back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - shaker-related voltage-gated potassium channel alpha subunit
PR:000000709 - http://purl.obolibrary.org/obo/PR_000000709
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000709   
  PRO nameshaker-related voltage-gated potassium channel alpha subunit 
  Synonyms
PRO-Short-label: EXACT:fam:Kchan_shaker_sub-a
Other: RELATED:Kv1
  Definition"A voltage-gated potassium channel alpha subunit that is a member of the subfamily A of voltage-gated potassium channels. The N terminus is rich in basic residues and this region is critical for the N-type inactivation. Shaker-related voltage-gated potassium channels (Kv1 channels) play an important role in modulating electrical excitability of axons." [PMID:11506885
  PRO Categoryfamily 
  ParentPR:000000685 voltage-gated potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene6                                                  Organism-Gene 18                                        
         Sequence9                                                  Organism-Sequence 26                                        
         Modification7                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000709

shaker-related voltage-gated potassium channel alpha subunit

fam:Kchan_shaker_sub-a


"A voltage-gated potassium channel alpha subunit that is a member of the subfamily A of voltage-gated potassium channels. The N terminus is rich in basic residues and this region is critical for the N-type inactivation. Shaker-related voltage-gated potassium channels (Kv1 channels) play an important role in modulating electrical excitability of axons." [PMID:11506885]


gene



PR:000000809

voltage-gated potassium channel subunit KCNA10

KCNA10


"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA10 gene or a 1:1 ortholog thereof. It is a subunit of the Kv1.8 channel is a delayed rectifier channel that may be involved in regulating the tone of renal vascular smooth muscle and may also participate in the cardiac action potential. It is regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. It can coassemble with other Kv1 subunits." [PMID:10836990]


organism-gene



PR:B2RQA1

potassium voltage-gated channel subfamily A member 10 (mouse)

mKCNA10


"A voltage-gated potassium channel subunit KCNA10 that is encoded in the genome of mouse." [OMA:B2RQA1, PRO:DNx]


organism-gene



PR:Q16322

potassium voltage-gated channel subfamily A member 10 (human)

hKCNA10


"A voltage-gated potassium channel subunit KCNA10 that is encoded in the genome of human." []


organism-sequence



PR:Q16322-1

potassium voltage-gated channel subfamily A member 10 isoform 1 (human)

hKCNA10/iso:1


"A voltage-gated potassium channel subunit KCNA10 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-gene



PR:Q7T199

potassium voltage-gated channel subfamily A member 10 (chicken)

chick-KCNA10


"A voltage-gated potassium channel subunit KCNA10 that is encoded in the genome of chicken." [PRO:DNx, UniProtKB:Q7T199]


sequence



PR:000000971

voltage-gated potassium channel subunit KCNA10 isoform 1

KCNA10/iso:1


"A voltage-gated potassium channel subunit KCNA10 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16322-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q16322-1

potassium voltage-gated channel subfamily A member 10 isoform 1 (human)

hKCNA10/iso:1


"A voltage-gated potassium channel subunit KCNA10 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

gene



PR:000000810

voltage-gated potassium channel subunit KCNA2

KCNA2


"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA2 gene or a 1:1 ortholog thereof. The Kv1.2 channel is involved in maintaining membrane potential, modulating electrical excitability in neurons and muscle. It can coassemble with other Kv1 subunits." [PMID:16382104]


organism-gene



PR:P16389

potassium voltage-gated channel subfamily A member 2 (human)

hKCNA2


"A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of human." []


organism-sequence



PR:P16389-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (human)

hKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036584

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)

hKCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 in human. UniProtKB:P16389-1, Tyr-132, MOD:00048." [PMID:15215309, PRO:CNA]

Yes

organism-modification



PR:000036587

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)

hKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in human. UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA]

Yes

organism-sequence



PR:P16389-2

potassium voltage-gated channel subfamily A member 2 isoform h2 (human)

hKCNA2/iso:h2


"A potassium voltage-gated channel subfamily A member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16389-2." [PRO:DNx, UniProtKB:P16389]


organism-gene



PR:P63141

potassium voltage-gated channel subfamily A member 2 (mouse)

mKCNA2


"A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of mouse." [OMA:P63141, PRO:DNx]


organism-sequence



PR:P63141-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (mouse)

mKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036585

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)

mKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in mouse. UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-gene



