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Protein Ontology report - modulatory voltage-gated potassium channel subunit KCNS
PR:000000702 - http://purl.obolibrary.org/obo/PR_000000702
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000702   
  PRO namemodulatory voltage-gated potassium channel subunit KCNS 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_sub-KCNS
Other: RELATED:silent subunit
  Definition"A voltage-gated potassium channel alpha subunit that is a modulator of the shab-related potassium channels (Kv2). Similarly to KCNF1, KCNV and KCNG subunits, KCNS subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIT. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PMID:12642579, PMID:9305895
  PRO Categoryfamily 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 9                                        
         Sequence3                                                  Organism-Sequence 7                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500981
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000702

modulatory voltage-gated potassium channel subunit KCNS

fam:Kchan_sub-KCNS


"A voltage-gated potassium channel alpha subunit that is a modulator of the shab-related potassium channels (Kv2). Similarly to KCNF1, KCNV and KCNG subunits, KCNS subunits are not able to form functional channels on their own. Also in common with these modulatory subunits, it lacks the conserved PxP motif located in the distal part of S6. In this class the motif is PIT. The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits." [PMID:12642579, PMID:9305895]

Yes

gene



PR:000000798

voltage-gated potassium channel KCNS1

KCNS1


"A modulatory voltage-gated potassium channel subunit KCNS that is a translation product of the human KCNS1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O35173

delayed-rectifier potassium channel regulatory subunit KCNS1 (mouse)

mKCNS1


"A voltage-gated potassium channel KCNS1 that is encoded in the genome of mouse." [OMA:O35173, PRO:DNx]


organism-sequence



PR:O35173-1

potassium voltage-gated channel subfamily S member 1 isoform 1 (mouse)

mKCNS1/iso:1


"A voltage-gated potassium channel KCNS1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:O88758

delayed-rectifier potassium channel regulatory subunit KCNS1 (rat)

rKCNS1


"A voltage-gated potassium channel KCNS1 that is encoded in the genome of rat." [OMA:O88758, PRO:DNx]


organism-gene



PR:Q96KK3

delayed-rectifier potassium channel regulatory subunit KCNS1 (human)

hKCNS1


"A voltage-gated potassium channel KCNS1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96KK3]


organism-sequence



PR:Q96KK3-1

delayed-rectifier potassium channel regulatory subunit KCNS1 isoform 1 (human)

hKCNS1/iso:1


"A voltage-gated potassium channel KCNS1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000969

voltage-gated potassium channel KCNS1 isoform 1

KCNS1/iso:1


"A voltage-gated potassium channel KCNS1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96KK3-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O35173-1

potassium voltage-gated channel subfamily S member 1 isoform 1 (mouse)

mKCNS1/iso:1


"A voltage-gated potassium channel KCNS1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q96KK3-1

delayed-rectifier potassium channel regulatory subunit KCNS1 isoform 1 (human)

hKCNS1/iso:1


"A voltage-gated potassium channel KCNS1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

gene



PR:000000799

voltage-gated potassium channel KCNS2

KCNS2


"A modulatory voltage-gated potassium channel subunit KCNS that is a translation product of the human KCNS2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O35174

delayed-rectifier potassium channel regulatory subunit KCNS2 (mouse)

mKCNS2


"A voltage-gated potassium channel KCNS2 that is encoded in the genome of mouse." [OMA:O35174, PRO:DNx]


organism-sequence



PR:O35174-1

potassium voltage-gated channel subfamily S member 2 isoform 1 (mouse)

mKCNS2/iso:1


"A voltage-gated potassium channel KCNS2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:Q9ER26

delayed-rectifier potassium channel regulatory subunit KCNS2 (rat)

rKCNS2


"A voltage-gated potassium channel KCNS2 that is encoded in the genome of rat." [OMA:Q9ER26, PRO:DNx]


organism-gene



PR:Q9ULS6

delayed-rectifier potassium channel regulatory subunit KCNS2 (human)

