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Protein Ontology report - potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
PR:000000706 - http://purl.obolibrary.org/obo/PR_000000706
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000706   
  PRO namepotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 
  Synonyms
PRO-Short-label: EXACT:HCN2
Gene-based: RELATED:BCNG2 | Hac1
Other: EXACT:BCNG-2 | brain cyclic nucleotide-gated channel 2 | HAC-1 | hyperpolarization-activated cation channel 1
  Definition"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000676 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 1                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500961;IUPHARobj:401
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000706

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

HCN2


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel protein that is a translation product of the human HCN2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O88703

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse)

mHCN2


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of mouse." [OMA:O88703, PRO:DNx]


organism-sequence



PR:O88703-1

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)

mHCN2/iso:1


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036574

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)

mHCN2/iso:1/NGlyco:1


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]

Yes

organism-modification



PR:000046119

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 phosphorylated 1 (mouse)

mHCN2/Phos:1


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse) that has been phosphorylated at Ser-641. UniProtKB:O88703, Ser-641, MOD:00046." [iPTMnet:O88703, PMID:21347269]


organism-modification



PR:000084040

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 deaminated 1 (mouse)

mHCN2/Deam:1


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (mouse) that has been deaminated on the residue at the position equivalent to Gln-694 of the amino acid sequence represented by UniProtKB:O88703. UniProtKB:O88703, Gln-694, MOD:00685." [IEDB_epitope:2136599, PRO:DNx]


organism-gene



PR:Q9JKA9

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (rat)

rHCN2


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of rat." [OMA:Q9JKA9, PRO:DNx]


organism-gene



PR:Q9UL51

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (human)

hHCN2


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UL51]

Yes

sequence



PR:000000756

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1

HCN2/iso:1


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O88703-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O88703-1

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 (mouse)

mHCN2/iso:1


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036574

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)

mHCN2/iso:1/NGlyco:1


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]

Yes

modification



PR:000000936

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form

HCN2/iso:1/GlycoRes+


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 that includes at least one glycosylated residue." [PRO:CNA]


modification



PR:000000985

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1

HCN2/iso:1/NGlyco:1


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 glycosylated form with N-glycosylation at the N-linked glycosylation consensus sequence (Nx[ST]) in the extracellular domain between S5 and S6 transmembrane segments. Example: UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435]


organism-modification



PR:000036574

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 (mouse)

mHCN2/iso:1/NGlyco:1


"A potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform 1 N-glycosylated 1 in mouse. UniProtKB:O88703-1, Asn-380, MOD:00160." [PMID:12928435, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036574 mHCN2/iso:1/NGlyco:1
UniProtKB:O88703-1, Asn-380, MOD:00160
located_inGO:0009986 cell surface PMID:12928435
PR:O88703-1 mHCN2/iso:1 enablescontributes_to GO:0005222 intracellularly cAMP-activated cation channel activity PMID:11459060
located_inGO:0009986 cell surface PMID:12034718; PMID:15564593
GO:0032991 protein-containing complex PMID:12034718
PR:Q9UL51 hHCN2 acts_upstream_of_or_withinGO:0006812 monoatomic cation transport PMID:10228147
GO:0006936 muscle contraction PMID:10228147
GO:0007267 cell-cell signaling PMID:9630217
enablesGO:0005261 monoatomic cation channel activity PMID:10228147