PR:P63142

potassium voltage-gated channel subfamily A member 2 (rat)

rKCNA2


"A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of rat." [OMA:P63142, PRO:DNx]


organism-sequence



PR:P63142-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (rat)

rKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-modification



PR:000036586

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)

rKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in rat. UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-gene



PR:Q8I4B0

potassium voltage-gated channel protein shk-1 (worm)

KCNA2 (worm)


"A voltage-gated potassium channel subunit KCNA2 that is encoded in the genome of worm." [OMA:Q8I4B0, PRO:DNx]


organism-sequence



PR:Q8I4B0-1

potassium voltage-gated channel protein shk-1 isoform c (worm)

KCNA2/iso:c (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-1." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-2

potassium voltage-gated channel protein shk-1 isoform b (worm)

KCNA2/iso:b (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-2." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-3

potassium voltage-gated channel protein shk-1 isoform d (worm)

KCNA2/iso:d (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-3." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-4

potassium voltage-gated channel protein shk-1 isoform a (worm)

KCNA2/iso:a (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-4." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-5

potassium voltage-gated channel protein shk-1 isoform e (worm)

KCNA2/iso:e (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-5." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-6

potassium voltage-gated channel protein shk-1 isoform f (worm)

KCNA2/iso:f (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-6." [PRO:DNx, UniProtKB:Q8I4B0]


organism-sequence



PR:Q8I4B0-7

potassium voltage-gated channel protein shk-1 isoform g (worm)

KCNA2/iso:g (worm)


"A potassium voltage-gated channel protein shk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8I4B0-7." [PRO:DNx, UniProtKB:Q8I4B0]


sequence



PR:000000972

voltage-gated potassium channel subunit KCNA2 isoform 1

KCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P16389-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P16389-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (human)

hKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036584

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)

hKCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 in human. UniProtKB:P16389-1, Tyr-132, MOD:00048." [PMID:15215309, PRO:CNA]

Yes

organism-modification



PR:000036587

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)

hKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in human. UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA]

Yes

organism-sequence



PR:P63141-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (mouse)

mKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036585

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)

mKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in mouse. UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P63142-1

potassium voltage-gated channel subfamily A member 2 isoform 1 (rat)

rKCNA2/iso:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that is encoded in the genome of rat." [PRO:CNA]

Yes

organism-modification



PR:000036586

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)

rKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in rat. UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000991

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form

KCNA2/iso:1/PhosRes+


"A voltage-gated potassium channel subunit KCNA2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000001000

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1

KCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the REDEGYIK sequence located adjacent to the tetramerization domain. Phosphorylation at this site promotes endocytosis and suppresses the channel activity. Example: UniProtKB:P16389-1, Tyr-132, MOD:00048." [PRO:CNA]


organism-modification



PR:000036584

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 (human)

hKCNA2/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 1 in human. UniProtKB:P16389-1, Tyr-132, MOD:00048." [PMID:15215309, PRO:CNA]

Yes

modification



PR:000001001

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2

KCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated form in which the phosphorylation occurs at the pair of Ser residues within the SSPD motif at the C terminus. Phosphorylation at this site promotes cell surface localization. Example: UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633]


organism-modification



PR:000036585

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (mouse)

mKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in mouse. UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036586

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (rat)

rKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in rat. UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036587

voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 (human)

hKCNA2/iso:1/Phos:2


"A voltage-gated potassium channel subunit KCNA2 isoform 1 phosphorylated 2 in human. UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046." [PMID:18056633, PRO:CNA]

Yes

gene



PR:000000811

voltage-gated potassium channel subunit KCNA3

KCNA3


"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA3 gene or a 1:1 ortholog thereof. The Kv1.3 channel is involved in maintaining membrane potential and calcium signaling in lymphocytes and oligodendrocytes. It can coassemble with other Kv1 subunits." [PRO:CNA]


organism-gene



PR:P15384

potassium voltage-gated channel subfamily A member 3 (rat)

rKCNA3


"A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of rat." [OMA:P15384, PRO:DNx]


organism-gene



PR:P16390

potassium voltage-gated channel subfamily A member 3 (mouse)

mKCNA3


"A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of mouse." [OMA:P16390, PRO:DNx]


organism-gene



PR:P22001

potassium voltage-gated channel subfamily A member 3 (human)

hKCNA3


"A voltage-gated potassium channel subunit KCNA3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P22001]


organism-sequence



PR:P22001-1

potassium voltage-gated channel subfamily A member 3 isoform 1 (human)

hKCNA3/iso:1


"A voltage-gated potassium channel subunit KCNA3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036639

voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1 (human)

hKCNA3/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1 in human." [PMID:9989602, PRO:CL]

