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Protein Ontology report - shaker-related voltage-gated potassium channel alpha subunit
PR:000000709 - http://purl.obolibrary.org/obo/PR_000000709
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000709   
  PRO nameshaker-related voltage-gated potassium channel alpha subunit 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_shaker_sub-a
Other: RELATED:Kv1
  Definition"A voltage-gated potassium channel alpha subunit that is a member of the subfamily A of voltage-gated potassium channels. The N terminus is rich in basic residues and this region is critical for the N-type inactivation. Shaker-related voltage-gated potassium channels (Kv1 channels) play an important role in modulating electrical excitability of axons." [PMID:11506885] 
  PRO Categoryfamily 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene6                                                  Organism-Gene 18                                        
         Sequence9                                                  Organism-Sequence 26                                        
         Modification7                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000709 shaker-related voltage-gated potassium channel alpha subunit
fam:Kchan_shaker_sub-a

gene


PR:000000809 voltage-gated potassium channel subunit KCNA10
KCNA10

organism-gene


PR:B2RQA1 potassium voltage-gated channel subfamily A member 10 (mouse)
mKCNA10

organism-gene


PR:Q16322 potassium voltage-gated channel subfamily A member 10 (human)
hKCNA10

organism-sequence


PR:Q16322-1 potassium voltage-gated channel subfamily A member 10 isoform 1 (human)
hKCNA10/iso:1
Yes
organism-gene


PR:Q7T199 potassium voltage-gated channel subfamily A member 10 (chicken)
chick-KCNA10

sequence


PR:000000971 voltage-gated potassium channel subunit KCNA10 isoform 1
KCNA10/iso:1

organism-sequence


PR:Q16322-1 potassium voltage-gated channel subfamily A member 10 isoform 1 (human)
hKCNA10/iso:1
Yes
gene


PR:000000810 voltage-gated potassium channel subunit KCNA2
KCNA2

organism-gene


PR:P16389 potassium voltage-gated channel subfamily A member 2 (human)
hKCNA2

organism-sequence


PR:P16389-1 potassium voltage-gated channel subfamily A member 2 isoform 1 (human)
hKCNA2/iso:1
Yes
organism-modification


PR:000036584 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)
hKCNA2/iso:1/Phos:1
Yes
organism-modification


PR:000036587 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)
hKCNA2/iso:1/Phos:2
Yes
organism-sequence


PR:P16389-2 potassium voltage-gated channel subfamily A member 2 isoform h2 (human)
hKCNA2/iso:h2

organism-gene


PR:P63141 potassium voltage-gated channel subfamily A member 2 (mouse)
mKCNA2

organism-sequence


PR:P63141-1 potassium voltage-gated channel subfamily A member 2 isoform 1 (mouse)
mKCNA2/iso:1

organism-modification


PR:000036585 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)
mKCNA2/iso:1/Phos:2
Yes
organism-gene


PR:P63142 potassium voltage-gated channel subfamily A member 2 (rat)
rKCNA2

organism-sequence


PR:P63142-1 potassium voltage-gated channel subfamily A member 2 isoform 1 (rat)
rKCNA2/iso:1
Yes
organism-modification


PR:000036586 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)
rKCNA2/iso:1/Phos:2
Yes
organism-gene


PR:Q8I4B0 potassium voltage-gated channel protein shk-1 (worm)
KCNA2 (worm)

organism-sequence


PR:Q8I4B0-1 potassium voltage-gated channel protein shk-1 isoform c (worm)
KCNA2/iso:c (worm)

organism-sequence


PR:Q8I4B0-2 potassium voltage-gated channel protein shk-1 isoform b (worm)
KCNA2/iso:b (worm)

organism-sequence


PR:Q8I4B0-3 potassium voltage-gated channel protein shk-1 isoform d (worm)
KCNA2/iso:d (worm)

organism-sequence


PR:Q8I4B0-4 potassium voltage-gated channel protein shk-1 isoform a (worm)
KCNA2/iso:a (worm)

organism-sequence


PR:Q8I4B0-5 potassium voltage-gated channel protein shk-1 isoform e (worm)
KCNA2/iso:e (worm)

organism-sequence


PR:Q8I4B0-6 potassium voltage-gated channel protein shk-1 isoform f (worm)
KCNA2/iso:f (worm)

organism-sequence


PR:Q8I4B0-7 potassium voltage-gated channel protein shk-1 isoform g (worm)
KCNA2/iso:g (worm)

sequence


PR:000000972 voltage-gated potassium channel subunit KCNA2 isoform 1
KCNA2/iso:1

organism-sequence


PR:P16389-1 potassium voltage-gated channel subfamily A member 2 isoform 1 (human)
hKCNA2/iso:1
Yes
organism-modification


