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Protein Ontology report - cyclic nucleotide-gated channel alpha-1
PR:000000686 - http://purl.obolibrary.org/obo/PR_000000686
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000686   
  PRO namecyclic nucleotide-gated channel alpha-1 
  Synonyms
PRO-Short-label: EXACT:CNGA1
Gene-based: RELATED:CNCG | CNCG1
Other: EXACT:cGMP-gated cation channel alpha-1 | CNG channel alpha-1 | CNG-1 | CNG1 | cyclic nucleotide-gated cation channel 1 | cyclic nucleotide-gated channel, photoreceptor | rod photoreceptor cGMP-gated cation channel subunit alpha | rod photoreceptor cGMP-gated channel subunit alpha
  Definition"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA1 gene or a 1:1 ortholog thereof. In the retina, these proteins can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000673 cyclic nucleotide-gated channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:394
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000686

cyclic nucleotide-gated channel alpha-1

CNGA1


"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA1 gene or a 1:1 ortholog thereof. In the retina, these proteins can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors." [PRO:CNA]


organism-gene



PR:P29973

cyclic nucleotide-gated channel alpha-1 (human)

hCNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P29973]


organism-sequence



PR:000000738

cyclic nucleotide-gated channel alpha-1 sequence variant S320F (human)

hCNGA1/var:S320F


"A cyclic nucleotide-gated channel alpha-1 (human) that has a Phe residue at the position equivalent to Ser-320 of the amino acid sequence represented by UniProtKB:P29973-1. Example: UniProtKB:P29973-1, Ser-320, CHEBI:29997." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P29973-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (human)

hCNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000078527

cyclic nucleotide-gated channel alpha-1 deaminated 1 (human)

hCNGA1/Deam:1


"A cyclic nucleotide-gated channel alpha-1 (human) that has been deaminated on the residue at the position equivalent to Asn-159 of the amino acid sequence represented by UniProtKB:P29973. UniProtKB:P29973, Asn-159, MOD:00684." [IEDB_epitope:1327288, PRO:DNx]


organism-gene



PR:P29974

cyclic nucleotide-gated channel alpha-1 (mouse)

mCNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of mouse." [OMA:P29974, PRO:DNx]

Yes

organism-sequence



PR:P29974-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (mouse)

mCNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q00194

cyclic nucleotide-gated channel alpha-1 (cow)

cow-CNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of cow." [OMA:Q00194, PRO:DNx]


organism-sequence



PR:Q00194-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (cow)

cow-CNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of cow." [PRO:CNA]

Yes

organism-modification



PR:000036569

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)

cow-CNGA1/iso:1/Phos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]

Yes

organism-modification



PR:000045379

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)

cow-CNGA1/iso:1/Phos:2


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]


organism-modification



PR:000045381

cyclic nucleotide-gated channel alpha-1 isoform 1 unphosphorylated 1 (cow)

cow-CNGA1/iso:1/UnPhos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 (cow) that lacks phosphorylation on Tyr-498. UniProtKB:Q00194-1, Tyr-498, PR:000026291." [PMID:10366613, PRO:CNA]

Yes

organism-gene



PR:Q62927

cyclic nucleotide-gated channel alpha-1 (rat)

rCNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of rat." [OMA:Q62927, PRO:DNx]


organism-gene



PR:Q90980

cyclic nucleotide-gated channel rod photoreceptor subunit alpha (chicken)

chick-CNGA1


"A cyclic nucleotide-gated channel alpha-1 that is encoded in the genome of chicken." [OMA:Q90980, PRO:DNx]


sequence



PR:000000737

cyclic nucleotide-gated channel alpha-1 isoform 1

CNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P29973-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P29973-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (human)

hCNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:P29974-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (mouse)

mCNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q00194-1

cyclic nucleotide-gated channel alpha-1 isoform 1 (cow)

cow-CNGA1/iso:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that is encoded in the genome of cow." [PRO:CNA]

Yes

organism-modification



PR:000036569

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)

cow-CNGA1/iso:1/Phos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]

Yes

organism-modification



PR:000045379

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)

cow-CNGA1/iso:1/Phos:2


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]


organism-modification



PR:000045381

cyclic nucleotide-gated channel alpha-1 isoform 1 unphosphorylated 1 (cow)

cow-CNGA1/iso:1/UnPhos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 (cow) that lacks phosphorylation on Tyr-498. UniProtKB:Q00194-1, Tyr-498, PR:000026291." [PMID:10366613, PRO:CNA]

Yes

modification



PR:000000932

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form

CNGA1/iso:1/PhosRes+


"A cyclic nucleotide-gated channel alpha-1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000981

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1

CNGA1/iso:1/Phos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB). Example: UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825]


organism-modification



PR:000036569

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 (cow)

cow-CNGA1/iso:1/Phos:1


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 1 in cow. UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825, PRO:CNA]

Yes

modification



PR:000045378

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2

CNGA1/iso:1/Phos:2


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB) and the residue at the position equivalent to Tyr-503 of the amino acid sequence represented by UniProtKB:Q00194-1. This phosphorylation prevents Ca2+/CaM inhibition of the CNG channel, but at the same time has a similar effect, that is decreases the apparent affinity for cGMP. Example: UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:23032687, PRO:CNA, PRO:DAN]


organism-modification



PR:000045379

cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 (cow)

cow-CNGA1/iso:1/Phos:2


"A cyclic nucleotide-gated channel alpha-1 isoform 1 phosphorylated 2 in cow. UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PMID:15381690, PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000738 hCNGA1/var:S320F
Example: UniProtKB:P29973-1, Ser-320, CHEBI:29997
associated_with_disease_progressionDO:10584 retinitis pigmentosa PMID:7479749
located_inNOT GO:0005886 plasma membrane PMID:7479749
PR:000036569 cow-CNGA1/iso:1/Phos:1
UniProtKB:Q00194-1, Tyr-498, MOD:00048
enablesdecreased GO:0030553 cGMP binding relative to PR:000002593 PMID:10366613
PR:000045381 cow-CNGA1/iso:1/UnPhos:1
UniProtKB:Q00194-1, Tyr-498, PR:000026291
enablesGO:0030553 cGMP binding PMID:10366613
PR:P29973-1 hCNGA1/iso:1 located_inGO:0005886 plasma membrane PMID:7479749
PR:P29974 mCNGA1 located_inGO:0001750 photoreceptor outer segment PMID:15634774
PR:Q00194-1 cow-CNGA1/iso:1 located_inGO:0017071 intracellular cyclic nucleotide activated cation channel complex PMID:12432397; PMID:12467591