Yes

organism-modification



PR:000044708

voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form (human)

hKCNA3/iso:1/UnMod


"A voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form in human." [PRO:DNx]

Yes

organism-sequence



PR:P22001-4

potassium voltage-gated channel subfamily A member 3 isoform h2 (human)

hKCNA3/iso:h2


"A potassium voltage-gated channel subfamily A member 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22001-4." [PRO:DNx, UniProtKB:P22001]


organism-sequence



PR:P22001-5

potassium voltage-gated channel subfamily A member 3 isoform h3 (human)

hKCNA3/iso:h3


"A potassium voltage-gated channel subfamily A member 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22001-5." [PRO:DNx, UniProtKB:P22001]


organism-modification



PR:000065955

potassium voltage-gated channel subfamily A member 3 deaminated 1 (human)

hKCNA3/Deam:1


"A potassium voltage-gated channel subfamily A member 3 (human) that has been deaminated on the residue at the position equivalent to Asn-109 of the amino acid sequence represented by UniProtKB:P22001. UniProtKB:P22001, Asn-109, MOD:00684." [IEDB_epitope:1752498, PRO:DNx]


sequence



PR:000000973

voltage-gated potassium channel subunit KCNA3 isoform 1

KCNA3/iso:1


"A voltage-gated potassium channel subunit KCNA3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22001-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P22001-1

potassium voltage-gated channel subfamily A member 3 isoform 1 (human)

hKCNA3/iso:1


"A voltage-gated potassium channel subunit KCNA3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036639

voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1 (human)

hKCNA3/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1 in human." [PMID:9989602, PRO:CL]

Yes

organism-modification



PR:000044708

voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form (human)

hKCNA3/iso:1/UnMod


"A voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form in human." [PRO:DNx]

Yes

modification



PR:000002682

voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form

KCNA3/iso:1/UnMod


"A voltage-gated potassium channel subunit KCNA3 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


organism-modification



PR:000044708

voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form (human)

hKCNA3/iso:1/UnMod


"A voltage-gated potassium channel subunit KCNA3 isoform 1 unmodified form in human." [PRO:DNx]

Yes

modification



PR:000003223

voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated form

KCNA3/iso:1/PhosRes+


"A voltage-gated potassium channel subunit KCNA3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000003224

voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1

KCNA3/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated form in which the phosphorylation occurs as a result of the interaction of HIV gp160 with CD4. Probably phosphorylated by PKC." [PMID:9989602, PRO:CL]


organism-modification



PR:000036639

voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1 (human)

hKCNA3/iso:1/Phos:1


"A voltage-gated potassium channel subunit KCNA3 isoform 1 phosphorylated 1 in human." [PMID:9989602, PRO:CL]

Yes

gene



PR:000000812

voltage-gated potassium channel subunit KCNA5

KCNA5


"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA5 gene or a 1:1 ortholog thereof. The voltage-gated potassium channel Kv1.5 mediates the ultrarapid-activating potassium current (IKur) in heart, and also plays a critical role in the regulation of arterial tone." [PMID:10575199, PMID:16772329, PMID:18344374]


organism-gene



PR:P19024

potassium voltage-gated channel subfamily A member 5 (rat)

rKCNA5


"A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of rat." [OMA:P19024, PRO:DNx]


organism-gene



PR:P22460

potassium voltage-gated channel subfamily A member 5 (human)

hKCNA5


"A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of human." []


organism-sequence



PR:P22460-1

potassium voltage-gated channel subfamily A member 5 isoform 1 (human)

hKCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:000036568

potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)

hKCNA5/iso:1/var:E375*


"A potassium voltage-gated channel subfamily A member 5 isoform 1 (human) that has a C-terminal truncation and thus lacks the S4-S6 voltage sensor, pore region and C terminus, but preserves the N terminus and S1-S3 transmembrane domains that secure tetrameric subunit assembly. UniProtKB:P22460-1, 1-374." [PMID:16772329, PRO:CNA]

