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Protein Ontology report - small conductance calcium-activated potassium channel protein 3
PR:000000714 - http://purl.obolibrary.org/obo/PR_000000714
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000714   
  PRO namesmall conductance calcium-activated potassium channel protein 3 
  Synonyms
PRO-Short-label: EXACT:KCNN3
Gene-based: RELATED:K3
Other: EXACT:KCa2.3 | SK3 | SKCa 3 | SKCa3
  Definition"A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN3 gene or a 1:1 ortholog thereof. The KCNN3 gene contains two arrays of CAG trinucleotide repeats, which are highly polymorphic. The SK3 channels are thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000668 calcium-activated calmodulin-binding potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:383
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000714 small conductance calcium-activated potassium channel protein 3
KCNN3

organism-gene


PR:P58391 small conductance calcium-activated potassium channel protein 3 (mouse)
mKCNN3

organism-gene


PR:P70605 small conductance calcium-activated potassium channel protein 3 (rat)
rKCNN3

organism-gene


PR:Q9UGI6 small conductance calcium-activated potassium channel protein 3 (human)
hKCNN3

organism-sequence


PR:000029956 small conductance calcium-activated potassium channel protein 3 sequence variant 1 (human)
hKCNN3/var:1
Yes
organism-sequence


PR:Q9UGI6-1 small conductance calcium-activated potassium channel protein 3 isoform 1 (human)
hKCNN3/iso:1
Yes
organism-sequence


PR:Q9UGI6-2 small conductance calcium-activated potassium channel protein 3 isoform h2 (human)
hKCNN3/iso:h2

organism-sequence


PR:Q9UGI6-3 small conductance calcium-activated potassium channel protein 3 isoform h3 (human)
hKCNN3/iso:h3

sequence


PR:000000773 small conductance calcium-activated potassium channel protein 3 isoform 1
KCNN3/iso:1

organism-sequence


PR:Q9UGI6-1 small conductance calcium-activated potassium channel protein 3 isoform 1 (human)
hKCNN3/iso:1
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029956 hKCNN3/var:1
However, it conserves the two glutamine rich domains		 enablesNOT GO:0015269 calcium-activated potassium channel activity PMID:11395478
located_inGO:0005634 nucleus PMID:11395478
PR:Q9UGI6-1 hKCNN3/iso:1 located_inGO:0009986 cell surface PMID:11395478