PR:000036584 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)
hKCNA2/iso:1/Phos:1
Yes
organism-modification


PR:000036587 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)
hKCNA2/iso:1/Phos:2
Yes
organism-sequence


PR:P63141-1 potassium voltage-gated channel subfamily A member 2 isoform 1 (mouse)
mKCNA2/iso:1

organism-modification


PR:000036585 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)
mKCNA2/iso:1/Phos:2
Yes
organism-sequence


PR:P63142-1 potassium voltage-gated channel subfamily A member 2 isoform 1 (rat)
rKCNA2/iso:1
Yes
organism-modification


PR:000036586 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)
rKCNA2/iso:1/Phos:2
Yes
modification


PR:000000991 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form
KCNA2/iso:1/PhosRes+

modification


PR:000001000 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1
KCNA2/iso:1/Phos:1

organism-modification


PR:000036584 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)
hKCNA2/iso:1/Phos:1
Yes
modification


PR:000001001 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2
KCNA2/iso:1/Phos:2

organism-modification


PR:000036585 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)
mKCNA2/iso:1/Phos:2
Yes
organism-modification


PR:000036586 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)
rKCNA2/iso:1/Phos:2
Yes
organism-modification


PR:000036587 voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)
hKCNA2/iso:1/Phos:2
Yes
gene


PR:000000811 voltage-gated potassium channel subunit KCNA3
KCNA3

organism-gene


PR:P15384 potassium voltage-gated channel subfamily A member 3 (rat)
rKCNA3

organism-gene


PR:P16390 potassium voltage-gated channel subfamily A member 3 (mouse)
mKCNA3

organism-gene


PR:P22001 potassium voltage-gated channel subfamily A member 3 (human)
hKCNA3

organism-sequence


PR:P22001-1 potassium voltage-gated channel subfamily A member 3 isoform 1 (human)
hKCNA3/iso:1
Yes
organism-modification


PR:000036639 voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1 (human)
hKCNA3/iso:1/Phos:1
Yes
organism-modification


PR:000044708 voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form (human)
hKCNA3/iso:1/UnMod
Yes
organism-sequence


PR:P22001-4 potassium voltage-gated channel subfamily A member 3 isoform h2 (human)
hKCNA3/iso:h2

organism-sequence


PR:P22001-5 potassium voltage-gated channel subfamily A member 3 isoform h3 (human)
hKCNA3/iso:h3

organism-modification


PR:000065955 potassium voltage-gated channel subfamily A member 3 deaminated 1 (human)
hKCNA3/Deam:1

sequence


PR:000000973 voltage-gated potassium channel subunit KCNA3 isoform 1
KCNA3/iso:1

organism-sequence


PR:P22001-1 potassium voltage-gated channel subfamily A member 3 isoform 1 (human)
hKCNA3/iso:1
Yes
organism-modification


PR:000036639 voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1 (human)
hKCNA3/iso:1/Phos:1
Yes
organism-modification


PR:000044708 voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form (human)
hKCNA3/iso:1/UnMod
Yes
modification


PR:000002682 voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form
KCNA3/iso:1/UnMod

organism-modification


PR:000044708 voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form (human)
hKCNA3/iso:1/UnMod
Yes
modification


PR:000003223 voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated form
KCNA3/iso:1/PhosRes+

modification


PR:000003224 voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1
KCNA3/iso:1/Phos:1

organism-modification


PR:000036639 voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1 (human)
hKCNA3/iso:1/Phos:1
Yes
gene


PR:000000812 voltage-gated potassium channel subunit KCNA5
KCNA5

organism-gene


PR:P19024 potassium voltage-gated channel subfamily A member 5 (rat)
rKCNA5

organism-gene


PR:P22460 potassium voltage-gated channel subfamily A member 5 (human)
hKCNA5

organism-sequence


PR:P22460-1 potassium voltage-gated channel subfamily A member 5 isoform 1 (human)
hKCNA5/iso:1
Yes
organism-sequence