Yes

organism-sequence



PR:P22460-2

potassium voltage-gated channel subfamily A member 5 isoform h2 (human)

hKCNA5/iso:h2


"A potassium voltage-gated channel subfamily A member 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22460-2." [PRO:DNx, UniProtKB:P22460]


organism-gene



PR:Q61762

potassium voltage-gated channel subfamily A member 5 (mouse)

mKCNA5


"A voltage-gated potassium channel subunit KCNA5 that is encoded in the genome of mouse." [OMA:Q61762, PRO:DNx]


organism-sequence



PR:Q61762-1

potassium voltage-gated channel subfamily A member 5 isoform 1 (mouse)

mKCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q61762-2

potassium voltage-gated channel subfamily A member 5 isoform 2 (mouse)

mKCNA5/iso:2


"A voltage-gated potassium channel subunit KCNA5 isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]

Yes

organism-sequence



PR:Q61762-3

potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)

mKCNA5/iso:3


"A voltage-gated potassium channel subunit KCNA5 isoform 3 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]

Yes

sequence



PR:000000974

voltage-gated potassium channel subunit KCNA5 isoform 1

KCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P22460-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P22460-1

potassium voltage-gated channel subfamily A member 5 isoform 1 (human)

hKCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:000036568

potassium voltage-gated channel subfamily A member 5 isoform 1 sequence variant E375* (human)

hKCNA5/iso:1/var:E375*


"A potassium voltage-gated channel subfamily A member 5 isoform 1 (human) that has a C-terminal truncation and thus lacks the S4-S6 voltage sensor, pore region and C terminus, but preserves the N terminus and S1-S3 transmembrane domains that secure tetrameric subunit assembly. UniProtKB:P22460-1, 1-374." [PMID:16772329, PRO:CNA]

Yes

organism-sequence



PR:Q61762-1

potassium voltage-gated channel subfamily A member 5 isoform 1 (mouse)

mKCNA5/iso:1


"A voltage-gated potassium channel subunit KCNA5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

sequence



PR:000000975

voltage-gated potassium channel subunit KCNA5 isoform 2

KCNA5/iso:2


"A voltage-gated potassium channel subunit KCNA5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61762-2 or a 1:1 ortholog thereof." [PMID:11524461, PMID:8226976, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q61762-2

potassium voltage-gated channel subfamily A member 5 isoform 2 (mouse)

mKCNA5/iso:2


"A voltage-gated potassium channel subunit KCNA5 isoform 2 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]

Yes

modification



PR:000002684

voltage-gated potassium channel subunit KCNA5 isoform 2 unmodified form

KCNA5/iso:2/UnMod


"A voltage-gated potassium channel subunit KCNA5 isoform 2 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]

Yes

sequence



PR:000000976

voltage-gated potassium channel subunit KCNA5 isoform 3

KCNA5/iso:3


"A voltage-gated potassium channel subunit KCNA5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q61762-3 or a 1:1 ortholog thereof." [PMID:8226976, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q61762-3

potassium voltage-gated channel subfamily A member 5 isoform 3 (mouse)

mKCNA5/iso:3


"A voltage-gated potassium channel subunit KCNA5 isoform 3 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q61762]

Yes

gene



PR:000000813

voltage-gated potassium channel subunit KCNA6

KCNA6


"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA6 gene or a 1:1 ortholog thereof. The Kv1.6 channel is Regulator of membrane potential in neurons. The N terminus contains an N terminus inactivation prevention domain. It can coassemble with other Kv1 subunits." [PRO:CNA]


organism-gene



PR:P17658

potassium voltage-gated channel subfamily A member 6 (human)

hKCNA6


"A voltage-gated potassium channel subunit KCNA6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P17658]


organism-sequence



PR:P17658-1

potassium voltage-gated channel subfamily A member 6 isoform 1 (human)

hKCNA6/iso:1


"A voltage-gated potassium channel subunit KCNA6 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-gene



