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Protein Ontology report - cyclic nucleotide-gated channel alpha-3
PR:000000696 - http://purl.obolibrary.org/obo/PR_000000696
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000696   
  PRO namecyclic nucleotide-gated channel alpha-3 
  Synonyms
PRO-Short-label: EXACT:CNGA3
Gene-based: RELATED:CNCG3
Other: EXACT:CNG channel alpha-3 | CNG-3 | CNG3 | cone photoreceptor cGMP-gated channel subunit alpha | cone photoreceptor cGMP-gated channel subunit alpha-3 | cyclic nucleotide-gated cation channel alpha-3
  Definition"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA3 gene or a 1:1 ortholog thereof. These proteins are the alpha subunits of the cone cyclic nucleotide-gated cation channel. This channel generates the light-evoked electrical responses of cone photoreceptors." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000673 cyclic nucleotide-gated channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence2                                                  Organism-Sequence 14                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:396
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000696 cyclic nucleotide-gated channel alpha-3
CNGA3

organism-gene


PR:Q16281 cyclic nucleotide-gated channel alpha-3 (human)
hCNGA3

organism-sequence


PR:000000741 cyclic nucleotide-gated channel alpha-3 sequence variant R283Q (human)
hCNGA3/var:R283Q
Yes
organism-sequence


PR:000000742 cyclic nucleotide-gated channel alpha-3 sequence variant T291R (human)
hCNGA3/var:T291R
Yes
organism-sequence


PR:000000743 cyclic nucleotide-gated channel alpha-3 sequence variant G557R (human)
hCNGA3/var:G557R
Yes
organism-sequence


PR:000000744 cyclic nucleotide-gated channel alpha-3 sequence variant V529M (human)
hCNGA3/var:V529M
Yes
organism-sequence


PR:000000745 cyclic nucleotide-gated channel alpha-3 sequence variant R283W (human)
hCNGA3/var:R283W
Yes
organism-sequence


PR:000000746 cyclic nucleotide-gated channel alpha-3 sequence variant F547L (human)
hCNGA3/var:F547L
Yes
organism-sequence


PR:000000747 cyclic nucleotide-gated channel alpha-3 sequence variant R410W (human)
hCNGA3/var:R410W
Yes
organism-sequence


PR:000000748 cyclic nucleotide-gated channel alpha-3 sequence variant P163L (human)
hCNGA3/var:P163L
Yes
organism-sequence


PR:Q16281-1 cyclic nucleotide-gated channel alpha-3 isoform 1 (human)
hCNGA3/iso:1
Yes
organism-sequence


PR:Q16281-2 cyclic nucleotide-gated channel alpha-3 isoform h2 (human)
hCNGA3/iso:h2

organism-sequence


PR:Q16281-3 cyclic nucleotide-gated channel alpha-3 isoform h3 (human)
hCNGA3/iso:h3

organism-modification


PR:000081665 cyclic nucleotide-gated channel alpha-3 phosphorylated 1 (human)
hCNGA3/Phos:1

organism-gene


PR:Q90805 cyclic nucleotide-gated channel cone photoreceptor subunit alpha (chicken)
chick-CNGA3

organism-gene


PR:Q94A76 potassium channel GORK (Arabidopsis thaliana)
At-CNGA3

organism-gene


PR:Q9ER33 cyclic nucleotide-gated channel alpha-3 (rat)
rCNGA3

organism-sequence


PR:Q9ER33-1 cyclic nucleotide-gated channel alpha-3 isoform r1 (rat)
rCNGA3/iso:r1

organism-sequence


PR:Q9ER33-2 cyclic nucleotide-gated channel alpha-3 isoform r2 (rat)
rCNGA3/iso:r2

organism-gene


PR:Q9JJZ8 cyclic nucleotide-gated channel alpha-3 (mouse)
mCNGA3

organism-sequence


PR:Q9JJZ8-1 cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)
mCNGA3/iso:m1
Yes
sequence


PR:000000739 cyclic nucleotide-gated channel alpha-3 isoform 1
CNGA3/iso:1

organism-sequence


PR:Q16281-1 cyclic nucleotide-gated channel alpha-3 isoform 1 (human)
hCNGA3/iso:1
Yes
sequence


PR:000000740 cyclic nucleotide-gated channel alpha-3 isoform m1
CNGA3/iso:m1

organism-sequence


PR:Q9JJZ8-1 cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)
mCNGA3/iso:m1
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007165 signal transductionPR:Q16281-1 hCNGA3/iso:1 PMID:9517456

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:13911 achromatopsiaPR:000000741 hCNGA3/var:R283Q PMID:9662398
PR:000000742 hCNGA3/var:T291R PMID:9662398
PR:000000743 hCNGA3/var:G557R PMID:9662398
PR:000000744 hCNGA3/var:V529M PMID:9662398
PR:000000745 hCNGA3/var:R283W PMID:9662398
PR:000000746 hCNGA3/var:F547L PMID:9662398
PR:000000747 hCNGA3/var:R410W PMID:9662398
PR:000000748 hCNGA3/var:P163L PMID:9662398

Molecular Function GO Term
Protein Forms & Complexes
Evidence
contributes_to GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activityPR:Q9JJZ8-1 mCNGA3/iso:m1 PMID:10662822
GO:0015276 ligand-gated monoatomic ion channel activityPR:Q16281-1 hCNGA3/iso:1 PMID:9517456

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0001750 photoreceptor outer segmentPR:Q9JJZ8-1 mCNGA3/iso:m1 PMID:10813773; PMID:15634774
GO:0017071 intracellular cyclic nucleotide activated cation channel complexPR:Q16281-1 hCNGA3/iso:1 PMID:12467591
GO:0032991 protein-containing complexPR:Q9JJZ8-1 mCNGA3/iso:m1 PMID:10662822