back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - cyclic nucleotide-gated channel alpha-3
PR:000000696 - http://purl.obolibrary.org/obo/PR_000000696
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000696   
  PRO namecyclic nucleotide-gated channel alpha-3 
  Synonyms
PRO-Short-label: EXACT:CNGA3
Gene-based: RELATED:CNCG3
Other: EXACT:CNG channel alpha-3 | CNG-3 | CNG3 | cone photoreceptor cGMP-gated channel subunit alpha | cone photoreceptor cGMP-gated channel subunit alpha-3 | cyclic nucleotide-gated cation channel alpha-3
  Definition"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA3 gene or a 1:1 ortholog thereof. These proteins are the alpha subunits of the cone cyclic nucleotide-gated cation channel. This channel generates the light-evoked electrical responses of cone photoreceptors." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000673 cyclic nucleotide-gated channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence2                                                  Organism-Sequence 14                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
IUPHARobj:396
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000696

cyclic nucleotide-gated channel alpha-3

CNGA3


"A cyclic nucleotide-gated channel alpha subunit that is a translation product of the human CNGA3 gene or a 1:1 ortholog thereof. These proteins are the alpha subunits of the cone cyclic nucleotide-gated cation channel. This channel generates the light-evoked electrical responses of cone photoreceptors." [PRO:CNA]


organism-gene



PR:Q16281

cyclic nucleotide-gated channel alpha-3 (human)

hCNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q16281]


organism-sequence



PR:000000741

cyclic nucleotide-gated channel alpha-3 sequence variant R283Q (human)

hCNGA3/var:R283Q


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Gln residue at the position equivalent to Arg-283 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-283, CHEBI:30011." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000742

cyclic nucleotide-gated channel alpha-3 sequence variant T291R (human)

hCNGA3/var:T291R


"A cyclic nucleotide-gated channel alpha-3 (human) that has an Arg residue at the position equivalent to Thr-291 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Thr-291, CHEBI:29952." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000743

cyclic nucleotide-gated channel alpha-3 sequence variant G557R (human)

hCNGA3/var:G557R


"A cyclic nucleotide-gated channel alpha-3 (human) that has an Arg residue at the position equivalent to Gly-557 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Gly-557, CHEBI:29952." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000744

cyclic nucleotide-gated channel alpha-3 sequence variant V529M (human)

hCNGA3/var:V529M


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Met residue at the position equivalent to Val-529 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Val-529, CHEBI:16044." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000745

cyclic nucleotide-gated channel alpha-3 sequence variant R283W (human)

hCNGA3/var:R283W


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Trp residue at the position equivalent to Arg-283 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-283, CHEBI:29954." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000746

cyclic nucleotide-gated channel alpha-3 sequence variant F547L (human)

hCNGA3/var:F547L


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Leu residue at the position equivalent to Phe-547 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Phe-547, CHEBI:30006." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000747

cyclic nucleotide-gated channel alpha-3 sequence variant R410W (human)

hCNGA3/var:R410W


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Trp residue at the position equivalent to Arg-410 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Arg-410, CHEBI:29954." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000748

cyclic nucleotide-gated channel alpha-3 sequence variant P163L (human)

hCNGA3/var:P163L


"A cyclic nucleotide-gated channel alpha-3 (human) that has a Leu residue at the position equivalent to Pro-163 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Pro-163, CHEBI:30006." [PMID:9662398, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q16281-1

cyclic nucleotide-gated channel alpha-3 isoform 1 (human)

hCNGA3/iso:1


"A cyclic nucleotide-gated channel alpha-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q16281-2

cyclic nucleotide-gated channel alpha-3 isoform h2 (human)

hCNGA3/iso:h2


"A cyclic nucleotide-gated channel alpha-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16281-2." [PRO:DNx, UniProtKB:Q16281]


organism-sequence



PR:Q16281-3

cyclic nucleotide-gated channel alpha-3 isoform h3 (human)

hCNGA3/iso:h3


"A cyclic nucleotide-gated channel alpha-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16281-3." [PRO:DNx, UniProtKB:Q16281]


organism-modification



PR:000081665

cyclic nucleotide-gated channel alpha-3 phosphorylated 1 (human)

hCNGA3/Phos:1


"A cyclic nucleotide-gated channel alpha-3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-341 of the amino acid sequence represented by UniProtKB:Q16281-1. Example: UniProtKB:Q16281-1, Ser-341, MOD:00046." [IEDB_epitope:2147051, PRO:DNx]


organism-gene



PR:Q90805

cyclic nucleotide-gated channel cone photoreceptor subunit alpha (chicken)

chick-CNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of chicken." [PRO:DAN]


organism-gene



PR:Q94A76

potassium channel GORK (Arabidopsis thaliana)