PR:P17659

potassium voltage-gated channel subfamily A member 6 (rat)

rKCNA6


"A voltage-gated potassium channel subunit KCNA6 that is encoded in the genome of rat." [OMA:P17659, PRO:DNx]


organism-gene



PR:Q61923

potassium voltage-gated channel subfamily A member 6 (mouse)

mKCNA6


"A voltage-gated potassium channel subunit KCNA6 that is encoded in the genome of mouse." [OMA:Q61923, PRO:DNx]


organism-sequence



PR:Q61923-1

potassium voltage-gated channel subfamily A member 6 isoform 1 (mouse)

mKCNA6/iso:1


"A voltage-gated potassium channel subunit KCNA6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000978

voltage-gated potassium channel subunit KCNA6 isoform 1

KCNA6/iso:1


"A voltage-gated potassium channel subunit KCNA6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P17658-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P17658-1

potassium voltage-gated channel subfamily A member 6 isoform 1 (human)

hKCNA6/iso:1


"A voltage-gated potassium channel subunit KCNA6 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q61923-1

potassium voltage-gated channel subfamily A member 6 isoform 1 (mouse)

mKCNA6/iso:1


"A voltage-gated potassium channel subunit KCNA6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


gene



PR:000000814

voltage-gated potassium channel subunit KCNA7

KCNA7


"A shaker-related voltage-gated potassium channel alpha subunit that is a translation product of the human KCNA7 gene or a 1:1 ortholog thereof. The Kv1.7 channel has properties similar to the ultrarapidly activating IKur current in the heart. It can coassemble with other Kv1 subunits." [PRO:CNA]


organism-gene



PR:Q17ST2

potassium voltage-gated channel subfamily A member 7 (mouse)

mKCNA7


"A voltage-gated potassium channel subunit KCNA7 that is encoded in the genome of mouse." [OMA:Q17ST2, PRO:DNx]


organism-sequence



PR:Q17ST2-1

potassium voltage-gated channel subfamily A member 7 isoform 1 (mouse)

mKCNA7/iso:1


"A voltage-gated potassium channel subunit KCNA7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q17ST2-2

potassium voltage-gated channel subfamily A member 7 isoform 2 (mouse)

mKCNA7/iso:2


"A voltage-gated potassium channel subunit KCNA7 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:Q96RP8

potassium voltage-gated channel subfamily A member 7 (human)

hKCNA7


"A voltage-gated potassium channel subunit KCNA7 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96RP8]


organism-sequence



PR:Q96RP8-1

potassium voltage-gated channel subfamily A member 7 isoform 1 (human)

hKCNA7/iso:1


"A voltage-gated potassium channel subunit KCNA7 isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000069415

potassium voltage-gated channel subfamily A member 7 phosphorylated 1 (human)

hKCNA7/Phos:1


"A potassium voltage-gated channel subfamily A member 7 (human) that has been phosphorylated on the residue at the position equivalent to Ser-308 of the amino acid sequence represented by UniProtKB:Q96RP8. UniProtKB:Q96RP8, Ser-308, MOD:00046." [IEDB_epitope:2148639, PRO:DNx]


sequence



PR:000000979

voltage-gated potassium channel subunit KCNA7 isoform 1

KCNA7/iso:1


"A voltage-gated potassium channel subunit KCNA7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17ST2-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q17ST2-1

potassium voltage-gated channel subfamily A member 7 isoform 1 (mouse)

mKCNA7/iso:1


"A voltage-gated potassium channel subunit KCNA7 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

sequence



PR:000000980

voltage-gated potassium channel subunit KCNA7 isoform 2

KCNA7/iso:2


"A voltage-gated potassium channel subunit KCNA7 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q17ST2-2 or a 1:1 ortholog thereof. This form contributes to channels that are slow-inactivating and redox-insensitive." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q17ST2-2

potassium voltage-gated channel subfamily A member 7 isoform 2 (mouse)

mKCNA7/iso:2


"A voltage-gated potassium channel subunit KCNA7 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q96RP8-1

potassium voltage-gated channel subfamily A member 7 isoform 1 (human)

hKCNA7/iso:1


"A voltage-gated potassium channel subunit KCNA7 isoform 2 that is encoded in the genome of human." [PRO:CNA]


