11 mKCNQ2/iso:11 enablesNOT GO:0022832 voltage-gated channel activity PMID:9666519
PR:Q9Z351-12 mKCNQ2/iso:12 enablesGO:0005516 calmodulin binding PMID:12223552
located_inGO:0008076 voltage-gated potassium channel complex PMID:12223552
GO:0009986 cell surface PMID:12223552
PR:Q9Z351-9 mKCNQ2/iso:9 enablesNOT GO:0022832 voltage-gated channel activity PMID:9666519