PR:000036568 potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)
hKCNA5/iso:1/var:E375*
Yes
organism-sequence


PR:P22460-2 potassium voltage-gated channel subfamily A member 5 isoform h2 (human)
hKCNA5/iso:h2

organism-gene


PR:Q61762 potassium voltage-gated channel subfamily A member 5 (mouse)
mKCNA5

organism-sequence


PR:Q61762-1 potassium voltage-gated channel subfamily A member 5 isoform 1 (mouse)
mKCNA5/iso:1
Yes
organism-sequence


PR:Q61762-2 potassium voltage-gated channel subfamily A member 5 isoform 2 (mouse)
mKCNA5/iso:2
Yes
organism-sequence


PR:Q61762-3 potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)
mKCNA5/iso:3
Yes
sequence


PR:000000974 voltage-gated potassium channel subunit KCNA5 isoform 1
KCNA5/iso:1

organism-sequence


PR:P22460-1 potassium voltage-gated channel subfamily A member 5 isoform 1 (human)
hKCNA5/iso:1
Yes
organism-sequence


PR:000036568 potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)
hKCNA5/iso:1/var:E375*
Yes
organism-sequence


PR:Q61762-1 potassium voltage-gated channel subfamily A member 5 isoform 1 (mouse)
mKCNA5/iso:1
Yes
sequence


PR:000000975 voltage-gated potassium channel subunit KCNA5 isoform 2
KCNA5/iso:2

organism-sequence


PR:Q61762-2 potassium voltage-gated channel subfamily A member 5 isoform 2 (mouse)
mKCNA5/iso:2
Yes
modification


PR:000002684 voltage-gated potassium channel subunit KCNA5 isoform 2 unmodified form
KCNA5/iso:2/UnMod
Yes
sequence


PR:000000976 voltage-gated potassium channel subunit KCNA5 isoform 3
KCNA5/iso:3

organism-sequence


PR:Q61762-3 potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)
mKCNA5/iso:3
Yes
gene


PR:000000813 voltage-gated potassium channel subunit KCNA6
KCNA6

organism-gene


PR:P17658 potassium voltage-gated channel subfamily A member 6 (human)
hKCNA6

organism-sequence


PR:P17658-1 potassium voltage-gated channel subfamily A member 6 isoform 1 (human)
hKCNA6/iso:1

organism-gene


PR:P17659 potassium voltage-gated channel subfamily A member 6 (rat)
rKCNA6

organism-gene


PR:Q61923 potassium voltage-gated channel subfamily A member 6 (mouse)
mKCNA6

organism-sequence


PR:Q61923-1 potassium voltage-gated channel subfamily A member 6 isoform 1 (mouse)
mKCNA6/iso:1

sequence


PR:000000978 voltage-gated potassium channel subunit KCNA6 isoform 1
KCNA6/iso:1

organism-sequence


PR:P17658-1 potassium voltage-gated channel subfamily A member 6 isoform 1 (human)
hKCNA6/iso:1

organism-sequence


PR:Q61923-1 potassium voltage-gated channel subfamily A member 6 isoform 1 (mouse)
mKCNA6/iso:1

gene


PR:000000814 voltage-gated potassium channel subunit KCNA7
KCNA7

organism-gene


PR:Q17ST2 potassium voltage-gated channel subfamily A member 7 (mouse)
mKCNA7

organism-sequence


PR:Q17ST2-1 potassium voltage-gated channel subfamily A member 7 isoform 1 (mouse)
mKCNA7/iso:1
Yes
organism-sequence


PR:Q17ST2-2 potassium voltage-gated channel subfamily A member 7 isoform 2 (mouse)
mKCNA7/iso:2
Yes
organism-gene


PR:Q96RP8 potassium voltage-gated channel subfamily A member 7 (human)
hKCNA7

organism-sequence


PR:Q96RP8-1 potassium voltage-gated channel subfamily A member 7 isoform 1 (human)
hKCNA7/iso:1

organism-modification


PR:000069415 potassium voltage-gated channel subfamily A member 7 phosphorylated 1 (human)
hKCNA7/Phos:1

sequence


PR:000000979 voltage-gated potassium channel subunit KCNA7 isoform 1
KCNA7/iso:1

organism-sequence


PR:Q17ST2-1 potassium voltage-gated channel subfamily A member 7 isoform 1 (mouse)
mKCNA7/iso:1
Yes
sequence