Back to top
Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000002684 KCNA5/iso:2/UnMod located_inGO:0005886 plasma membrane MGI_ref:63618; PMID:8226976
PR:000036568 hKCNA5/iso:1/var:E375*
UniProtKB:P22460-1, 1-374
enablesNOT|contributes_to GO:0005251 delayed rectifier potassium channel activity PMID:16772329
PR:000036584 hKCNA2/iso:1/Phos:1
UniProtKB:P16389-1, Tyr-132, MOD:00048
enablesNOT GO:0005251 delayed rectifier potassium channel activity PMID:15215309
located_inGO:0005768 endosome PMID:15215309
PR:000036585 mKCNA2/iso:1/Phos:2
UniProtKB:P63141-1, Ser-440/Ser-441, MOD:00046
located_inGO:0008076 voltage-gated potassium channel complex PMID:18056633
GO:0009986 cell surface PMID:18056633
PR:000036586 rKCNA2/iso:1/Phos:2
UniProtKB:P63142-1, Ser-440/Ser-441, MOD:00046
located_inGO:0008076 voltage-gated potassium channel complex PMID:18056633
GO:0009986 cell surface PMID:18056633
PR:000036587 hKCNA2/iso:1/Phos:2
UniProtKB:P16389-1, Ser-440/Ser-441, MOD:00046
located_inGO:0008076 voltage-gated potassium channel complex PMID:18056633
GO:0009986 cell surface PMID:18056633
PR:000036639 hKCNA3/iso:1/Phos:1 enablesdecreased GO:0015271 outward rectifier potassium channel activity relative to PR:000002682 KCNA3/iso:1/UnMod PMID:9989602
PR:000044708 hKCNA3/iso:1/UnMod enablesGO:0015271 outward rectifier potassium channel activity PMID:9989602
PR:P16389-1 hKCNA2/iso:1 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:1715584
located_inGO:0008076 voltage-gated potassium channel complex PMID:2251283
GO:0009986 cell surface PMID:15215309
PR:P22001-1 hKCNA3/iso:1 enablesGO:0005251 delayed rectifier potassium channel activity PMID:1986382
located_inGO:0005743 mitochondrial inner membrane PMID:15632141
GO:0005886 plasma membrane PMID:15632141
PR:P22460-1 hKCNA5/iso:1 enablescontributes_to GO:0005251 delayed rectifier potassium channel activity PMID:1986382
PR:P63142-1 rKCNA2/iso:1 enablesGO:0005515 protein binding with PR:P78352 DLG4 PMID:17959782
PR:Q16322-1 hKCNA10/iso:1 enablescontributes_to GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity PMID:10836990; PMID:9177773
contributes_to GO:0005251 delayed rectifier potassium channel activity PMID:10836990
located_inGO:0008076 voltage-gated potassium channel complex PMID:12060596
PR:Q17ST2-1 mKCNA7/iso:1 enablesGO:0005249 voltage-gated potassium channel activity PMID:16801386
located_inGO:0008076 voltage-gated potassium channel complex PMID:16801386
PR:Q17ST2-2 mKCNA7/iso:2 enablesGO:0005249 voltage-gated potassium channel activity PMID:16801386
located_inGO:0008076 voltage-gated potassium channel complex PMID:16801386
PR:Q61762-1 mKCNA5/iso:1 acts_upstream_of_or_withinGO:0006813 potassium ion transport MGI_ref:63618; PMID:8226976
enablesGO:0005249 voltage-gated potassium channel activity MGI_ref:63618; PMID:8226976
located_inGO:0005886 plasma membrane MGI_ref:63618; PMID:8226976
PR:Q61762-2 mKCNA5/iso:2 acts_upstream_of_or_withinGO:0006813 potassium ion transport MGI_ref:63618; PMID:8226976
enablesGO:0005249 voltage-gated potassium channel activity MGI_ref:63618; PMID:8226976
located_inGO:0005886 plasma membrane MGI_ref:63618; PMID:8226976
PR:Q61762-3 mKCNA5/iso:3 acts_upstream_of_or_withinGO:0043267 negative regulation of potassium ion transport MGI_ref:63618; PMID:8226976
enablesGO:0019870 potassium channel inhibitor activity MGI_ref:63618; PMID:8226976