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Protein Ontology report - small conductance calcium-activated potassium channel protein 3
PR:000000714 - http://purl.obolibrary.org/obo/PR_000000714
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000714   
  PRO namesmall conductance calcium-activated potassium channel protein 3 
  Synonyms
PRO-Short-label: EXACT:KCNN3
Gene-based: RELATED:K3
Other: EXACT:KCa2.3 | SK3 | SKCa 3 | SKCa3
  Definition"A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN3 gene or a 1:1 ortholog thereof. The KCNN3 gene contains two arrays of CAG trinucleotide repeats, which are highly polymorphic. The SK3 channels are thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000668 calcium-activated calmodulin-binding potassium channel alpha subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:383
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000714

small conductance calcium-activated potassium channel protein 3

KCNN3


"A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN3 gene or a 1:1 ortholog thereof. The KCNN3 gene contains two arrays of CAG trinucleotide repeats, which are highly polymorphic. The SK3 channels are thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization." [PRO:CNA]


organism-gene



PR:P58391

small conductance calcium-activated potassium channel protein 3 (mouse)

mKCNN3


"A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of mouse." [OMA:P58391, PRO:CNA]


organism-gene



PR:P70605

small conductance calcium-activated potassium channel protein 3 (rat)

rKCNN3


"A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of rat." [OMA:P70605, PRO:DNx]


organism-gene



PR:Q9UGI6

small conductance calcium-activated potassium channel protein 3 (human)

hKCNN3


"A small conductance calcium-activated potassium channel protein 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UGI6]


organism-sequence



PR:000029956

small conductance calcium-activated potassium channel protein 3 sequence variant 1 (human)

hKCNN3/var:1


"A small conductance calcium-activated potassium channel protein 3 (human) that has a C-terminal truncation due to frameshift and premature stop, such that the sequence is equivalent to UniProtKB:Q9UGI6-1, 1-283, plus the residues TML. The truncated protein lacks the transmembrane and the calmodulin binding domains. However, it conserves the two glutamine rich domains." [PMID:11395478, PRO:DAN]

Yes

organism-sequence



PR:Q9UGI6-1

small conductance calcium-activated potassium channel protein 3 isoform 1 (human)

hKCNN3/iso:1


"A small conductance calcium-activated potassium channel protein 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q9UGI6-2

small conductance calcium-activated potassium channel protein 3 isoform h2 (human)

hKCNN3/iso:h2


"A small conductance calcium-activated potassium channel protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGI6-2." [PRO:DNx, UniProtKB:Q9UGI6]


organism-sequence



PR:Q9UGI6-3

small conductance calcium-activated potassium channel protein 3 isoform h3 (human)

hKCNN3/iso:h3


"A small conductance calcium-activated potassium channel protein 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGI6-3." [PRO:DNx, UniProtKB:Q9UGI6]


sequence



PR:000000773

small conductance calcium-activated potassium channel protein 3 isoform 1

KCNN3/iso:1


"A small conductance calcium-activated potassium channel protein 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UGI6-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9UGI6-1

small conductance calcium-activated potassium channel protein 3 isoform 1 (human)

hKCNN3/iso:1


"A small conductance calcium-activated potassium channel protein 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000029956 hKCNN3/var:1
However, it conserves the two glutamine rich domains
enablesNOT GO:0015269 calcium-activated potassium channel activity PMID:11395478
located_inGO:0005634 nucleus PMID:11395478
PR:Q9UGI6-1 hKCNN3/iso:1 located_inGO:0009986 cell surface PMID:11395478