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Protein Ontology report - potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
PR:000000706 - http://purl.obolibrary.org/obo/PR_000000706
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000706   
  PRO namepotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 
  Synonyms
PRO-Short-label: EXACT:HCN2
Gene-based: RELATED:BCNG2 | Hac1
Other: EXACT:BCNG-2 | brain cyclic nucleotide-gated channel 2 | HAC-1 | hyperpolarization-activated cation channel 1
  Definition"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000676 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 1                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500961;IUPHARobj:401
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000706 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
HCN2

organism-gene


PR:O88703 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse)
mHCN2

organism-sequence


PR:O88703-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)
mHCN2/iso:1
Yes
organism-modification


PR:000036574 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
mHCN2/iso:1/NGlyco:1
Yes
organism-modification


PR:000046119 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 phosphorylated 1 (mouse)
mHCN2/Phos:1

organism-modification


PR:000084040 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 deaminated 1 (mouse)
mHCN2/Deam:1

organism-gene


PR:Q9JKA9 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (rat)
rHCN2

organism-gene


PR:Q9UL51 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (human)
hHCN2
Yes
sequence


PR:000000756 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1
HCN2/iso:1

organism-sequence


PR:O88703-1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)
mHCN2/iso:1
Yes
organism-modification


PR:000036574 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
mHCN2/iso:1/NGlyco:1
Yes
modification


PR:000000936 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form
HCN2/iso:1/GlycoRes+

modification


PR:000000985 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1
HCN2/iso:1/NGlyco:1

organism-modification


PR:000036574 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)
mHCN2/iso:1/NGlyco:1
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006812 monoatomic cation transportPR:Q9UL51 hHCN2 PMID:10228147
GO:0006936 muscle contractionPR:Q9UL51 hHCN2 PMID:10228147
GO:0007267 cell-cell signalingPR:Q9UL51 hHCN2 PMID:9630217

Molecular Function GO Term
Protein Forms & Complexes
Evidence
contributes_to GO:0005222 intracellularly cAMP-activated cation channel activityPR:O88703-1 mHCN2/iso:1 PMID:11459060
GO:0005261 monoatomic cation channel activityPR:Q9UL51 hHCN2 PMID:10228147

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0009986 cell surfacePR:000036574 mHCN2/iso:1/NGlyco:1 PMID:12928435
PR:O88703-1 mHCN2/iso:1 PMID:12034718; PMID:15564593
GO:0032991 protein-containing complexPR:O88703-1 mHCN2/iso:1 PMID:12034718