hKCNS2


"A voltage-gated potassium channel KCNS2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9ULS6]


organism-sequence



PR:Q9ULS6-1

delayed-rectifier potassium channel regulatory subunit KCNS2 isoform 1 (human)

hKCNS2/iso:1


"A voltage-gated potassium channel KCNS2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


sequence



PR:000000970

voltage-gated potassium channel KCNS2 isoform 1

KCNS2/iso:1


"A voltage-gated potassium channel KCNS2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O35174-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O35174-1

potassium voltage-gated channel subfamily S member 2 isoform 1 (mouse)

mKCNS2/iso:1


"A voltage-gated potassium channel KCNS2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q9ULS6-1

delayed-rectifier potassium channel regulatory subunit KCNS2 isoform 1 (human)

hKCNS2/iso:1


"A voltage-gated potassium channel KCNS2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


gene



PR:000000800

voltage-gated potassium channel KCNS3

KCNS3


"A modulatory voltage-gated potassium channel subunit KCNS that is a translation product of the human KCNS3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O88759

delayed-rectifier potassium channel regulatory subunit KCNS3 (rat)

rKCNS3


"A voltage-gated potassium channel KCNS3 that is encoded in the genome of rat." [OMA:O88759, PRO:DNx]


organism-sequence



PR:O88759-1

potassium voltage-gated channel subfamily S member 3 isoform 1 (rat)

rKCNS3/iso:1


"A voltage-gated potassium channel KCNS3 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-gene



PR:Q8BQZ8

delayed-rectifier potassium channel regulatory subunit KCNS3 (mouse)

mKCNS3


"A voltage-gated potassium channel KCNS3 that is encoded in the genome of mouse." [OMA:Q8BQZ8, PRO:DNx]


organism-sequence



PR:Q8BQZ8-1

potassium voltage-gated channel subfamily S member 3 isoform 1 (mouse)

mKCNS3/iso:1


"A voltage-gated potassium channel KCNS3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-gene



PR:Q9BQ31

delayed-rectifier potassium channel regulatory subunit KCNS3 (human)

hKCNS3


"A voltage-gated potassium channel KCNS3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9BQ31]


organism-sequence



PR:Q9BQ31-1

delayed-rectifier potassium channel regulatory subunit KCNS3 isoform 1 (human)

hKCNS3/iso:1


"A voltage-gated potassium channel KCNS3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


sequence



PR:000042822

voltage-gated potassium channel KCNS3 isoform 1

KCNS3/iso:1


"A voltage-gated potassium channel KCNS3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9BQ31-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O88759-1

potassium voltage-gated channel subfamily S member 3 isoform 1 (rat)

rKCNS3/iso:1


"A voltage-gated potassium channel KCNS3 isoform 1 that is encoded in the genome of rat." [PRO:DNx]


organism-sequence



PR:Q8BQZ8-1

potassium voltage-gated channel subfamily S member 3 isoform 1 (mouse)

mKCNS3/iso:1


"A voltage-gated potassium channel KCNS3 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9BQ31-1

delayed-rectifier potassium channel regulatory subunit KCNS3 isoform 1 (human)

hKCNS3/iso:1


"A voltage-gated potassium channel KCNS3 isoform 1 that is encoded in the genome of human." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000702 fam:Kchan_sub-KCNS
The alteration of the PxP motif seems to be an important determinant of the regulatory function of modulatory subunits
enablesGO:0015459 potassium channel regulator activity PIRSF:PIRSF500981
PR:O35173-1 mKCNS1/iso:1 enablesGO:0015459 potassium channel regulator activity PMID:9305895
PR:O35174-1 mKCNS2/iso:1 enablesGO:0015459 potassium channel regulator activity PMID:9305895
PR:Q96KK3-1 hKCNS1/iso:1 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10484328
GO:0015459 potassium channel regulator activity PMID:10484328
located_inGO:0005886 plasma membrane PMID:10484328