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Protein Ontology report - platelet-derived growth factor C
PR:000000703 - http://purl.obolibrary.org/obo/PR_000000703
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000703   
  PRO nameplatelet-derived growth factor C 
  Synonyms
PRO-Short-label: EXACT:PDGFC
Gene-based: RELATED:SCDGF | UNQ174/PRO200
Other: EXACT:fallotein | PDGF-C | spinal cord-derived growth factor | VEGF-E
  Definition"A platelet-derived growth factor with CUB domain that is a translation product of the human PDGFC gene or a 1:1 ortholog thereof. Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000675 platelet-derived growth factor with CUB domain
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification5                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000703 platelet-derived growth factor C
PDGFC

organism-gene


PR:Q8CI19 platelet-derived growth factor C (mouse)
mPDGFC

organism-sequence


PR:Q8CI19-1 platelet-derived growth factor C isoform 1 (mouse)
mPDGFC/iso:1

organism-modification


PR:000036571 platelet-derived growth factor C isoform 1 cleaved 1 (mouse)
mPDGFC/iso:1/Clv:1
Yes
organism-gene


PR:Q9EQX6 platelet-derived growth factor C (rat)
rPDGFC

organism-gene


PR:Q9I946 platelet-derived growth factor C (chicken)
chick-PDGFC

organism-gene


PR:Q9NRA1 platelet-derived growth factor C (human)
hPDGFC

organism-sequence


PR:Q9NRA1-1 platelet-derived growth factor C isoform 1 (human)
hPDGFC/iso:1

organism-modification


PR:000036572 platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form (human)
hPDGFC/iso:1/Sumo1+
Yes
organism-modification


PR:000063004 platelet-derived growth factor C isoform 1, signal peptide removed form (human)
hPDGFC/iso:1/SigPep-

organism-modification


PR:000036570 platelet-derived growth factor C isoform 1 cleaved 1 (human)
hPDGFC/iso:1/Clv:1
Yes
organism-sequence


PR:Q9NRA1-2 platelet-derived growth factor C isoform h2 (human)
hPDGFC/iso:h2

organism-sequence


PR:Q9NRA1-3 platelet-derived growth factor C isoform h3 (human)
hPDGFC/iso:h3

organism-sequence


PR:Q9NRA1-4 platelet-derived growth factor C isoform h4 (human)
hPDGFC/iso:h4

sequence


PR:000000754 platelet-derived growth factor C isoform 1
PDGFC/iso:1

organism-sequence


PR:Q8CI19-1 platelet-derived growth factor C isoform 1 (mouse)
mPDGFC/iso:1

organism-modification


PR:000036571 platelet-derived growth factor C isoform 1 cleaved 1 (mouse)
mPDGFC/iso:1/Clv:1
Yes
organism-sequence


PR:Q9NRA1-1 platelet-derived growth factor C isoform 1 (human)
hPDGFC/iso:1

organism-modification


PR:000036572 platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form (human)
hPDGFC/iso:1/Sumo1+
Yes
organism-modification


PR:000063004 platelet-derived growth factor C isoform 1, signal peptide removed form (human)
hPDGFC/iso:1/SigPep-

organism-modification


PR:000036570 platelet-derived growth factor C isoform 1 cleaved 1 (human)
hPDGFC/iso:1/Clv:1
Yes
modification


PR:000000934 platelet-derived growth factor C isoform 1 sumoylated form
PDGFC/iso:1/SumoLys+

modification


PR:000000983 platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form
PDGFC/iso:1/Sumo1+

organism-modification


PR:000036572 platelet-derived growth factor C isoform 1 mono-SUMO1-ylated form (human)
hPDGFC/iso:1/Sumo1+
Yes
modification


PR:000021917 platelet-derived growth factor C isoform 1, signal peptide removed form
PDGFC/iso:1/SigPep-

modification


PR:000000982 platelet-derived growth factor C isoform 1 cleaved 1
PDGFC/iso:1/Clv:1

organism-modification


PR:000036570 platelet-derived growth factor C isoform 1 cleaved 1 (human)
hPDGFC/iso:1/Clv:1
Yes
organism-modification


PR:000036571 platelet-derived growth factor C isoform 1 cleaved 1 (mouse)
mPDGFC/iso:1/Clv:1
Yes
organism-modification


PR:000063004 platelet-derived growth factor C isoform 1, signal peptide removed form (human)
hPDGFC/iso:1/SigPep-

organism-modification


PR:000036570 platelet-derived growth factor C isoform 1 cleaved 1 (human)
hPDGFC/iso:1/Clv:1
Yes
modification


PR:000018298 platelet-derived growth factor C proteolytic cleavage product
PDGFC/ClvPrd

modification


PR:000000982 platelet-derived growth factor C isoform 1 cleaved 1
PDGFC/iso:1/Clv:1

organism-modification


PR:000036570 platelet-derived growth factor C isoform 1 cleaved 1 (human)
hPDGFC/iso:1/Clv:1
Yes
organism-modification


PR:000036571 platelet-derived growth factor C isoform 1 cleaved 1 (mouse)
mPDGFC/iso:1/Clv:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036570 hPDGFC/iso:1/Clv:1
UniProtKB:Q9NRA1-1, 226-345		 enablesGO:0005102 signaling receptor binding PMID:10806482; PMID:11297552
GO:0008083 growth factor activity PMID:10806482; PMID:11297552
located_inGO:0005615 extracellular space PMID:15911618
PR:000036571 mPDGFC/iso:1/Clv:1
UniProtKB:Q8CI19-1, 226-345		 acts_upstream_of_or_withinGO:0042060 wound healing PMID:11297552
located_inGO:0005615 extracellular space PMID:15372073
PR:000036572 hPDGFC/iso:1/Sumo1+
UniProtKB:Q9NRA1-1, MOD:01149~PR:000050074		 located_inGO:0005634 nucleus PMID:16443219