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Protein Ontology report - modulatory voltage-gated potassium channel subunit KCNG
PR:000000701 - http://purl.obolibrary.org/obo/PR_000000701
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000701   
  PRO namemodulatory voltage-gated potassium channel subunit KCNG 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_sub-KCNG
Other: RELATED:silent subunit
  Definition"A voltage-gated potassium channel alpha subunit that is a modulator of the shab-related potassium channels (Kv2). Similarly to KCNF1, KCNV and KCNS subunits, KCNG subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PxT. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PMID:9305895
  PRO Categoryfamily 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 11                                        
         Sequence5                                                  Organism-Sequence 10                                        
         Modification0                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500980
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000701

modulatory voltage-gated potassium channel subunit KCNG

fam:Kchan_sub-KCNG


"A voltage-gated potassium channel alpha subunit that is a modulator of the shab-related potassium channels (Kv2). Similarly to KCNF1, KCNV and KCNS subunits, KCNG subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PxT. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PMID:9305895]

Yes

gene



PR:000000787

voltage-gated potassium channel KCNG1

KCNG1


"A modulatory voltage-gated potassium channel subunit KCNG that is a translation product of the human KCNG1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:A2BDX4

voltage-gated potassium channel regulatory subunit KCNG1 (mouse)

mKCNG1


"A voltage-gated potassium channel KCNG1 that is encoded in the genome of mouse." [OMA:A2BDX4, PRO:DNx]


organism-gene



PR:D4AD53

voltage-gated potassium channel regulatory subunit KCNG1 (rat)

rKCNG1


"A voltage-gated potassium channel KCNG1 that is encoded in the genome of rat." [OMA:D4AD53, PRO:DNx]


organism-gene



PR:Q9UIX4

voltage-gated potassium channel regulatory subunit KCNG1 (human)

hKCNG1


"A voltage-gated potassium channel KCNG1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UIX4]


organism-sequence



PR:Q9UIX4-1

voltage-gated potassium channel regulatory subunit KCNG1 isoform 1 (human)

hKCNG1/iso:1


"A voltage-gated potassium channel KCNG1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9UIX4-2

voltage-gated potassium channel regulatory subunit KCNG1 isoform 2 (human)

hKCNG1/iso:2


"A voltage-gated potassium channel KCNG1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000950

voltage-gated potassium channel KCNG1 isoform 1

KCNG1/iso:1


"A voltage-gated potassium channel KCNG1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UIX4-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9UIX4-1

voltage-gated potassium channel regulatory subunit KCNG1 isoform 1 (human)

hKCNG1/iso:1


"A voltage-gated potassium channel KCNG1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000951

voltage-gated potassium channel KCNG1 isoform 2

KCNG1/iso:2


"A voltage-gated potassium channel KCNG1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UIX4-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9UIX4-2

voltage-gated potassium channel regulatory subunit KCNG1 isoform 2 (human)

hKCNG1/iso:2


"A voltage-gated potassium channel KCNG1 isoform 2 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000000788

voltage-gated potassium channel subfamily G member 3

KCNG3


"A modulatory voltage-gated potassium channel subunit KCNG that is a translation product of the human KCNG3 gene or a 1:1 ortholog thereof. It has to be associated with Kv2 subunits (PR:000000677) or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1." [PRO:CNA]


organism-gene



PR:P59053

voltage-gated potassium channel regulatory subunit KCNG3 (mouse)

mKCNG3


"A voltage-gated potassium channel subfamily G member 3 that is encoded in the genome of mouse." [OMA:P59053, PRO:DNx]


organism-sequence



PR:P59053-1

voltage-gated potassium channel regulatory subunit KCNG3 isoform 1 (mouse)

mKCNG3/iso:1


"A voltage-gated potassium channel subfamily G member 3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P59053]


organism-sequence



PR:P59053-2

voltage-gated potassium channel regulatory subunit KCNG3 isoform 2 (mouse)

mKCNG3/iso:2


"A voltage-gated potassium channel subfamily G member 3 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q8R523

voltage-gated potassium channel regulatory subunit KCNG3 (rat)

rKCNG3


"A voltage-gated potassium channel subfamily G member 3 that is encoded in the genome of rat." [OMA:Q8R523, PRO:DNx]


organism-sequence



PR:Q8R523-1

voltage-gated potassium channel regulatory subunit KCNG3 isoform 1 (rat)

rKCNG3/iso:1


"A voltage-gated potassium channel subfamily G member 3 isoform 1 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:Q8R523]

Yes

organism-sequence



PR:Q8R523-2

voltage-gated potassium channel regulatory subunit KCNG3 isoform 2 (rat)

rKCNG3/iso:2


"A voltage-gated potassium channel subfamily G member 3 isoform 2 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-gene



PR:Q8TAE7

voltage-gated potassium channel regulatory subunit KCNG3 (human)

hKCNG3


"A voltage-gated potassium channel subfamily G member 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8TAE7]


organism-sequence



PR:Q8TAE7-1

voltage-gated potassium channel regulatory subunit KCNG3 isoform 1 (human)

hKCNG3/iso:1


"A voltage-gated potassium channel subfamily G member 3 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8TAE7]

