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Protein Ontology report - modulatory voltage-gated potassium channel subunit KCNS
PR:000000702 - http://purl.obolibrary.org/obo/PR_000000702
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000702   
  PRO namemodulatory voltage-gated potassium channel subunit KCNS 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_sub-KCNS
Other: RELATED:silent subunit
  Definition"A voltage-gated potassium channel alpha subunit that is a modulator of the shab-related potassium channels (Kv2). Similarly to KCNF1, KCNV and KCNG subunits, KCNS subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIT. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PMID:12642579, PMID:9305895] 
  PRO Categoryfamily 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 9                                        
         Sequence3                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500981
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000702 modulatory voltage-gated potassium channel subunit KCNS
fam:Kchan_sub-KCNS
Yes
gene


PR:000000798 voltage-gated potassium channel KCNS1
KCNS1

organism-gene


PR:O35173 delayed-rectifier potassium channel regulatory subunit KCNS1 (mouse)
mKCNS1

organism-sequence


PR:O35173-1 potassium voltage-gated channel subfamily S member 1 isoform 1 (mouse)
mKCNS1/iso:1
Yes
organism-gene


PR:O88758 delayed-rectifier potassium channel regulatory subunit KCNS1 (rat)
rKCNS1

organism-gene


PR:Q96KK3 delayed-rectifier potassium channel regulatory subunit KCNS1 (human)
hKCNS1

organism-sequence


PR:Q96KK3-1 delayed-rectifier potassium channel regulatory subunit KCNS1 isoform 1 (human)
hKCNS1/iso:1
Yes
sequence


PR:000000969 voltage-gated potassium channel KCNS1 isoform 1
KCNS1/iso:1

organism-sequence


PR:O35173-1 potassium voltage-gated channel subfamily S member 1 isoform 1 (mouse)
mKCNS1/iso:1
Yes
organism-sequence


PR:Q96KK3-1 delayed-rectifier potassium channel regulatory subunit KCNS1 isoform 1 (human)
hKCNS1/iso:1
Yes
gene


PR:000000799 voltage-gated potassium channel KCNS2
KCNS2

organism-gene


PR:O35174 delayed-rectifier potassium channel regulatory subunit KCNS2 (mouse)
mKCNS2

organism-sequence


PR:O35174-1 potassium voltage-gated channel subfamily S member 2 isoform 1 (mouse)
mKCNS2/iso:1
Yes
organism-gene


PR:Q9ER26 delayed-rectifier potassium channel regulatory subunit KCNS2 (rat)
rKCNS2

organism-gene


PR:Q9ULS6 delayed-rectifier potassium channel regulatory subunit KCNS2 (human)
hKCNS2

organism-sequence


PR:Q9ULS6-1 delayed-rectifier potassium channel regulatory subunit KCNS2 isoform 1 (human)
hKCNS2/iso:1

sequence


PR:000000970 voltage-gated potassium channel KCNS2 isoform 1
KCNS2/iso:1

organism-sequence


PR:O35174-1 potassium voltage-gated channel subfamily S member 2 isoform 1 (mouse)
mKCNS2/iso:1
Yes
organism-sequence


PR:Q9ULS6-1 delayed-rectifier potassium channel regulatory subunit KCNS2 isoform 1 (human)
hKCNS2/iso:1

gene


PR:000000800 voltage-gated potassium channel KCNS3
KCNS3

organism-gene


PR:O88759 delayed-rectifier potassium channel regulatory subunit KCNS3 (rat)
rKCNS3

organism-sequence


PR:O88759-1 potassium voltage-gated channel subfamily S member 3 isoform 1 (rat)
rKCNS3/iso:1

organism-gene


PR:Q8BQZ8 delayed-rectifier potassium channel regulatory subunit KCNS3 (mouse)
mKCNS3

organism-sequence


PR:Q8BQZ8-1 potassium voltage-gated channel subfamily S member 3 isoform 1 (mouse)
mKCNS3/iso:1

organism-gene


PR:Q9BQ31 delayed-rectifier potassium channel regulatory subunit KCNS3 (human)
hKCNS3

organism-sequence


PR:Q9BQ31-1 delayed-rectifier potassium channel regulatory subunit KCNS3 isoform 1 (human)
hKCNS3/iso:1

sequence


PR:000042822 voltage-gated potassium channel KCNS3 isoform 1
KCNS3/iso:1

organism-sequence


PR:O88759-1 potassium voltage-gated channel subfamily S member 3 isoform 1 (rat)
rKCNS3/iso:1

organism-sequence


PR:Q8BQZ8-1 potassium voltage-gated channel subfamily S member 3 isoform 1 (mouse)
mKCNS3/iso:1

organism-sequence


PR:Q9BQ31-1 delayed-rectifier potassium channel regulatory subunit KCNS3 isoform 1 (human)
hKCNS3/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000702 fam:Kchan_sub-KCNS
The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits		 enablesGO:0015459 potassium channel regulator activity PIRSF:PIRSF500981
PR:O35173-1 mKCNS1/iso:1 enablesGO:0015459 potassium channel regulator activity PMID:9305895
PR:O35174-1 mKCNS2/iso:1 enablesGO:0015459 potassium channel regulator activity PMID:9305895
PR:Q96KK3-1 hKCNS1/iso:1 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10484328
GO:0015459 potassium channel regulator activity PMID:10484328
located_inGO:0005886 plasma membrane PMID:10484328