PR:000000980 voltage-gated potassium channel subunit KCNA7 isoform 2
KCNA7/iso:2

organism-sequence


PR:Q17ST2-2 potassium voltage-gated channel subfamily A member 7 isoform 2 (mouse)
mKCNA7/iso:2
Yes
organism-sequence


PR:Q96RP8-1 potassium voltage-gated channel subfamily A member 7 isoform 1 (human)
hKCNA7/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000002684 KCNA5/iso:2/UnMod located_inGO:0005886 plasma membrane MGI_ref:63618; PMID:8226976
PR:000036568 hKCNA5/iso:1/var:E375*
UniProtKB:P22460-1, 1-374		 enablesNOT|contributes_to GO:0005251 delayed rectifier potassium channel activity PMID:16772329
PR:000036584 hKCNA2/iso:1/Phos:1
UniProtKB:P16389-1, Tyr-132, MOD:00048		 enablesNOT GO:0005251 delayed rectifier potassium channel activity PMID:15215309
located_inGO:0005768 endosome PMID:15215309
PR:000036585 mKCNA2/iso:1/Phos:2
UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046		 located_inGO:0008076 voltage-gated potassium channel complex PMID:18056633
GO:0009986 cell surface PMID:18056633
PR:000036586 rKCNA2/iso:1/Phos:2
UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046		 located_inGO:0008076 voltage-gated potassium channel complex PMID:18056633
GO:0009986 cell surface PMID:18056633
PR:000036587 hKCNA2/iso:1/Phos:2
UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046		 located_inGO:0008076 voltage-gated potassium channel complex PMID:18056633
GO:0009986 cell surface PMID:18056633
PR:000036639 hKCNA3/iso:1/Phos:1 enablesdecreased GO:0015271 outward rectifier potassium channel activity relative to PR:000002682 KCNA3/iso:1/UnMod PMID:9989602
PR:000044708 hKCNA3/iso:1/UnMod enablesGO:0015271 outward rectifier potassium channel activity PMID:9989602
PR:P16389-1 hKCNA2/iso:1 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:1715584
located_inGO:0008076 voltage-gated potassium channel complex PMID:2251283
GO:0009986 cell surface PMID:15215309
PR:P22001-1 hKCNA3/iso:1 enablesGO:0005251 delayed rectifier potassium channel activity PMID:1986382
located_inGO:0005743 mitochondrial inner membrane PMID:15632141
GO:0005886 plasma membrane PMID:15632141
PR:P22460-1 hKCNA5/iso:1 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:1986382
PR:P63142-1 rKCNA2/iso:1 enablesGO:0005515 protein binding with PR:P78352 DLG4 PMID:17959782
PR:Q16322-1 hKCNA10/iso:1 enablescontributes_to GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity PMID:10836990; PMID:9177773
contributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10836990
located_inGO:0008076 voltage-gated potassium channel complex PMID:12060596
PR:Q17ST2-1 mKCNA7/iso:1 enablesGO:0005249 voltage-gated potassium channel activity PMID:16801386
located_inGO:0008076 voltage-gated potassium channel complex PMID:16801386
PR:Q17ST2-2 mKCNA7/iso:2 enablesGO:0005249 voltage-gated potassium channel activity PMID:16801386
located_inGO:0008076 voltage-gated potassium channel complex PMID:16801386
PR:Q61762-1 mKCNA5/iso:1 acts_upstream_of_or_withinGO:0006813 potassium ion transport MGI_ref:63618; PMID:8226976
enablesGO:0005249 voltage-gated potassium channel activity MGI_ref:63618; PMID:8226976
located_inGO:0005886 plasma membrane MGI_ref:63618; PMID:8226976
PR:Q61762-2 mKCNA5/iso:2 acts_upstream_of_or_withinGO:0006813 potassium ion transport MGI_ref:63618; PMID:8226976
enablesGO:0005249 voltage-gated potassium channel activity MGI_ref:63618; PMID:8226976
located_inGO:0005886 plasma membrane MGI_ref:63618; PMID:8226976
PR:Q61762-3 mKCNA5/iso:3 acts_upstream_of_or_withinGO:0043267 negative regulation of potassium ion transport MGI_ref:63618; PMID:8226976
enablesGO:0019870 potassium channel inhibitor activity MGI_ref:63618; PMID:8226976