Yes

organism-sequence



PR:Q8TAE7-2

voltage-gated potassium channel regulatory subunit KCNG3 isoform 2 (human)

hKCNG3/iso:2


"A voltage-gated potassium channel subfamily G member 3 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000076129

voltage-gated potassium channel regulatory subunit KCNG3 phosphorylated 1 (human)

hKCNG3/Phos:1


"A voltage-gated potassium channel regulatory subunit KCNG3 (human) that has been phosphorylated on the residue at the position equivalent to Thr-406 of the amino acid sequence represented by UniProtKB:Q8TAE7-1. Example: UniProtKB:Q8TAE7-1, Thr-406, MOD:00047." [IEDB_epitope:2146639, PRO:DNx]


sequence



PR:000000952

voltage-gated potassium channel subfamily G member 3 isoform 1

KCNG3/iso:1


"A voltage-gated potassium channel subfamily G member 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TAE7-1 or a 1:1 ortholog thereof." [PMID:15046870, PRO:CNA, PRO:DAN]


organism-sequence



PR:P59053-1

voltage-gated potassium channel regulatory subunit KCNG3 isoform 1 (mouse)

mKCNG3/iso:1


"A voltage-gated potassium channel subfamily G member 3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:P59053]


organism-sequence



PR:Q8R523-1

voltage-gated potassium channel regulatory subunit KCNG3 isoform 1 (rat)

rKCNG3/iso:1


"A voltage-gated potassium channel subfamily G member 3 isoform 1 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:Q8R523]

Yes

organism-sequence



PR:Q8TAE7-1

voltage-gated potassium channel regulatory subunit KCNG3 isoform 1 (human)

hKCNG3/iso:1


"A voltage-gated potassium channel subfamily G member 3 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8TAE7]

Yes

sequence



PR:000000953

voltage-gated potassium channel subfamily G member 3 isoform 2

KCNG3/iso:2


"A voltage-gated potassium channel subfamily G member 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TAE7-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P59053-2

voltage-gated potassium channel regulatory subunit KCNG3 isoform 2 (mouse)

mKCNG3/iso:2


"A voltage-gated potassium channel subfamily G member 3 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q8R523-2

voltage-gated potassium channel regulatory subunit KCNG3 isoform 2 (rat)

rKCNG3/iso:2


"A voltage-gated potassium channel subfamily G member 3 isoform 2 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-sequence



PR:Q8TAE7-2

voltage-gated potassium channel regulatory subunit KCNG3 isoform 2 (human)

hKCNG3/iso:2


"A voltage-gated potassium channel subfamily G member 3 isoform 2 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000000789

voltage-gated potassium channel subfamily G member 4

KCNG4


"A modulatory voltage-gated potassium channel subunit KCNG that is a translation product of the human KCNG4 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q80XM3

voltage-gated potassium channel regulatory subunit KCNG4 (mouse)

mKCNG4


"A voltage-gated potassium channel subfamily G member 4 that is encoded in the genome of mouse." [OMA:Q80XM3, PRO:DNx]


organism-gene



PR:Q8TDN1

voltage-gated potassium channel regulatory subunit KCNG4 (human)

hKCNG4


"A voltage-gated potassium channel subfamily G member 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q8TDN1]


organism-sequence



PR:Q8TDN1-1

voltage-gated potassium channel regulatory subunit KCNG4 isoform 1 (human)

hKCNG4/iso:1


"A voltage-gated potassium channel subfamily G member 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q8TDN1-2

voltage-gated potassium channel regulatory subunit KCNG4 isoform h2 (human)

hKCNG4/iso:h2


"A voltage-gated potassium channel regulatory subunit KCNG4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TDN1-2." [PRO:DNx, UniProtKB:Q8TDN1]


sequence



PR:000000954

voltage-gated potassium channel subfamily G member 4 isoform 1

KCNG4/iso:1


"A voltage-gated potassium channel subfamily G member 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8TDN1-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q8TDN1-1

voltage-gated potassium channel regulatory subunit KCNG4 isoform 1 (human)

hKCNG4/iso:1


"A voltage-gated potassium channel subfamily G member 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000009259

voltage-gated potassium channel KCNG2

KCNG2


"A modulatory voltage-gated potassium channel subunit KCNG that is a translation product of the human KCNG2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O73606

voltage-gated potassium channel regulatory subunit KCNG2 (chicken)

chick-KCNG2


"A voltage-gated potassium channel KCNG2 that is encoded in the genome of chicken." [OMA:O73606, PRO:DNx]


organism-gene



PR:Q9QYU3

voltage-gated potassium channel regulatory subunit KCNG2 (rat)

rKCNG2


"A voltage-gated potassium channel KCNG2 that is encoded in the genome of rat." [OMA:Q9QYU3, PRO:DNx]


organism-gene



PR:Q9UJ96

voltage-gated potassium channel regulatory subunit KCNG2 (human)

hKCNG2


"A voltage-gated potassium channel KCNG2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UJ96]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000701 fam:Kchan_sub-KCNG
The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits
enablesGO:0015459 potassium channel regulator activity PIRSF:PIRSF500980
PR:Q8R523-1 rKCNG3/iso:1 acts_upstream_of_or_withinGO:0006813 potassium ion transport PMID:15046870
enablescontributes_to GO:0005249 voltage-gated potassium channel activity PMID:15046870
PR:Q8R523-2 rKCNG3/iso:2 acts_upstream_of_or_withinGO:0006813 potassium ion transport PMID:15046870
enablesGO:0005249 voltage-gated potassium channel activity PMID:15046870
PR:Q8TAE7-1 hKCNG3/iso:1 located_inGO:0005783 endoplasmic reticulum PMID:12060745
GO:0005886 plasma membrane PMID:12060745