At-CNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of Arabidopsis thaliana." [PRO:CNA]


organism-gene



PR:Q9ER33

cyclic nucleotide-gated channel alpha-3 (rat)

rCNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of rat." [OMA:Q9ER33, PRO:DNx]


organism-sequence



PR:Q9ER33-1

cyclic nucleotide-gated channel alpha-3 isoform r1 (rat)

rCNGA3/iso:r1


"A cyclic nucleotide-gated channel alpha-3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ER33-1." [PRO:DNx, UniProtKB:Q9ER33]


organism-sequence



PR:Q9ER33-2

cyclic nucleotide-gated channel alpha-3 isoform r2 (rat)

rCNGA3/iso:r2


"A cyclic nucleotide-gated channel alpha-3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9ER33-2." [PRO:DNx, UniProtKB:Q9ER33]


organism-gene



PR:Q9JJZ8

cyclic nucleotide-gated channel alpha-3 (mouse)

mCNGA3


"A cyclic nucleotide-gated channel alpha-3 that is encoded in the genome of mouse." [OMA:Q9JJZ8, PRO:DNx]


organism-sequence



PR:Q9JJZ8-1

cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)

mCNGA3/iso:m1


"A cyclic nucleotide-gated channel alpha-3 isoform m1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9JJZ8]

Yes

sequence



PR:000000739

cyclic nucleotide-gated channel alpha-3 isoform 1

CNGA3/iso:1


"A cyclic nucleotide-gated channel alpha-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16281-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q16281-1

cyclic nucleotide-gated channel alpha-3 isoform 1 (human)

hCNGA3/iso:1


"A cyclic nucleotide-gated channel alpha-3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000740

cyclic nucleotide-gated channel alpha-3 isoform m1

CNGA3/iso:m1


"A cyclic nucleotide-gated channel alpha-3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JJZ8-1 or a 1:1 ortholog thereof." [PMID:10813773, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9JJZ8-1

cyclic nucleotide-gated channel alpha-3 isoform m1 (mouse)

mCNGA3/iso:m1


"A cyclic nucleotide-gated channel alpha-3 isoform m1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q9JJZ8]

Yes

Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000741 hCNGA3/var:R283Q
Example: UniProtKB:Q16281-1, Arg-283, CHEBI:30011
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000742 hCNGA3/var:T291R
Example: UniProtKB:Q16281-1, Thr-291, CHEBI:29952
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000743 hCNGA3/var:G557R
Example: UniProtKB:Q16281-1, Gly-557, CHEBI:29952
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000744 hCNGA3/var:V529M
Example: UniProtKB:Q16281-1, Val-529, CHEBI:16044
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000745 hCNGA3/var:R283W
Example: UniProtKB:Q16281-1, Arg-283, CHEBI:29954
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000746 hCNGA3/var:F547L
Example: UniProtKB:Q16281-1, Phe-547, CHEBI:30006
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000747 hCNGA3/var:R410W
Example: UniProtKB:Q16281-1, Arg-410, CHEBI:29954
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:000000748 hCNGA3/var:P163L
Example: UniProtKB:Q16281-1, Pro-163, CHEBI:30006
associated_with_disease_progressionDO:13911 achromatopsia PMID:9662398
PR:Q16281-1 hCNGA3/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9517456
enablesGO:0015276 ligand-gated monoatomic ion channel activity PMID:9517456
located_inGO:0017071 intracellular cyclic nucleotide activated cation channel complex PMID:12467591
PR:Q9JJZ8-1 mCNGA3/iso:m1 enablescontributes_to GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity PMID:10662822
located_inGO:0001750 photoreceptor outer segment PMID:10813773; PMID:15634774
GO:0032991 protein-containing complex PMID:10662822